Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton
Purpose The relationship between infective endocarditis (IE) and osteoarticular infections (OAIs) are not well known. We aimed to study the characteristics of patients with IE and OAIs, and the interactions between these two infections. Methods An observational study (1993–2014) which includes two c...
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| Veröffentlicht in: | Infection 2018-04, Vol.46 (2), p.245-251 |
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| creator | Murillo, Oscar Grau, Imma Gomez-Junyent, Joan Cabrera, Celina Ribera, Alba Tubau, Fe Peña, Carmen Ariza, Javier Pallares, Roman |
| description | Purpose
The relationship between infective endocarditis (IE) and osteoarticular infections (OAIs) are not well known. We aimed to study the characteristics of patients with IE and OAIs, and the interactions between these two infections.
Methods
An observational study (1993–2014) which includes two cohorts: (1) patients with IE (
n
= 607) and (2) patients with bacteremic OAIs (
n
= 458; septic arthritis of peripheral and axial skeleton, and vertebral and peripheral osteomyelitis). These two cohorts were prospectively collected, and we retrospectively reviewed the clinical and microbiological variables.
Results
There were 70 cases of IE with concomitant OAIs, representing 11.5% of IE cases and 15% of bacteremic OAI cases. Among cases with IE, the associated OAIs mainly involved the axial skeleton (
n
= 54, 77%): 43 were vertebral osteomyelitis (61%), mainly caused by “less virulent” bacteria (
viridans
and
bovis
streptococci, enterococci, and coagulase-negative staphylococci), and 15 were septic arthritis of the axial skeleton (21%), which were mainly caused by
Staphylococcus aureus
. OAIs with involvement of the axial skeleton were associated with IE (adjusted OR = 2.2; 95% CI 1.1–4.3) independently of age, sex, and microorganisms.
Conclusions
Among patients with IE, the associated OAIs mainly involve the axial skeleton. Transesophageal echocardiography should be carefully considered in patients presenting with these bacteremic OAIs. |
| doi_str_mv | 10.1007/s15010-018-1121-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1993995899</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1993995899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-cb2a81c64c99c1ae1aa1ac4f437dd8694688a0240fb648bf7bb5d0e17acaa7b53</originalsourceid><addsrcrecordid>eNp1kMtO5DAQRa0RaGh65gPYoEhs2ASq8rDjJUK8JCQ2zNqqOJXpQDrusd08_p50B0YIidWV7OPrqiPEAcIJAqjTgCUgpIBViphhqn-IGRa5TkGrfEfMIAdIK8zkntgP4QEASl2on2Iv07mWUuFMmIuhcZZ808UuJBSCsx1FbpLnLi6SJ_aRa0994kJkt3zlfuKGJgm8ip1NyMeF3x66NokLTuilG_nwyD1HN_wSuy31gX-_51z8uby4P79Ob--ubs7PblObqyymts6oQisLq7VFYiRCskVb5KppKqkLWVUEWQFtLYuqblVdlw0wKrJEqi7zuTieelfe_VtziGbZBct9TwO7dTCox5V1WY0xF0df0Ae39sM43ZaSpSxzNVI4Uda7EDy3ZuW7JflXg2A29s1k34z2zca-2TQfvjev6yU3_1986B6BbALCeDX8Zf_p629b3wDgDpEs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993656537</pqid></control><display><type>article</type><title>Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton</title><source>SpringerLink Journals - AutoHoldings</source><creator>Murillo, Oscar ; Grau, Imma ; Gomez-Junyent, Joan ; Cabrera, Celina ; Ribera, Alba ; Tubau, Fe ; Peña, Carmen ; Ariza, Javier ; Pallares, Roman</creator><creatorcontrib>Murillo, Oscar ; Grau, Imma ; Gomez-Junyent, Joan ; Cabrera, Celina ; Ribera, Alba ; Tubau, Fe ; Peña, Carmen ; Ariza, Javier ; Pallares, Roman</creatorcontrib><description>Purpose
The relationship between infective endocarditis (IE) and osteoarticular infections (OAIs) are not well known. We aimed to study the characteristics of patients with IE and OAIs, and the interactions between these two infections.
Methods
An observational study (1993–2014) which includes two cohorts: (1) patients with IE (
n
= 607) and (2) patients with bacteremic OAIs (
n
= 458; septic arthritis of peripheral and axial skeleton, and vertebral and peripheral osteomyelitis). These two cohorts were prospectively collected, and we retrospectively reviewed the clinical and microbiological variables.
