YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma

Activation of YAP, a Hippo pathway effector, is an important resistance mechanism to BRAF inhibitor (BRAFi) in melanoma. Emerging evidence also suggests that YAP is involved in suppression of the antitumor immune response. However, the potential direct impact of YAP activity on cytotoxic T-cell immu...

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Veröffentlicht in:	Cancer immunology research 2018-03, Vol.6 (3), p.255-266
Hauptverfasser:	Kim, Min Hwan, Kim, Chang Gon, Kim, Sang-Kyum, Shin, Sang Joon, Choe, Eun Ah, Park, Su-Hyung, Shin, Eui-Cheol, Kim, Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - immunology B7-H1 Antigen - immunology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cell Survival - drug effects Drug Resistance, Neoplasm Humans Immune Evasion Melanoma - drug therapy Melanoma - immunology Phosphoproteins - immunology Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - antagonists & inhibitors Transcription Factors Tumor Escape
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