Mitosis count and number of cancer cells in cases of primary pulmonary adenocarcinoma: Correlations among phosphorylated histone 3, number of cancer cells, nuclear grade, pathologic features and prognosis
Immunohistochemistry findings for the phosphorylated form of histone 3 (pHH3) have been shown to be a reliable mitosis‐specific marker. We evaluated the correlation between pHH3‐stained mitotic figures (PHMFs) and clinical outcome, and compared the results with findings for numbers of PHMFs and canc...
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| Veröffentlicht in: | Pathology international 2018-03, Vol.68 (3), p.159-166 |
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| creator | Inoue, Takashi Nakazato, Yoshimasa Karube, Yoko Maeda, Sumiko Kobayashi, Satoru Chida, Masayuki |
| description | Immunohistochemistry findings for the phosphorylated form of histone 3 (pHH3) have been shown to be a reliable mitosis‐specific marker. We evaluated the correlation between pHH3‐stained mitotic figures (PHMFs) and clinical outcome, and compared the results with findings for numbers of PHMFs and cancer cells. The primary tumor was obtained from 113 patients with pulmonary adenocarcinomas (≤2 cm maximum dimension). All specimens were stained with pHH3, then the number of cancer cells in each was determined. Cases with a cancer‐cell index ≥1000 showed worse recurrence‐free survival as compared to those with a value |
| doi_str_mv | 10.1111/pin.12635 |
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We evaluated the correlation between pHH3‐stained mitotic figures (PHMFs) and clinical outcome, and compared the results with findings for numbers of PHMFs and cancer cells. The primary tumor was obtained from 113 patients with pulmonary adenocarcinomas (≤2 cm maximum dimension). All specimens were stained with pHH3, then the number of cancer cells in each was determined. Cases with a cancer‐cell index ≥1000 showed worse recurrence‐free survival as compared to those with a value <1000 (P < 0.001). Also, cases with a pHH3 index ≥0.27 showed worse recurrence‐free survival as compared to <0.27 (P = 0.001) and cases with a pHH3/cancer‐cell index ≥0.001 showed worse recurrence‐free survival as compared to <0.001 (P = 0.002). Multivariate analysis demonstrated that pHH3/cancer‐cell index was significantly correlated with prognosis, but not Ki‐67 index. The number of cancer cells was also strongly correlated with progression of Noguchi's classification and WHO pathologic type. pHH3/cancer‐cell index was correlated with prognosis, and those were useful for prognostic evaluation of pulmonary adenocarcinoma patients. Furthermore, cancer cell number was correlated with Noguchi's classification and WHO pathologic type.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1111/pin.12635</identifier><identifier>PMID: 29393583</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adenocarcinoma of Lung ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Cancer ; Cell number ; Classification ; Female ; histological classification ; Histones - metabolism ; Humans ; Immunohistochemistry ; Ki-67 Antigen - metabolism ; Lung cancer ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Medical prognosis ; Middle Aged ; Mitosis ; Mitosis - physiology ; Mitotic Index - methods ; Multivariate analysis ; nuclear grading ; Patients ; phosphorylated histone 3 ; Phosphorylation ; Prognosis ; pulmonary adenocarcinoma ; Survival</subject><ispartof>Pathology international, 2018-03, Vol.68 (3), p.159-166</ispartof><rights>2018 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd</rights><rights>2018 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3775-d57321f4a9719b533f9c96488ded265644e14e411293affea10e4f242fbb77ff3</citedby><cites>FETCH-LOGICAL-c3775-d57321f4a9719b533f9c96488ded265644e14e411293affea10e4f242fbb77ff3</cites><orcidid>0000-0001-8502-1502</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpin.12635$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpin.12635$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29393583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Takashi</creatorcontrib><creatorcontrib>Nakazato, Yoshimasa</creatorcontrib><creatorcontrib>Karube, Yoko</creatorcontrib><creatorcontrib>Maeda, Sumiko</creatorcontrib><creatorcontrib>Kobayashi, Satoru</creatorcontrib><creatorcontrib>Chida, Masayuki</creatorcontrib><title>Mitosis count and number of cancer cells in cases of primary pulmonary adenocarcinoma: Correlations among phosphorylated histone 3, number of cancer cells, nuclear grade, pathologic features and prognosis</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>Immunohistochemistry findings for the phosphorylated form of histone 3 (pHH3) have been shown to be a reliable mitosis‐specific marker. We evaluated the correlation between pHH3‐stained mitotic figures (PHMFs) and clinical outcome, and compared the results with findings for numbers of PHMFs and cancer cells. The primary tumor was obtained from 113 patients with pulmonary adenocarcinomas (≤2 cm maximum dimension). All specimens were stained with pHH3, then the number of cancer cells in each was determined. Cases with a cancer‐cell index ≥1000 showed worse recurrence‐free survival as compared to those with a value <1000 (P < 0.001). Also, cases with a pHH3 index ≥0.27 showed worse recurrence‐free survival as compared to <0.27 (P = 0.001) and cases with a pHH3/cancer‐cell index ≥0.001 showed worse recurrence‐free survival as compared to <0.001 (P = 0.002). Multivariate analysis demonstrated that pHH3/cancer‐cell index was significantly correlated with prognosis, but not Ki‐67 index. The number of cancer cells was also strongly correlated with progression of Noguchi's classification and WHO pathologic type. pHH3/cancer‐cell index was correlated with prognosis, and those were useful for prognostic evaluation of pulmonary adenocarcinoma patients. Furthermore, cancer cell number was correlated with Noguchi's classification and WHO pathologic type.