Results
There were 70 cases of IE with concomitant OAIs, representing 11.5% of IE cases and 15% of bacteremic OAI cases. Among cases with IE, the associated OAIs mainly involved the axial skeleton (
n
= 54, 77%): 43 were vertebral osteomyelitis (61%), mainly caused by “less virulent” bacteria (
viridans
and
bovis
streptococci, enterococci, and coagulase-negative staphylococci), and 15 were septic arthritis of the axial skeleton (21%), which were mainly caused by
Staphylococcus aureus
. OAIs with involvement of the axial skeleton were associated with IE (adjusted OR = 2.2; 95% CI 1.1–4.3) independently of age, sex, and microorganisms.
Conclusions
Among patients with IE, the associated OAIs mainly involve the axial skeleton. Transesophageal echocardiography should be carefully considered in patients presenting with these bacteremic OAIs.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-018-1121-9</identifier><identifier>PMID: 29396671</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Arthritis ; Axial skeleton ; Bacteria ; Biocompatibility ; Bone diseases ; Coagulase ; Echocardiography ; Endocarditis ; Family Medicine ; General Practice ; Infectious Diseases ; Internal Medicine ; Medicine ; Medicine & Public Health ; Microorganisms ; Observational studies ; Original Paper ; Osteomyelitis ; Patients ; Sepsis ; Vertebrae ; Vertebral osteomyelitis</subject><ispartof>Infection, 2018-04, Vol.46 (2), p.245-251</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Infection is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-cb2a81c64c99c1ae1aa1ac4f437dd8694688a0240fb648bf7bb5d0e17acaa7b53</citedby><cites>FETCH-LOGICAL-c372t-cb2a81c64c99c1ae1aa1ac4f437dd8694688a0240fb648bf7bb5d0e17acaa7b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s15010-018-1121-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s15010-018-1121-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29396671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murillo, Oscar</creatorcontrib><creatorcontrib>Grau, Imma</creatorcontrib><creatorcontrib>Gomez-Junyent, Joan</creatorcontrib><creatorcontrib>Cabrera, Celina</creatorcontrib><creatorcontrib>Ribera, Alba</creatorcontrib><creatorcontrib>Tubau, Fe</creatorcontrib><creatorcontrib>Peña, Carmen</creatorcontrib><creatorcontrib>Ariza, Javier</creatorcontrib><creatorcontrib>Pallares, Roman</creatorcontrib><title>Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton</title><title>Infection</title><addtitle>Infection</addtitle><addtitle>Infection</addtitle><description>Purpose
The relationship between infective endocarditis (IE) and osteoarticular infections (OAIs) are not well known. We aimed to study the characteristics of patients with IE and OAIs, and the interactions between these two infections.
Methods
An observational study (1993–2014) which includes two cohorts: (1) patients with IE (
n
= 607) and (2) patients with bacteremic OAIs (
n
= 458; septic arthritis of peripheral and axial skeleton, and vertebral and peripheral osteomyelitis). These two cohorts were prospectively collected, and we retrospectively reviewed the clinical and microbiological variables.
Results
There were 70 cases of IE with concomitant OAIs, representing 11.5% of IE cases and 15% of bacteremic OAI cases. Among cases with IE, the associated OAIs mainly involved the axial skeleton (
n
= 54, 77%): 43 were vertebral osteomyelitis (61%), mainly caused by “less virulent” bacteria (
viridans
and
bovis
streptococci, enterococci, and coagulase-negative staphylococci), and 15 were septic arthritis of the axial skeleton (21%), which were mainly caused by
Staphylococcus aureus
. OAIs with involvement of the axial skeleton were associated with IE (adjusted OR = 2.2; 95% CI 1.1–4.3) independently of age, sex, and microorganisms.
