Novel camptothecin analogues that circumvent ABCG2‐associated drug resistance in human tumor cells

Irinotecan (7‐ethyl‐10‐[4‐(1‐piperidino)‐1‐piperidino]‐carbonyloxycamptothecin; CPT‐11) is a widely used potent antitumor drug that inhibits mammalian DNA topoisomerase I (Topo I); however, overexpression of ABCG2 (BCRP/MXR/ABCP) can confer cancer cell resistance to SN‐38, the active form of CPT‐11....

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Veröffentlicht in:	International journal of cancer 2004-07, Vol.110 (6), p.921-927
Hauptverfasser:	Yoshikawa, Megumi, Ikegami, Yoji, Hayasaka, Shinya, Ishii, Kazuyuki, Ito, Akiko, Sano, Kazumi, Suzuki, Toshihiro, Togawa, Tadayasu, Yoshida, Hisahiro, Soda, Hiroshi, Oka, Mikio, Kohno, Shigeru, Sawada, Seigo, Ishikawa, Toshihisa, Tanabe, Shinzo
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 Adenosine Triphosphate - metabolism Antineoplastic agents Antineoplastic Agents - toxicity ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - genetics Biological and medical sciences Biological Transport Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Camptothecin - toxicity Carcinoma, Small Cell Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - physiology Cloning, Molecular CPT analogue DNA topoisomerase I inhibitor Drug Resistance, Neoplasm - drug effects General aspects Humans Lung Neoplasms Medical sciences Neoplasm Proteins - genetics Pharmacology. Drug treatments Recombinant Proteins - metabolism SAR SN‐38 Structure-Activity Relationship Tumors
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