Aberrant DNA Methylation in Chronic Myeloid Leukemia: Cell Fate Control, Prognosis, and Therapeutic Response

Chronic myeloid leukemia (CML) is a hematopoietic stem cell malignancy characterized by the expression of the BCR–ABL1 fusion gene with different chimeric transcripts. Despite the crucial impact of constitutively active tyrosine kinase in CML pathogenesis, aberrant DNA methylation of certain genes p...

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Veröffentlicht in:	Biochemical genetics 2018-06, Vol.56 (3), p.149-175
Hauptverfasser:	Behzad, Masumeh Maleki, Shahrabi, Saeid, Jaseb, Kaveh, Bertacchini, Jessika, Ketabchi, Neda, Saki, Najmaldin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Apoptosis Biochemistry Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cell fate Cell Proliferation Cell survival Chronic myeloid leukemia Deoxyribonucleic acid Disease-Free Survival DNA DNA Methylation DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Drug resistance Fusion protein Gene expression Genes Hematopoietic stem cells Human Genetics Humans Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - mortality Malignancy Medical Microbiology Medical prognosis Myeloid leukemia Pathogenesis Prognosis Protein-tyrosine kinase Review Signaling Stem cells Survival Rate Tyrosine Zoology
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