The effect of maternal exposure to di‐(2‐ethylhexyl)‐phthalate on fetal cardiac development in mice

Accumulating evidence has suggested a link between maternal di‐(2‐ethylhexyl)‐phthalate (DEHP) exposure and various developmental abnormalities. However, the evidence regarding the effect of maternal DEHP exposure on fetal cardiac development is scarce. The present study aimed to determine the effec...

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Veröffentlicht in:	Journal of applied toxicology 2018-06, Vol.38 (6), p.834-842
Hauptverfasser:	Tang, Changqing, Deng, Yuxin, Duan, Hongyu, Zhang, Yi, Li, Yifei, Qiu, Dajian, Zhou, Kaiyu, Hua, Yimin, Wang, Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Body weight cardiac development Chf1 Corn oil Diethylhexyl Phthalate - toxicity di‐(2‐ethylhexyl)‐phthalate Embryos Exposure Female Fetal Heart - drug effects Fetal Heart - growth & development Fetal Heart - metabolism Fetuses Fuel consumption Gata4 GATA4 Transcription Factor - genetics GATA4 Transcription Factor - metabolism Gene expression Gene Expression Regulation, Developmental Gestational Age Heart Defects, Congenital - chemically induced Heart Defects, Congenital - genetics Heart Defects, Congenital - metabolism Heart Defects, Congenital - physiopathology Heart diseases Heart rate Hypoplasia Maternal Exposure MEF2 Transcription Factors - genetics MEF2 Transcription Factors - metabolism Mef2c Mice Mice, Inbred C57BL Morphogenesis - drug effects mRNA Myocardium Nkx2.5 protein Peroxisome proliferator-activated receptors Placenta Plasticizers - toxicity Polymerase chain reaction PPAR gamma - agonists PPAR gamma - genetics PPAR gamma - metabolism PPARγ Pregnancy Repressor Proteins - genetics Repressor Proteins - metabolism Rodents Signal Transduction - drug effects Ventricle
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