Estimating the toxicities of organic chemicals to bioluminescent bacteria and activated sludge
Toxicity assays based on bioluminescent bacteria have several advantages including a quick response and an easily measured signal. The Shk1 assay is a procedure for wastewater toxicity testing based on the bioluminescent bacterium Shk1. Using the Shk1 assay, the toxicity of 98 organic chemicals were...
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| Veröffentlicht in: | Water research (Oxford) 2002-10, Vol.36 (17), p.4406-4414 |
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| creator | Ren, Shijin Frymier, Paul D |
| description | Toxicity assays based on bioluminescent bacteria have several advantages including a quick response and an easily measured signal. The Shk1 assay is a procedure for wastewater toxicity testing based on the bioluminescent bacterium Shk1. Using the Shk1 assay, the toxicity of 98 organic chemicals were measured and EC
50 values were obtained. Quantitative structure–activity relationship (QSAR) models based on the logarithm of the octanol–water partition coefficient (log(
K
ow)) were developed for individual groups of organic chemicals with different functional groups. The correlation coefficients for different groups of organic compounds varied between 0.69 and 0.99. An overall QSAR model without discriminating the functional groups, which can be used for a quick estimate of the toxicities of organic chemicals, was also developed and model predictions were compared to experimental data. The model accuracy was found to be one order of magnitude from the observed values. |
| doi_str_mv | 10.1016/S0043-1354(02)00153-7 |
| format | Article |
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50 values were obtained. Quantitative structure–activity relationship (QSAR) models based on the logarithm of the octanol–water partition coefficient (log(
K
ow)) were developed for individual groups of organic chemicals with different functional groups. The correlation coefficients for different groups of organic compounds varied between 0.69 and 0.99. An overall QSAR model without discriminating the functional groups, which can be used for a quick estimate of the toxicities of organic chemicals, was also developed and model predictions were compared to experimental data. The model accuracy was found to be one order of magnitude from the observed values.</description><identifier>ISSN: 0043-1354</identifier><identifier>EISSN: 1879-2448</identifier><identifier>DOI: 10.1016/S0043-1354(02)00153-7</identifier><identifier>PMID: 12420944</identifier><identifier>CODEN: WATRAG</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Activated sludge ; Applied sciences ; Bacteria - drug effects ; Biological and medical sciences ; Biological treatment of waters ; Bioluminescent bacteria ; Biotechnology ; Environment and pollution ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; General purification processes ; Industrial applications and implications. Economical aspects ; Kow ; Luminescent Measurements ; Organic Chemicals - toxicity ; Pollution ; QSAR ; Quantitative Structure-Activity Relationship ; Sewage - microbiology ; Shk1 ; Toxicity ; Toxicity Tests ; Wastewaters ; Water - chemistry ; Water Pollutants - toxicity ; Water treatment and pollution</subject><ispartof>Water research (Oxford), 2002-10, Vol.36 (17), p.4406-4414</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8c3bc971de07fc82de40d331f22e06720c4fd13b4e01e094dd7dc8c0afe267f93</citedby><cites>FETCH-LOGICAL-c422t-8c3bc971de07fc82de40d331f22e06720c4fd13b4e01e094dd7dc8c0afe267f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0043135402001537$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13930862$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12420944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Shijin</creatorcontrib><creatorcontrib>Frymier, Paul D</creatorcontrib><title>Estimating the toxicities of organic chemicals to bioluminescent bacteria and activated sludge</title><title>Water research (Oxford)</title><addtitle>Water Res</addtitle><description>Toxicity assays based on bioluminescent bacteria have several advantages including a quick response and an easily measured signal. The Shk1 assay is a procedure for wastewater toxicity testing based on the bioluminescent bacterium Shk1. Using the Shk1 assay, the toxicity of 98 organic chemicals were measured and EC
50 values were obtained. Quantitative structure–activity relationship (QSAR) models based on the logarithm of the octanol–water partition coefficient (log(
K
