Novel identification of STAT1 as a crucial mediator of ETV6-NTRK3-induced tumorigenesis

Chromosomal rearrangements that facilitate tumor formation and progression through activation of oncogenic tyrosine kinases are frequently observed in cancer. The ETV6-NTRK3 (EN) fusion has been implicated in various cancers, including infantile fibrosarcoma, secretory breast carcinoma, and acute my...

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Veröffentlicht in:	Oncogene 2018-04, Vol.37 (17), p.2270-2284
Hauptverfasser:	Park, Jinah, Kim, Junil, Park, Bora, Yang, Kyung-Min, Sun, Eun Jin, Tognon, Cristina E., Sorensen, Poul H., Kim, Seong-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 13/95 38/109 38/39 38/61 38/91 631/337/458/1733 631/67/395 82/80 Acetylation Acute myeloid leukemia Apoptosis Breast cancer Breast carcinoma Carcinogenesis Cell adhesion Cell Biology Cell proliferation Chromosome rearrangements DNA microarrays Fibroblasts Fibrosarcoma Gene expression Genetic aspects Health aspects Human chromosomes Human Genetics Identification and classification Internal Medicine Kinases Medicine Medicine & Public Health NF-κB protein Nuclear transport Oncology Phosphorylation Ribonucleic acid RNA RNA sequencing Signal transduction Stat1 protein Structure Transcription factors Tumorigenesis Tyrosine
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