Immune Reconstitution Inflammatory Syndrome Associated With HIV and Leprosy
BACKGROUND Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction to an opportunistic infection that occurs in human immunodeficiency virus (HIV)–positive patients with profound immunosuppression during the reconstitution of the immune system in the initial months of...
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| Veröffentlicht in: | Archives of dermatology (1960) 2004-08, Vol.140 (8), p.997-1000 |
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| container_title | Archives of dermatology (1960) |
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| creator | Couppié, Pierre Abel, Sylvie Voinchet, Hélène Roussel, Morgane Hélénon, Raymond Huerre, Michel Sainte-Marie, Dominique Cabié, André |
| description | BACKGROUND Immune reconstitution inflammatory syndrome (IRIS) is an unusual inflammatory reaction to an opportunistic infection that occurs in human immunodeficiency virus (HIV)–positive patients with profound immunosuppression during the reconstitution of the immune system in the initial months of highly active antiretroviral treatment. OBSERVATIONS We describe 3 cases of leprosy occurring in patients treated with a combination of 3 antiretroviral drugs who fulfilled the criteria for IRIS. A reactional state occurred in all 3 cases. Two of the 3 patients presented an unusual ulcerous progression of the lesions not generally observed in cases of leprosy. The outcome was favorable in all 3 cases. The frequency of IRIS associated with leprosy in French Guiana and Martinique is estimated at 3 cases per 1000 HIV-positive patients receiving highly active antiretroviral treatment. CONCLUSION Leprosy should be recognized as an IRIS-associated infection with possibility of atypical presentation.
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| doi_str_mv | 10.1001/archderm.140.8.997 |
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--></description><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS-Related Opportunistic Infections - pathology</subject><subject>Anti-HIV Agents - administration & dosage</subject><subject>Anti-HIV Agents - adverse effects</subject><subject>Autoimmune Diseases - chemically induced</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - pathology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - drug therapy</subject><subject>Human bacterial diseases</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Leprostatic Agents - administration & dosage</subject><subject>Leprosy</subject><subject>Leprosy - diagnosis</subject><subject>Leprosy - drug therapy</subject><subject>Leprosy - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Tropical bacterial diseases</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><issn>0003-987X</issn><issn>2168-6068</issn><issn>1538-3652</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0U1P2zAYB3Br2rR2ZR9gO0wREtzS-SXxyxEhWCsqTWLAdrOeOraaKnbATg799hjaUYmTD_49f9t_I_Sd4DnBmPyEaDaNjX5OKjyXc6XEBzQlNZMl4zX9iKYYY1YqKf5N0JeUtnmGSkk_o0lGhEkip-hm6f0YbHFrTR_S0A7j0PahWAbXgfcw9HFX_NmFJvbeFhcp9aaFwTbF33bYFIvlQwGhKVb2MfZpd4I-OeiS_XpYZ-j--uruclGufv9aXl6sSqhwPZQKEwBonKubSgnLiXOC1byuqVsLSanKwDmQ0DBHqSGSEgOUMc7rNXXcsBk63-fmU59Gmwbt22Rs10Gw_Zg0UarCRIkMT9_BbT_GkO-mcx6hleA8I7pHJr8hRev0Y2w9xJ0mWL_0rP_3rHPPWmr1mvzjkDyuvW2OI4diMzg7AEgGOhchmDYdHcdMiEpl923vwMPbbiWxyF_3DNsoj8A</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Couppié, Pierre</creator><creator>Abel, Sylvie</creator><creator>Voinchet, Hélène</creator><creator>Roussel, Morgane</creator><creator>Hélénon, Raymond</creator><creator>Huerre, Michel</creator><creator>Sainte-Marie, Dominique</creator><creator>Cabié, André</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>7T5</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20040801</creationdate><title>Immune Reconstitution Inflammatory Syndrome Associated With HIV and Leprosy</title><author>Couppié, Pierre ; 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OBSERVATIONS We describe 3 cases of leprosy occurring in patients treated with a combination of 3 antiretroviral drugs who fulfilled the criteria for IRIS. A reactional state occurred in all 3 cases. Two of the 3 patients presented an unusual ulcerous progression of the lesions not generally observed in cases of leprosy. The outcome was favorable in all 3 cases. The frequency of IRIS associated with leprosy in French Guiana and Martinique is estimated at 3 cases per 1000 HIV-positive patients receiving highly active antiretroviral treatment. CONCLUSION Leprosy should be recognized as an IRIS-associated infection with possibility of atypical presentation.
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| ispartof | Archives of dermatology (1960), 2004-08, Vol.140 (8), p.997-1000 |
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| subjects | AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - pathology Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Autoimmune Diseases - chemically induced Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy Autoimmune Diseases - pathology Bacterial diseases Biological and medical sciences Dermatology Diagnosis, Differential Female HIV Infections - diagnosis HIV Infections - drug therapy Human bacterial diseases Human immunodeficiency virus Humans Infectious diseases Leprostatic Agents - administration & dosage Leprosy Leprosy - diagnosis Leprosy - drug therapy Leprosy - pathology Male Medical sciences Middle Aged Tropical bacterial diseases Tuberculosis and atypical mycobacterial infections |
| title | Immune Reconstitution Inflammatory Syndrome Associated With HIV and Leprosy |
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