Overweight in childhood cancer survivors: the Swiss Childhood Cancer Survivor Study

ABSTRACT Background An increased risk of becoming overweight has been reported for childhood cancer survivors (CCSs), in particular leukemia survivors, although the evidence is inconclusive. Objective We assessed the prevalence of overweight in CCSs, with a focus on leukemia survivors, compared it w...

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Veröffentlicht in:The American journal of clinical nutrition 2018-01, Vol.107 (1), p.3-11
Hauptverfasser: Belle, Fabiën N, Weiss, Annette, Schindler, Matthias, Goutaki, Myrofora, Bochud, Murielle, Zimmermann, Karin, von der Weid, Nicolas, Ammann, Roland A, Kuehni, Claudia E
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container_title The American journal of clinical nutrition
container_volume 107
creator Belle, Fabiën N
Weiss, Annette
Schindler, Matthias
Goutaki, Myrofora
Bochud, Murielle
Zimmermann, Karin
von der Weid, Nicolas
Ammann, Roland A
Kuehni, Claudia E
description ABSTRACT Background An increased risk of becoming overweight has been reported for childhood cancer survivors (CCSs), in particular leukemia survivors, although the evidence is inconclusive. Objective We assessed the prevalence of overweight in CCSs, with a focus on leukemia survivors, compared it with their peers, and determined potential risk factors. Design As part of the Swiss Childhood Cancer Survivor Study, we sent a questionnaire between 2007 and 2013 to all Swiss resident CCSs aged
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Objective We assessed the prevalence of overweight in CCSs, with a focus on leukemia survivors, compared it with their peers, and determined potential risk factors. Design As part of the Swiss Childhood Cancer Survivor Study, we sent a questionnaire between 2007 and 2013 to all Swiss resident CCSs aged &lt;21 y at diagnosis who had survived ≥5 y. We calculated body mass index (BMI) from medical records at diagnosis and self-reported heights and weights at survey. We calculated BMI z scores by using Swiss references for children and compared overweight prevalence in CCSs, their siblings, and the general population with the use of the Swiss Health Survey (SHS) and assessed risk factors for being overweight by using multivariable logistic regression. Results The study included 2365 CCSs, 819 siblings, and 9591 SHS participants. At survey, at an average of 15 y after diagnosis, the prevalence of overweight in CCSs overall (26%) and in leukemia survivors (26%) was similar to that in siblings (22%) and the general population (25%). Risk factors for being overweight in CCSs were male sex (OR: 1.8; 95% CI: 1.5, 2.1), both young (OR for ages 5–14 y: 1.6; 95% CI: 1.2, 2.3) and older (range—OR for ages 25–29 y: 1.7; 95% CI: 1.2, 2.4; OR for ages 40–45 y: 4.0; 95% CI: 2.5, 6.5) age at study, lower education (OR: 1.4; 95% CI: 1.1, 1.8), migration background (OR: 1.3; 95% CI: 1.1, 1.7), and no sports participation (OR: 1.4; 95% CI: 1.1, 1.7). Risk factors for overweight were similar in peers. CCSs treated with cranial radiotherapy (≥20 Gy) were more likely to be overweight than their peers (OR: 1.6; 95% CI: 1.2, 2.2). Conclusions The prevalence of and risk factors for being overweight are similar in long-term CCSs and their peers. This suggests that prevention methods can be the same as in the general population. An important exception is CCSs treated with cranial radiotherapy ≥20 Gy who may need extra attention during follow-up care. This study was registered at clinicaltrials.gov as NCT03297034.