High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

mRNA processing, transport, translation, and ultimately degradation involve a series of dedicated protein complexes that often assemble into large membraneless structures such as stress granules (SGs) and processing bodies (PBs). Here, systematic in vivo proximity-dependent biotinylation (BioID) ana...

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Veröffentlicht in:	Molecular cell 2018-02, Vol.69 (3), p.517-532.e11
Hauptverfasser:	Youn, Ji-Young, Dunham, Wade H., Hong, Seo Jung, Knight, James D.R., Bashkurov, Mikhail, Chen, Ginny I., Bagci, Halil, Rathod, Bhavisha, MacLeod, Graham, Eng, Simon W.M., Angers, Stéphane, Morris, Quaid, Fabian, Marc, Côté, Jean-François, Gingras, Anne-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	BioID Carrier Proteins - metabolism Cytoplasm - metabolism Cytoplasm - ultrastructure Cytoplasmic Granules - metabolism DNA-Binding Proteins - metabolism Humans Intracellular Space mass spectrometry membraneless organelle PP4 complex processing body Proteins - metabolism proximity-based labeling PRRC2C ribonucleoprotein complex RNA - metabolism RNA, Messenger - metabolism RNA-Binding Proteins - metabolism stress granule Stress, Physiological UBAP2L
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