Low serum vitamin D levels in patients with myasthenia gravis
•The autoantibody response in myasthenia gravis is T cell dependent.•The regulatory T cell has been shown functionally defective in MG patients.•The immune-regulatory effect of vitamin D is known to induce the regulatory T cells.•Plasma 25(OH)D levels were significantly lower in patients with MG pat...
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| Veröffentlicht in: | Journal of clinical neuroscience 2018-04, Vol.50, p.294-297 |
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| creator | Kang, Sa-Yoon Kang, Ji-Hoon Choi, Jay Chol Song, Sook Keun Oh, Jung-Hwan |
| description | •The autoantibody response in myasthenia gravis is T cell dependent.•The regulatory T cell has been shown functionally defective in MG patients.•The immune-regulatory effect of vitamin D is known to induce the regulatory T cells.•Plasma 25(OH)D levels were significantly lower in patients with MG patients.
Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease. Vitamin D has important roles both in the autoimmune response and in skeletal muscles. We investigated the levels of 1,25-dihydroxy vitamin D [1,25(OH)2D] and 25-hydroxy vitamin D [25(OH)D] in patients with MG and healthy subjects. MG patients were classified by disease stage, age of onset and treatment status whether or not to taking immunosuppressive agents. MG patients had lower plasma 25(OH)D levels (mean, 18.8 ± 8.4 ng/mL) than healthy controls (26.3 ± 6.1 ng/mL) (p |
| doi_str_mv | 10.1016/j.jocn.2018.01.047 |
| format | Article |
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Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease. Vitamin D has important roles both in the autoimmune response and in skeletal muscles. We investigated the levels of 1,25-dihydroxy vitamin D [1,25(OH)2D] and 25-hydroxy vitamin D [25(OH)D] in patients with MG and healthy subjects. MG patients were classified by disease stage, age of onset and treatment status whether or not to taking immunosuppressive agents. MG patients had lower plasma 25(OH)D levels (mean, 18.8 ± 8.4 ng/mL) than healthy controls (26.3 ± 6.1 ng/mL) (p < .05). 1,25(OH)2D levels showed slightly high in MG patients than healthy controls, but had no significant difference between two groups. In addition, no significant differences were observed between two groups divided by clinical characteristics. Serum 25(OH)D levels significantly lower in patients with MG compared with healthy controls. We recommend monitoring of vitamin D status in patients with MG to avoid direct negative effects on the muscles or autoimmune response.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2018.01.047</identifier><identifier>PMID: 29396067</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>25(OH)D ; Autoimmunity ; Calcitriol - blood ; Female ; Humans ; Male ; Middle Aged ; Muscle ; Myasthenia gravis ; Myasthenia Gravis - blood ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Journal of clinical neuroscience, 2018-04, Vol.50, p.294-297</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-72f80f8d85f4b1473c5a8073814dbf00fa96fc6794d4d83357dbc7f9ce05db803</citedby><cites>FETCH-LOGICAL-c356t-72f80f8d85f4b1473c5a8073814dbf00fa96fc6794d4d83357dbc7f9ce05db803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jocn.2018.01.047$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29396067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Sa-Yoon</creatorcontrib><creatorcontrib>Kang, Ji-Hoon</creatorcontrib><creatorcontrib>Choi, Jay Chol</creatorcontrib><creatorcontrib>Song, Sook Keun</creatorcontrib><creatorcontrib>Oh, Jung-Hwan</creatorcontrib><title>Low serum vitamin D levels in patients with myasthenia gravis</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>•The autoantibody response in myasthenia gravis is T cell dependent.•The regulatory T cell has been shown functionally defective in MG patients.•The immune-regulatory effect of vitamin D is known to induce the regulatory T cells.•Plasma 25(OH)D levels were significantly lower in patients with MG patients.
Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease. Vitamin D has important roles both in the autoimmune response and in skeletal muscles. We investigated the levels of 1,25-dihydroxy vitamin D [1,25(OH)2D] and 25-hydroxy vitamin D [25(OH)D] in patients with MG and healthy subjects. MG patients were classified by disease stage, age of onset and treatment status whether or not to taking immunosuppressive agents. MG patients had lower plasma 25(OH)D levels (mean, 18.8 ± 8.4 ng/mL) than healthy controls (26.3 ± 6.1 ng/mL) (p < .05). 1,25(OH)2D levels showed slightly high in MG patients than healthy controls, but had no significant difference between two groups. In addition, no significant differences were observed between two groups divided by clinical characteristics. Serum 25(OH)D levels significantly lower in patients with MG compared with healthy controls. We recommend monitoring of vitamin D status in patients with MG to avoid direct negative effects on the muscles or autoimmune response.</description><subject>25(OH)D</subject><subject>Autoimmunity</subject><subject>Calcitriol - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - blood</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EglL4AwwoI0vCdZz4IcGAylOqxAKz5fhBXeVR7DRV_z2pWhiZ7hm-c6T7IXSFIcOA6e0yW3a6zXLAPAOcQcGO0ASXJE9zWpJjNAFBWVpyys_QeYxLABAFgVN0lgsiKFA2QffzbpNEG9ZNMvheNb5NHpPaDraOyZhXqve27WOy8f0iabYq9gvbepV8BTX4eIFOnKqjvTzcKfp8fvqYvabz95e32cM81aSkfcpyx8Fxw0tXVLhgRJeKAyMcF6ZyAE4J6jRlojCF4YSUzFSaOaEtlKbiQKboZr-7Ct332sZeNj5qW9eqtd06SizGh0TOeT6i-R7VoYsxWCdXwTcqbCUGudMml3KnTe60ScBy1DaWrg_766qx5q_y62kE7vbA6MUO3gYZ9ShGW-OD1b00nf9v_wd9cX3x</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Kang, Sa-Yoon</creator><creator>Kang, Ji-Hoon</creator><creator>Choi, Jay Chol</creator><creator>Song, Sook Keun</creator><creator>Oh, Jung-Hwan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>Low serum vitamin D levels in patients with myasthenia gravis</title><author>Kang, Sa-Yoon ; Kang, Ji-Hoon ; Choi, Jay Chol ; Song, Sook Keun ; Oh, Jung-Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-72f80f8d85f4b1473c5a8073814dbf00fa96fc6794d4d83357dbc7f9ce05db803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>25(OH)D</topic><topic>Autoimmunity</topic><topic>Calcitriol - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle</topic><topic>Myasthenia gravis</topic><topic>Myasthenia Gravis - blood</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Sa-Yoon</creatorcontrib><creatorcontrib>Kang, Ji-Hoon</creatorcontrib><creatorcontrib>Choi, Jay Chol</creatorcontrib><creatorcontrib>Song, Sook Keun</creatorcontrib><creatorcontrib>Oh, Jung-Hwan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Sa-Yoon</au><au>Kang, Ji-Hoon</au><au>Choi, Jay Chol</au><au>Song, Sook Keun</au><au>Oh, Jung-Hwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum vitamin D levels in patients with myasthenia gravis</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2018-04</date><risdate>2018</risdate><volume>50</volume><spage>294</spage><epage>297</epage><pages>294-297</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>•The autoantibody response in myasthenia gravis is T cell dependent.•The regulatory T cell has been shown functionally defective in MG patients.•The immune-regulatory effect of vitamin D is known to induce the regulatory T cells.•Plasma 25(OH)D levels were significantly lower in patients with MG patients.
Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease. Vitamin D has important roles both in the autoimmune response and in skeletal muscles. We investigated the levels of 1,25-dihydroxy vitamin D [1,25(OH)2D] and 25-hydroxy vitamin D [25(OH)D] in patients with MG and healthy subjects. MG patients were classified by disease stage, age of onset and treatment status whether or not to taking immunosuppressive agents. MG patients had lower plasma 25(OH)D levels (mean, 18.8 ± 8.4 ng/mL) than healthy controls (26.3 ± 6.1 ng/mL) (p < .05). 1,25(OH)2D levels showed slightly high in MG patients than healthy controls, but had no significant difference between two groups. In addition, no significant differences were observed between two groups divided by clinical characteristics. Serum 25(OH)D levels significantly lower in patients with MG compared with healthy controls. We recommend monitoring of vitamin D status in patients with MG to avoid direct negative effects on the muscles or autoimmune response.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>29396067</pmid><doi>10.1016/j.jocn.2018.01.047</doi><tpages>4</tpages></addata></record> |
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| subjects | 25(OH)D Autoimmunity Calcitriol - blood Female Humans Male Middle Aged Muscle Myasthenia gravis Myasthenia Gravis - blood Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Low serum vitamin D levels in patients with myasthenia gravis |
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