Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study
Leptin regulates bone cell differentiation and functions via direct and indirect actions in experimental settings. Epidemiologically, however, the impact of leptin on the regulation of bone metabolism remains unclear. While some studies have reported a positive relationship between leptin and bone m...
Gespeichert in:
| Veröffentlicht in: | Journal of bone and mineral metabolism 2019-01, Vol.37 (1), p.152-160 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 160 |
|---|---|
| container_issue | 1 |
| container_start_page | 152 |
| container_title | Journal of bone and mineral metabolism |
| container_volume | 37 |
| creator | Kouda, Katsuyasu Ohara, Kumiko Fujita, Yuki Nakamura, Harunobu Tachiki, Takahiro Iki, Masayuki |
| description | Leptin regulates bone cell differentiation and functions via direct and indirect actions in experimental settings. Epidemiologically, however, the impact of leptin on the regulation of bone metabolism remains unclear. While some studies have reported a positive relationship between leptin and bone mineral parameters, other studies found an inverse or no association. We analyzed data from a population-based follow-up survey of community-dwelling children in Hamamatsu, Japan, to investigate relationships between leptin levels and bone mineral parameters. Multiple regression analysis was performed. Multicollinearity was quantified using the variance infiltration factor (VIF). Among 408 children who participated in the baseline survey (at age 11.2 years), 254 (121 boys and 133 girls) completed the follow-up survey (at age 14.2 years). Leptin levels were strongly related to fat mass (
r
= 0.87 in boys,
r
= 0.80 in girls). Leptin levels at baseline were significantly (
P
|
| doi_str_mv | 10.1007/s00774-018-0909-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1993997254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1993656243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-1b010d2040a47d170f3e171ad11690cd6dc0472953075138f310220b1216761d3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EotvCA3BBlrhwMcw4TrzmhiooSJUqVeUcOfGkm8qxg510tW9fly0IIXHxHPzNP6P5GHuD8AEB9MdcHq0E4FaAASPgGdugqmpRN6Cesw0YVGKrtTlhpznfAaCuNb5kJ9JUptESN2x_Td4uYwx5N86Zd7TsiQLPlNaJe5qXMZRyTz5zGxzvYiA-jYGS9Xy2yU60UMq8ULnfxeiFvSXH-93oXaLwiVteiQPZxIfofdyLdeZ5Wd3hFXsxWJ_p9VM9Yz--frk5_yYury6-n3--FL1q5CKwAwQnQYFV2qGGoSLUaB1iY6B3jetBaWnqCnSN1XaoEKSEDiU2ukFXnbH3x9w5xZ8r5aWdxtyT9zZQXHOLppzCaFmrgr77B72Lawplu19UUzdSVYXCI9WnmHOioZ3TONl0aBHaRyvt0UpbrLSPVlooPW-fktduIven47eGAsgjkMtXuKX01-j_pj4ANhaWWA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993656243</pqid></control><display><type>article</type><title>Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kouda, Katsuyasu ; Ohara, Kumiko ; Fujita, Yuki ; Nakamura, Harunobu ; Tachiki, Takahiro ; Iki, Masayuki</creator><creatorcontrib>Kouda, Katsuyasu ; Ohara, Kumiko ; Fujita, Yuki ; Nakamura, Harunobu ; Tachiki, Takahiro ; Iki, Masayuki</creatorcontrib><description>Leptin regulates bone cell differentiation and functions via direct and indirect actions in experimental settings. Epidemiologically, however, the impact of leptin on the regulation of bone metabolism remains unclear. While some studies have reported a positive relationship between leptin and bone mineral parameters, other studies found an inverse or no association. We analyzed data from a population-based follow-up survey of community-dwelling children in Hamamatsu, Japan, to investigate relationships between leptin levels and bone mineral parameters. Multiple regression analysis was performed. Multicollinearity was quantified using the variance infiltration factor (VIF). Among 408 children who participated in the baseline survey (at age 11.2 years), 254 (121 boys and 133 girls) completed the follow-up survey (at age 14.2 years). Leptin levels were strongly related to fat mass (
r
= 0.87 in boys,
r
= 0.80 in girls). Leptin levels at baseline were significantly (
P
< 0.05) positively related to total body less head (TBLH) areal bone mineral density (aBMD) at follow-up in girls (standardized partial regression coefficient:
β
= 0.302, VIF = 2.246), after adjusting for body fat percentage (%). On the other hand, leptin levels were inversely related to TBLH aBMD in boys (
β
