PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

The inflammatory response mediated by nuclear factor κB (NF-κB) signaling is essential for host defense against pathogens. Although the regulatory mechanism of NF-κB signaling has been well studied, the molecular basis for epigenetic regulation of the inflammatory response is poorly understood. Here...

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Veröffentlicht in:	Molecular cell 2018-02, Vol.69 (3), p.398-411.e6
Hauptverfasser:	Kim, Dongha, Nam, Hye Jin, Lee, Wonhwa, Yim, Hwa Young, Ahn, Jun-Yeong, Park, Se Won, Shin, Hi-Jai R., Yu, Reynold, Won, Kyoung-Jae, Bae, Jong-Sup, Kim, Keun Il, Baek, Sung Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals C/EBPδ Cell Nucleus - metabolism Epigenesis, Genetic - genetics epigenetic regulation Go6976 GSK-LSD1 Histone Demethylases - genetics Histone Demethylases - metabolism inflammation Inflammation - metabolism LSD1 Methylation Mice Mice, Inbred C57BL NF-kappa B - metabolism NF-κB signaling p65 Phosphorylation PKCα Protein Kinase C - genetics Protein Kinase C - metabolism Protein-Serine-Threonine Kinases - metabolism sepsis Signal Transduction - genetics Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - metabolism
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