Cobalt-Catalyzed Remote C‑4 Functionalization of 8‑Aminoquinoline Amides with Ethers via C–H Activation under Visible-Light Irradiation. Access to α‑Heteroarylated Ether Derivatives

A cobalt-catalyzed selective remote C-4 alkylation of 8-aminoquinoline amides via C–H activation under irradiation with a CFL lamp in the presence of eosin Y at room temperature has been achieved. A series of pharmaceutically important C-4 quinoline amide-substituted ether derivatives has been obtained by this procedure. The C-4 functionalization of quinoline amides with inert ether is of much significance and was not reported earlier.