= − 0.395, VIF = 4.116), after adjusting for body fat mass (kg). Positive relationships between leptin levels and bone mineral parameters were observed with VIF values < 4.0, whereas inverse relationships were observed with VIF values ≥ 4.0. These findings suggest that positive relationships between leptin levels and bone mineral parameters are weak, or not always observed, due to statistical problems (i.e., multicollinearity) and other factors derived from adipose tissue.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-018-0909-0</identifier><identifier>PMID: 29396721</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adipose tissue ; Body fat ; Bone mass ; Bone mineral density ; Bone turnover ; Children ; Children & youth ; Data processing ; Epidemiology ; Leptin ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Multiple regression analysis ; Original Article ; Orthopedics</subject><ispartof>Journal of bone and mineral metabolism, 2019-01, Vol.37 (1), p.152-160</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2018</rights><rights>Journal of Bone and Mineral Metabolism is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-1b010d2040a47d170f3e171ad11690cd6dc0472953075138f310220b1216761d3</citedby><cites>FETCH-LOGICAL-c462t-1b010d2040a47d170f3e171ad11690cd6dc0472953075138f310220b1216761d3</cites><orcidid>0000-0002-0203-4824</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-018-0909-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-018-0909-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29396721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kouda, Katsuyasu</creatorcontrib><creatorcontrib>Ohara, Kumiko</creatorcontrib><creatorcontrib>Fujita, Yuki</creatorcontrib><creatorcontrib>Nakamura, Harunobu</creatorcontrib><creatorcontrib>Tachiki, Takahiro</creatorcontrib><creatorcontrib>Iki, Masayuki</creatorcontrib><title>Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>Leptin regulates bone cell differentiation and functions via direct and indirect actions in experimental settings. Epidemiologically, however, the impact of leptin on the regulation of bone metabolism remains unclear. While some studies have reported a positive relationship between leptin and bone mineral parameters, other studies found an inverse or no association. We analyzed data from a population-based follow-up survey of community-dwelling children in Hamamatsu, Japan, to investigate relationships between leptin levels and bone mineral parameters. Multiple regression analysis was performed. Multicollinearity was quantified using the variance infiltration factor (VIF). Among 408 children who participated in the baseline survey (at age 11.2 years), 254 (121 boys and 133 girls) completed the follow-up survey (at age 14.2 years). Leptin levels were strongly related to fat mass (
r
= 0.87 in boys,
r
= 0.80 in girls). Leptin levels at baseline were significantly (
P
< 0.05) positively related to total body less head (TBLH) areal bone mineral density (aBMD) at follow-up in girls (standardized partial regression coefficient:
β
= 0.302, VIF = 2.246), after adjusting for body fat percentage (%). On the other hand, leptin levels were inversely related to TBLH aBMD in boys (
β
= − 0.395, VIF = 4.116), after adjusting for body fat mass (kg). Positive relationships between leptin levels and bone mineral parameters were observed with VIF values < 4.0, whereas inverse relationships were observed with VIF values ≥ 4.0. These findings suggest that positive relationships between leptin levels and bone mineral parameters are weak, or not always observed, due to statistical problems (i.e., multicollinearity) and other factors derived from adipose tissue.</description><subject>Adipose tissue</subject><subject>Body fat</subject><subject>Bone mass</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Children</subject><subject>Children & youth</subject><subject>Data processing</subject><subject>Epidemiology</subject><subject>Leptin</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Multiple regression analysis</subject><subject>Original Article</subject><subject>Orthopedics</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kcFu1DAQhi0EotvCA3BBlrhwMcw4TrzmhiooSJUqVeUcOfGkm8qxg510tW9fly0IIXHxHPzNP6P5GHuD8AEB9MdcHq0E4FaAASPgGdugqmpRN6Cesw0YVGKrtTlhpznfAaCuNb5kJ9JUptESN2x_Td4uYwx5N86Zd7TsiQLPlNaJe5qXMZRyTz5zGxzvYiA-jYGS9Xy2yU60UMq8ULnfxeiFvSXH-93oXaLwiVteiQPZxIfofdyLdeZ5Wd3hFXsxWJ_p9VM9Yz--frk5_yYury6-n3--FL1q5CKwAwQnQYFV2qGGoSLUaB1iY6B3jetBaWnqCnSN1XaoEKSEDiU2ukFXnbH3x9w5xZ8r5aWdxtyT9zZQXHOLppzCaFmrgr77B72Lawplu19UUzdSVYXCI9WnmHOioZ3TONl0aBHaRyvt0UpbrLSPVlooPW-fktduIven47eGAsgjkMtXuKX01-j_pj4ANhaWWA</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Kouda, Katsuyasu</creator><creator>Ohara, Kumiko</creator><creator>Fujita, Yuki</creator><creator>Nakamura, Harunobu</creator><creator>Tachiki, Takahiro</creator><creator>Iki, Masayuki</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0203-4824</orcidid></search><sort><creationdate>20190101</creationdate><title>Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study</title><author>Kouda, Katsuyasu ; Ohara, Kumiko ; Fujita, Yuki ; Nakamura, Harunobu ; Tachiki, Takahiro ; Iki, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-1b010d2040a47d170f3e171ad11690cd6dc0472953075138f310220b1216761d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adipose tissue</topic><topic>Body fat</topic><topic>Bone mass</topic><topic>Bone mineral density</topic><topic>Bone turnover</topic><topic>Children</topic><topic>Children & youth</topic><topic>Data processing</topic><topic>Epidemiology</topic><topic>Leptin</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Multiple regression analysis</topic><topic>Original Article</topic><topic>Orthopedics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouda, Katsuyasu</creatorcontrib><creatorcontrib>Ohara, Kumiko</creatorcontrib><creatorcontrib>Fujita, Yuki</creatorcontrib><creatorcontrib>Nakamura, Harunobu</creatorcontrib><creatorcontrib>Tachiki, Takahiro</creatorcontrib><creatorcontrib>Iki, Masayuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouda, Katsuyasu</au><au>Ohara, Kumiko</au><au>Fujita, Yuki</au><au>Nakamura, Harunobu</au><au>Tachiki, Takahiro</au><au>Iki, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>37</volume><issue>1</issue><spage>152</spage><epage>160</epage><pages>152-160</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>Leptin regulates bone cell differentiation and functions via direct and indirect actions in experimental settings. Epidemiologically, however, the impact of leptin on the regulation of bone metabolism remains unclear. While some studies have reported a positive relationship between leptin and bone mineral parameters, other studies found an inverse or no association. We analyzed data from a population-based follow-up survey of community-dwelling children in Hamamatsu, Japan, to investigate relationships between leptin levels and bone mineral parameters. Multiple regression analysis was performed. Multicollinearity was quantified using the variance infiltration factor (VIF). Among 408 children who participated in the baseline survey (at age 11.2 years), 254 (121 boys and 133 girls) completed the follow-up survey (at age 14.2 years). Leptin levels were strongly related to fat mass (
r
= 0.87 in boys,
r
= 0.80 in girls). Leptin levels at baseline were significantly (
P
< 0.05) positively related to total body less head (TBLH) areal bone mineral density (aBMD) at follow-up in girls (standardized partial regression coefficient:
β
= 0.302, VIF = 2.246), after adjusting for body fat percentage (%). On the other hand, leptin levels were inversely related to TBLH aBMD in boys (
β
= − 0.395, VIF = 4.116), after adjusting for body fat mass (kg). Positive relationships between leptin levels and bone mineral parameters were observed with VIF values < 4.0, whereas inverse relationships were observed with VIF values ≥ 4.0. These findings suggest that positive relationships between leptin levels and bone mineral parameters are weak, or not always observed, due to statistical problems (i.e., multicollinearity) and other factors derived from adipose tissue.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>29396721</pmid><doi>10.1007/s00774-018-0909-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0203-4824</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-8779 |
| ispartof | Journal of bone and mineral metabolism, 2019-01, Vol.37 (1), p.152-160 |
| issn | 0914-8779 1435-5604 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1993997254 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Adipose tissue Body fat Bone mass Bone mineral density Bone turnover Children Children & youth Data processing Epidemiology Leptin Medicine Medicine & Public Health Metabolic Diseases Multiple regression analysis Original Article Orthopedics |
| title | Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T19%3A10%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationships%20between%20serum%20leptin%20levels%20and%20bone%20mineral%20parameters%20in%20school-aged%20children:%20a%203-year%20follow-up%20study&rft.jtitle=Journal%20of%20bone%20and%20mineral%20metabolism&rft.au=Kouda,%20Katsuyasu&rft.date=2019-01-01&rft.volume=37&rft.issue=1&rft.spage=152&rft.epage=160&rft.pages=152-160&rft.issn=0914-8779&rft.eissn=1435-5604&rft_id=info:doi/10.1007/s00774-018-0909-0&rft_dat=%3Cproquest_cross%3E1993656243%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1993656243&rft_id=info:pmid/29396721&rfr_iscdi=true |