Conclusions
Among patients with IE, the associated OAIs mainly involve the axial skeleton. Transesophageal echocardiography should be carefully considered in patients presenting with these bacteremic OAIs.</description><subject>Arthritis</subject><subject>Axial skeleton</subject><subject>Bacteria</subject><subject>Biocompatibility</subject><subject>Bone diseases</subject><subject>Coagulase</subject><subject>Echocardiography</subject><subject>Endocarditis</subject><subject>Family Medicine</subject><subject>General Practice</subject><subject>Infectious Diseases</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microorganisms</subject><subject>Observational studies</subject><subject>Original Paper</subject><subject>Osteomyelitis</subject><subject>Patients</subject><subject>Sepsis</subject><subject>Vertebrae</subject><subject>Vertebral osteomyelitis</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMtO5DAQRa0RaGh65gPYoEhs2ASq8rDjJUK8JCQ2zNqqOJXpQDrusd08_p50B0YIidWV7OPrqiPEAcIJAqjTgCUgpIBViphhqn-IGRa5TkGrfEfMIAdIK8zkntgP4QEASl2on2Iv07mWUuFMmIuhcZZ808UuJBSCsx1FbpLnLi6SJ_aRa0994kJkt3zlfuKGJgm8ip1NyMeF3x66NokLTuilG_nwyD1HN_wSuy31gX-_51z8uby4P79Ob--ubs7PblObqyymts6oQisLq7VFYiRCskVb5KppKqkLWVUEWQFtLYuqblVdlw0wKrJEqi7zuTieelfe_VtziGbZBct9TwO7dTCox5V1WY0xF0df0Ae39sM43ZaSpSxzNVI4Uda7EDy3ZuW7JflXg2A29s1k34z2zca-2TQfvjev6yU3_1986B6BbALCeDX8Zf_p629b3wDgDpEs</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Murillo, Oscar</creator><creator>Grau, Imma</creator><creator>Gomez-Junyent, Joan</creator><creator>Cabrera, Celina</creator><creator>Ribera, Alba</creator><creator>Tubau, Fe</creator><creator>Peña, Carmen</creator><creator>Ariza, Javier</creator><creator>Pallares, Roman</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton</title><author>Murillo, Oscar ; Grau, Imma ; Gomez-Junyent, Joan ; Cabrera, Celina ; Ribera, Alba ; Tubau, Fe ; Peña, Carmen ; Ariza, Javier ; Pallares, Roman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-cb2a81c64c99c1ae1aa1ac4f437dd8694688a0240fb648bf7bb5d0e17acaa7b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arthritis</topic><topic>Axial skeleton</topic><topic>Bacteria</topic><topic>Biocompatibility</topic><topic>Bone diseases</topic><topic>Coagulase</topic><topic>Echocardiography</topic><topic>Endocarditis</topic><topic>Family Medicine</topic><topic>General Practice</topic><topic>Infectious Diseases</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microorganisms</topic><topic>Observational studies</topic><topic>Original Paper</topic><topic>Osteomyelitis</topic><topic>Patients</topic><topic>Sepsis</topic><topic>Vertebrae</topic><topic>Vertebral osteomyelitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murillo, Oscar</creatorcontrib><creatorcontrib>Grau, Imma</creatorcontrib><creatorcontrib>Gomez-Junyent, Joan</creatorcontrib><creatorcontrib>Cabrera, Celina</creatorcontrib><creatorcontrib>Ribera, Alba</creatorcontrib><creatorcontrib>Tubau, Fe</creatorcontrib><creatorcontrib>Peña, Carmen</creatorcontrib><creatorcontrib>Ariza, Javier</creatorcontrib><creatorcontrib>Pallares, Roman</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murillo, Oscar</au><au>Grau, Imma</au><au>Gomez-Junyent, Joan</au><au>Cabrera, Celina</au><au>Ribera, Alba</au><au>Tubau, Fe</au><au>Peña, Carmen</au><au>Ariza, Javier</au><au>Pallares, Roman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton</atitle><jtitle>Infection</jtitle><stitle>Infection</stitle><addtitle>Infection</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>46</volume><issue>2</issue><spage>245</spage><epage>251</epage><pages>245-251</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>Purpose
The relationship between infective endocarditis (IE) and osteoarticular infections (OAIs) are not well known. We aimed to study the characteristics of patients with IE and OAIs, and the interactions between these two infections.
Methods
An observational study (1993–2014) which includes two cohorts: (1) patients with IE (
n
= 607) and (2) patients with bacteremic OAIs (
n
= 458; septic arthritis of peripheral and axial skeleton, and vertebral and peripheral osteomyelitis). These two cohorts were prospectively collected, and we retrospectively reviewed the clinical and microbiological variables.
Results
There were 70 cases of IE with concomitant OAIs, representing 11.5% of IE cases and 15% of bacteremic OAI cases. Among cases with IE, the associated OAIs mainly involved the axial skeleton (
n
= 54, 77%): 43 were vertebral osteomyelitis (61%), mainly caused by “less virulent” bacteria (
viridans
and
bovis
streptococci, enterococci, and coagulase-negative staphylococci), and 15 were septic arthritis of the axial skeleton (21%), which were mainly caused by
Staphylococcus aureus
. OAIs with involvement of the axial skeleton were associated with IE (adjusted OR = 2.2; 95% CI 1.1–4.3) independently of age, sex, and microorganisms.
Conclusions
Among patients with IE, the associated OAIs mainly involve the axial skeleton. Transesophageal echocardiography should be carefully considered in patients presenting with these bacteremic OAIs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29396671</pmid><doi>10.1007/s15010-018-1121-9</doi><tpages>7</tpages></addata></record> |
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| ispartof | Infection, 2018-04, Vol.46 (2), p.245-251 |
| issn | 0300-8126 1439-0973 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1993995899 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Arthritis Axial skeleton Bacteria Biocompatibility Bone diseases Coagulase Echocardiography Endocarditis Family Medicine General Practice Infectious Diseases Internal Medicine Medicine Medicine & Public Health Microorganisms Observational studies Original Paper Osteomyelitis Patients Sepsis Vertebrae Vertebral osteomyelitis |
| title | Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton |
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