Mechanisms of Dorsal Root Ganglion Stimulation in Pain Suppression: A Computational Modeling Analysis

Objective The mechanisms of dorsal root ganglion (DRG) stimulation for chronic pain remain unclear. The objective of this work was to explore the neurophysiological effects of DRG stimulation using computational modeling. Methods Electrical fields produced during DRG stimulation were calculated with...

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Veröffentlicht in:	Neuromodulation (Malden, Mass.) Mass.), 2018-04, Vol.21 (3), p.234-246
Hauptverfasser:	Kent, Alexander R., Min, Xiaoyi, Hogan, Quinn H., Kramer, Jeffery M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Animals Calcium conductance Chronic pain Computational modeling Computational neuroscience Computer Simulation Dorsal root ganglia DRG stimulation ectopic activity Electric Stimulation Therapy Finite Element Analysis Ganglia, Spinal - physiology Humans Hyperpolarization mechanisms of action Membrane potential Neuralgia - physiopathology Neurons - physiology Polarity Potassium channels Potassium conductance Sensory neurons T‐junction filtering
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