Carboxyl-Photo-Reactive MS-Cleavable Cross-Linkers: Unveiling a Hidden Aspect of Diazirine-Based Reagents

A major challenge in cross-linking/mass spectrometry (MS) is targeting carboxyl functions in proteins under physiological conditions that do not disturb the protein’s conformation. Cross-linking of glutamic acid and aspartic acid residues in proteins will greatly expand the scope of structural mass...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-02, Vol.90 (4), p.2805-2809
Hauptverfasser:	Iacobucci, Claudio, Götze, Michael, Piotrowski, Christine, Arlt, Christian, Rehkamp, Anne, Ihling, Christian, Hage, Christoph, Sinz, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Aspartic acid Carboxylic acids Chemistry Crosslinking Esters Glutamic acid Inserts Mass spectrometry Mass spectroscopy Photoactivation Protein structure Proteins Reagents Software Software development tools Spectroscopy
Online-Zugang:	Volltext
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