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/nqx006</identifier><identifier>PMID: 29381792</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; Age ; Body Mass Index ; Body size ; Body weight ; Cancer ; Cancer Survivors ; Child ; Child, Preschool ; Childhood ; Children ; Children &amp; youth ; Design factors ; Diagnosis ; Female ; Follow-Up Studies ; Humans ; Leukemia ; Leukemia - diagnosis ; Leukemia - radiotherapy ; Logistic Models ; Male ; Mathematical analysis ; Medical Records ; Middle Aged ; Migration ; Obesity ; Overweight ; Overweight - epidemiology ; Prevalence ; Radiation therapy ; Retrospective Studies ; Risk analysis ; Risk assessment ; Risk Factors ; Siblings ; Skull ; Socioeconomic Factors ; Surveys and Questionnaires ; Survivor ; Switzerland - epidemiology ; Young Adult</subject><ispartof>The American journal of clinical nutrition, 2018-01, Vol.107 (1), p.3-11</ispartof><rights>2018 American Society for Nutrition. All rights reserved. 2018</rights><rights>2018 American Society for Nutrition. All rights reserved.</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jan 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-7c0367dc05d629f4d22debb32eb8208edd13db2cf0237edbe3abd9ac85a164623</citedby><cites>FETCH-LOGICAL-c385t-7c0367dc05d629f4d22debb32eb8208edd13db2cf0237edbe3abd9ac85a164623</cites><orcidid>0000-0002-0037-4817 ; 0000-0001-8036-2092 ; 0000-0002-5727-0218 ; 0000-0001-8957-2002 ; 0000-0001-8295-3574 ; 0000-0002-1902-2352 ; 0000-0001-7232-693X ; 0000-0002-9555-3817</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29381792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belle, Fabiën N</creatorcontrib><creatorcontrib>Weiss, Annette</creatorcontrib><creatorcontrib>Schindler, Matthias</creatorcontrib><creatorcontrib>Goutaki, Myrofora</creatorcontrib><creatorcontrib>Bochud, Murielle</creatorcontrib><creatorcontrib>Zimmermann, Karin</creatorcontrib><creatorcontrib>von der Weid, Nicolas</creatorcontrib><creatorcontrib>Ammann, Roland A</creatorcontrib><creatorcontrib>Kuehni, Claudia E</creatorcontrib><title>Overweight in childhood cancer survivors: the Swiss Childhood Cancer Survivor Study</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>ABSTRACT Background An increased risk of becoming overweight has been reported for childhood cancer survivors (CCSs), in particular leukemia survivors, although the evidence is inconclusive. Objective We assessed the prevalence of overweight in CCSs, with a focus on leukemia survivors, compared it with their peers, and determined potential risk factors. Design As part of the Swiss Childhood Cancer Survivor Study, we sent a questionnaire between 2007 and 2013 to all Swiss resident CCSs aged &lt;21 y at diagnosis who had survived ≥5 y. We calculated body mass index (BMI) from medical records at diagnosis and self-reported heights and weights at survey. We calculated BMI z scores by using Swiss references for children and compared overweight prevalence in CCSs, their siblings, and the general population with the use of the Swiss Health Survey (SHS) and assessed risk factors for being overweight by using multivariable logistic regression. Results The study included 2365 CCSs, 819 siblings, and 9591 SHS participants. At survey, at an average of 15 y after diagnosis, the prevalence of overweight in CCSs overall (26%) and in leukemia survivors (26%) was similar to that in siblings (22%) and the general population (25%). Risk factors for being overweight in CCSs were male sex (OR: 1.8; 95% CI: 1.5, 2.1), both young (OR for ages 5–14 y: 1.6; 95% CI: 1.2, 2.3) and older (range—OR for ages 25–29 y: 1.7; 95% CI: 1.2, 2.4; OR for ages 40–45 y: 4.0; 95% CI: 2.5, 6.5) age at study, lower education (OR: 1.4; 95% CI: 1.1, 1.8), migration background (OR: 1.3; 95% CI: 1.1, 1.7), and no sports participation (OR: 1.4; 95% CI: 1.1, 1.7). Risk factors for overweight were similar in peers. CCSs treated with cranial radiotherapy (≥20 Gy) were more likely to be overweight than their peers (OR: 1.6; 95% CI: 1.2, 2.2). Conclusions The prevalence of and risk factors for being overweight are similar in long-term CCSs and their peers. This suggests that prevention methods can be the same as in the general population. An important exception is CCSs treated with cranial radiotherapy ≥20 Gy who may need extra attention during follow-up care. 