Salvinorin A ameliorates cerebral vasospasm through activation of endothelial nitric oxide synthase in a rat model of subarachnoid hemorrhage

Objective This study aimed to demonstrate the potential of salvinorin A (SA) for cerebral vasospasm after subarachnoid hemorrhage (SAH) and investigate mechanisms of therapeutic effect using rat SAH model. Methods Salvinorin A was injected intraperitoneally, and the neurobehavioral changes were obse...

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Veröffentlicht in:	Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2018-04, Vol.25 (3), p.e12442-n/a
Hauptverfasser:	Sun, Juan, Zhang, Yan, Lu, Jianfei, Zhang, Weiguang, Yan, Junhao, Yang, Lei, Zhou, Changman, Liu, Renyu, Chen, Chunhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysms Animals Apoptosis Aquaporin 4 - drug effects Aquaporin 4 - metabolism aquaporin‐4 Basilar Artery - diagnostic imaging cerebral vasospasm Diterpenes, Clerodane - pharmacology Diterpenes, Clerodane - therapeutic use Endothelin-1 - drug effects Endothelin-1 - metabolism eNOS Morphology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - drug effects Nitric Oxide Synthase Type III - metabolism NMR Nuclear magnetic resonance Protein expression Proteins Rats Rodents salvinorin A subarachnoid hemorrhage Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - drug therapy Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - prevention & control
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