ow)) were developed for individual groups of organic chemicals with different functional groups. The correlation coefficients for different groups of organic compounds varied between 0.69 and 0.99. An overall QSAR model without discriminating the functional groups, which can be used for a quick estimate of the toxicities of organic chemicals, was also developed and model predictions were compared to experimental data. The model accuracy was found to be one order of magnitude from the observed values.</description><subject>Activated sludge</subject><subject>Applied sciences</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biological treatment of waters</subject><subject>Bioluminescent bacteria</subject><subject>Biotechnology</subject><subject>Environment and pollution</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General purification processes</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Kow</subject><subject>Luminescent Measurements</subject><subject>Organic Chemicals - toxicity</subject><subject>Pollution</subject><subject>QSAR</subject><subject>Quantitative Structure-Activity Relationship</subject><subject>Sewage - microbiology</subject><subject>Shk1</subject><subject>Toxicity</subject><subject>Toxicity Tests</subject><subject>Wastewaters</subject><subject>Water - chemistry</subject><subject>Water Pollutants - toxicity</subject><subject>Water treatment and pollution</subject><issn>0043-1354</issn><issn>1879-2448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOHDEQRS1EFAaSTyDyBkQWTcqPme5eIYTIQ0JikWQby10uD0b9ANuNyN_Hw4zCkpUt-VzXrcPYsYBzAWL15SeAVpVQS30G8jOAWKqq3mML0dRtJbVu9tniP3LADlO6BwApVfueHQipJbRaL9if65TDYHMY1zzfEc_Tc8CQAyU-eT7FtR0DcryjIaDtU3nnXZj6eQgjJaQx885iphgst6Pj5R6ebCbHUz-7NX1g73yJ0cfdecR-f73-dfW9urn99uPq8qZCLWWuGlQdtrVwBLXHRjrS4JQSXkqCVS0BtXdCdZpAUCnuXO2wQbCe5Kr2rTpip9t_H-L0OFPKZgilXt_bkaY5GdG2GsqoAi63IMYppUjePMSyf_xrBJiNWPMi1mysGZDmRaypS-7TbsDcDeReUzuTBTjZATYVUz7aEUN65VSroFltClxsOSo6ngJFkzDQiORCJMzGTeGNKv8A9YaWIQ</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Ren, Shijin</creator><creator>Frymier, Paul D</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7UA</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20021001</creationdate><title>Estimating the toxicities of organic chemicals to bioluminescent bacteria and activated sludge</title><author>Ren, Shijin ; Frymier, Paul D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-8c3bc971de07fc82de40d331f22e06720c4fd13b4e01e094dd7dc8c0afe267f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Activated sludge</topic><topic>Applied sciences</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biological treatment of waters</topic><topic>Bioluminescent bacteria</topic><topic>Biotechnology</topic><topic>Environment and pollution</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. 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The Shk1 assay is a procedure for wastewater toxicity testing based on the bioluminescent bacterium Shk1. Using the Shk1 assay, the toxicity of 98 organic chemicals were measured and EC
50 values were obtained. Quantitative structure–activity relationship (QSAR) models based on the logarithm of the octanol–water partition coefficient (log(
K
ow)) were developed for individual groups of organic chemicals with different functional groups. The correlation coefficients for different groups of organic compounds varied between 0.69 and 0.99. An overall QSAR model without discriminating the functional groups, which can be used for a quick estimate of the toxicities of organic chemicals, was also developed and model predictions were compared to experimental data. The model accuracy was found to be one order of magnitude from the observed values.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12420944</pmid><doi>10.1016/S0043-1354(02)00153-7</doi><tpages>9</tpages></addata></record> |
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| subjects | Activated sludge Applied sciences Bacteria - drug effects Biological and medical sciences Biological treatment of waters Bioluminescent bacteria Biotechnology Environment and pollution Exact sciences and technology Fundamental and applied biological sciences. Psychology General purification processes Industrial applications and implications. Economical aspects Kow Luminescent Measurements Organic Chemicals - toxicity Pollution QSAR Quantitative Structure-Activity Relationship Sewage - microbiology Shk1 Toxicity Toxicity Tests Wastewaters Water - chemistry Water Pollutants - toxicity Water treatment and pollution |
| title | Estimating the toxicities of organic chemicals to bioluminescent bacteria and activated sludge |
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