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Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belle, Fabiën N</au><au>Weiss, Annette</au><au>Schindler, Matthias</au><au>Goutaki, Myrofora</au><au>Bochud, Murielle</au><au>Zimmermann, Karin</au><au>von der Weid, Nicolas</au><au>Ammann, Roland A</au><au>Kuehni, Claudia E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overweight in childhood cancer survivors: the Swiss Childhood Cancer Survivor Study</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>107</volume><issue>1</issue><spage>3</spage><epage>11</epage><pages>3-11</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>ABSTRACT Background An increased risk of becoming overweight has been reported for childhood cancer survivors (CCSs), in particular leukemia survivors, although the evidence is inconclusive. Objective We assessed the prevalence of overweight in CCSs, with a focus on leukemia survivors, compared it with their peers, and determined potential risk factors. Design As part of the Swiss Childhood Cancer Survivor Study, we sent a questionnaire between 2007 and 2013 to all Swiss resident CCSs aged &lt;21 y at diagnosis who had survived ≥5 y. We calculated body mass index (BMI) from medical records at diagnosis and self-reported heights and weights at survey. We calculated BMI z scores by using Swiss references for children and compared overweight prevalence in CCSs, their siblings, and the general population with the use of the Swiss Health Survey (SHS) and assessed risk factors for being overweight by using multivariable logistic regression. Results The study included 2365 CCSs, 819 siblings, and 9591 SHS participants. At survey, at an average of 15 y after diagnosis, the prevalence of overweight in CCSs overall (26%) and in leukemia survivors (26%) was similar to that in siblings (22%) and the general population (25%). Risk factors for being overweight in CCSs were male sex (OR: 1.8; 95% CI: 1.5, 2.1), both young (OR for ages 5–14 y: 1.6; 95% CI: 1.2, 2.3) and older (range—OR for ages 25–29 y: 1.7; 95% CI: 1.2, 2.4; OR for ages 40–45 y: 4.0; 95% CI: 2.5, 6.5) age at study, lower education (OR: 1.4; 95% CI: 1.1, 1.8), migration background (OR: 1.3; 95% CI: 1.1, 1.7), and no sports participation (OR: 1.4; 95% CI: 1.1, 1.7). Risk factors for overweight were similar in peers. CCSs treated with cranial radiotherapy (≥20 Gy) were more likely to be overweight than their peers (OR: 1.6; 95% CI: 1.2, 2.2). Conclusions The prevalence of and risk factors for being overweight are similar in long-term CCSs and their peers. This suggests that prevention methods can be the same as in the general population. An important exception is CCSs treated with cranial radiotherapy ≥20 Gy who may need extra attention during follow-up care. This study was registered at clinicaltrials.gov as NCT03297034.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>29381792</pmid><doi>10.1093/ajcn/nqx006</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0037-4817</orcidid><orcidid>https://orcid.org/0000-0001-8036-2092</orcidid><orcidid>https://orcid.org/0000-0002-5727-0218</orcidid><orcidid>https://orcid.org/0000-0001-8957-2002</orcidid><orcidid>https://orcid.org/0000-0001-8295-3574</orcidid><orcidid>https://orcid.org/0000-0002-1902-2352</orcidid><orcidid>https://orcid.org/0000-0001-7232-693X</orcidid><orcidid>https://orcid.org/0000-0002-9555-3817</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Age
Body Mass Index
Body size
Body weight
Cancer
Cancer Survivors
Child
Child, Preschool
Childhood
Children
Children & youth
Design factors
Diagnosis
Female
Follow-Up Studies
Humans
Leukemia
Leukemia - diagnosis
Leukemia - radiotherapy
Logistic Models
Male
Mathematical analysis
Medical Records
Middle Aged
Migration
Obesity
Overweight
Overweight - epidemiology
Prevalence
Radiation therapy
Retrospective Studies
Risk analysis
Risk assessment
Risk Factors
Siblings
Skull
Socioeconomic Factors
Surveys and Questionnaires
Survivor
Switzerland - epidemiology
Young Adult
title Overweight in childhood cancer survivors: the Swiss Childhood Cancer Survivor Study
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