Cocaine induces a differential dose-dependent alteration in the expression profile of immediate early genes, transcription factors, and caspases in PC12 cells: a possible mechanism of neurotoxic damage in cocaine addiction

Cocaine is a widely used drug of abuse and psychostimulant that acts on the central nervous system by blocking the dopamine reuptake sites. PC12 cells, a rat pheochromocytoma clonal line, in the presence of nerve growth factor (NGF), multiply and differentiate into competent neurons that can synthes...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2005-08, Vol.1053 (1), p.482-490
Hauptverfasser:	Imam, Syed Z, Duhart, Helen M, Skinner, John T, Ali, Syed F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Apoptosis - physiology Blotting, Western Caspases - biosynthesis Chromatography, High Pressure Liquid Cocaine - pharmacology Cocaine-Related Disorders - pathology Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Genes, Immediate-Early - genetics NF-kappa B - biosynthesis NF-kappa B - genetics PC12 Cells Rats Transcription Factor AP-1 - biosynthesis Transcription Factor AP-1 - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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