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of Lung</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cell number</subject><subject>Classification</subject><subject>Female</subject><subject>histological classification</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mitosis</subject><subject>Mitosis - physiology</subject><subject>Mitotic Index - methods</subject><subject>Multivariate analysis</subject><subject>nuclear grading</subject><subject>Patients</subject><subject>phosphorylated histone 3</subject><subject>Phosphorylation</subject><subject>Prognosis</subject><subject>pulmonary adenocarcinoma</subject><subject>Survival</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdtu1DAQhiMEoqVwwQsgS9yA1LQ-JV5zh1YcKpXDBVxbjjPedZXYwU6E9h15KCbswgVSLVkejz_983umqp4zesVwXU8hXjHeiuZBdc6kpDXbcPUQY8Fp3chWnFVPSrmjlCnR0sfVGddCi2Yjzqtfn8KcSijEpSXOxMaexGXsIJPkibPRYeRgGAoJEe8Fyvow5TDafCDTMowprpHtISZnswsxjfYN2aacYbBzSLEQi9COTPtUcOcDpqEn-1DmFIGIy3sqrnk3gM1kl1H-kkx23qch7YIjHuy8ZDSzGp5y2sX1E0-rR94OBZ6dzovq-_t337Yf69svH262b29rJ5Rq6r5RgjMvrVZMd40QXjvdys2mh563TSslMAmSMWyT9ViKUZCeS-67TinvxUX16qiLlX8sUGYzhrJ6thHSUgzT2F_NlFKIvvwPvUtLjujOcEp1w3mjJFKvj5TLqZQM3pw6bBg164gNjtj8GTGyL06KSzdC_4_8O1MEro_AzzDA4X4l8_Xm81HyN3TdtE4</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Inoue, Takashi</creator><creator>Nakazato, Yoshimasa</creator><creator>Karube, Yoko</creator><creator>Maeda, Sumiko</creator><creator>Kobayashi, Satoru</creator><creator>Chida, Masayuki</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8502-1502</orcidid></search><sort><creationdate>201803</creationdate><title>Mitosis count and number of cancer cells in cases of primary pulmonary adenocarcinoma: Correlations among phosphorylated histone 3, number of cancer cells, nuclear grade, pathologic features and prognosis</title><author>Inoue, Takashi ; Nakazato, Yoshimasa ; Karube, Yoko ; Maeda, Sumiko ; Kobayashi, Satoru ; Chida, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3775-d57321f4a9719b533f9c96488ded265644e14e411293affea10e4f242fbb77ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of Lung</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cell number</topic><topic>Classification</topic><topic>Female</topic><topic>histological classification</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Mitosis</topic><topic>Mitosis - physiology</topic><topic>Mitotic Index - methods</topic><topic>Multivariate analysis</topic><topic>nuclear grading</topic><topic>Patients</topic><topic>phosphorylated histone 3</topic><topic>Phosphorylation</topic><topic>Prognosis</topic><topic>pulmonary adenocarcinoma</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Takashi</creatorcontrib><creatorcontrib>Nakazato, Yoshimasa</creatorcontrib><creatorcontrib>Karube, Yoko</creatorcontrib><creatorcontrib>Maeda, Sumiko</creatorcontrib><creatorcontrib>Kobayashi, Satoru</creatorcontrib><creatorcontrib>Chida, Masayuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Takashi</au><au>Nakazato, Yoshimasa</au><au>Karube, Yoko</au><au>Maeda, Sumiko</au><au>Kobayashi, Satoru</au><au>Chida, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitosis count and number of cancer cells in cases of primary pulmonary adenocarcinoma: Correlations among phosphorylated histone 3, number of cancer cells, nuclear grade, pathologic features and prognosis</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2018-03</date><risdate>2018</risdate><volume>68</volume><issue>3</issue><spage>159</spage><epage>166</epage><pages>159-166</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>Immunohistochemistry findings for the phosphorylated form of histone 3 (pHH3) have been shown to be a reliable mitosis‐specific marker. We evaluated the correlation between pHH3‐stained mitotic figures (PHMFs) and clinical outcome, and compared the results with findings for numbers of PHMFs and cancer cells. The primary tumor was obtained from 113 patients with pulmonary adenocarcinomas (≤2 cm maximum dimension). All specimens were stained with pHH3, then the number of cancer cells in each was determined. Cases with a cancer‐cell index ≥1000 showed worse recurrence‐free survival as compared to those with a value <1000 (P < 0.001). Also, cases with a pHH3 index ≥0.27 showed worse recurrence‐free survival as compared to <0.27 (P = 0.001) and cases with a pHH3/cancer‐cell index ≥0.001 showed worse recurrence‐free survival as compared to <0.001 (P = 0.002). Multivariate analysis demonstrated that pHH3/cancer‐cell index was significantly correlated with prognosis, but not Ki‐67 index. The number of cancer cells was also strongly correlated with progression of Noguchi's classification and WHO pathologic type. pHH3/cancer‐cell index was correlated with prognosis, and those were useful for prognostic evaluation of pulmonary adenocarcinoma patients. Furthermore, cancer cell number was correlated with Noguchi's classification and WHO pathologic type.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29393583</pmid><doi>10.1111/pin.12635</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8502-1502</orcidid></addata></record> |
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| ispartof | Pathology international, 2018-03, Vol.68 (3), p.159-166 |
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| subjects | Adenocarcinoma Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Cancer Cell number Classification Female histological classification Histones - metabolism Humans Immunohistochemistry Ki-67 Antigen - metabolism Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical prognosis Middle Aged Mitosis Mitosis - physiology Mitotic Index - methods Multivariate analysis nuclear grading Patients phosphorylated histone 3 Phosphorylation Prognosis pulmonary adenocarcinoma Survival |
| title | Mitosis count and number of cancer cells in cases of primary pulmonary adenocarcinoma: Correlations among phosphorylated histone 3, number of cancer cells, nuclear grade, pathologic features and prognosis |
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