Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung

Cadmium is an environmentally widely dispersed and highly toxic heavy metal that has been classified as a human carcinogen. Using the suppression subtractive hybridization technique, we identified previously 29 cadmium-inducible genes, primarily involved in inflammation, cell survival and apoptosis....

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Veröffentlicht in:	Carcinogenesis (New York) 2004-08, Vol.25 (8), p.1467-1475
Hauptverfasser:	Shin, Hye-Jin, Lee, Byung-Hoon, Yeo, Myeong Goo, Oh, Seon-Hee, Park, Jung-Duck, Park, Kun-Koo, Chung, Jin-Ho, Moon, Chang-Kiu, Lee, Mi-Ock
Format:	Artikel
Sprache:	eng
Schlagworte:	5-dimethylthiazol-2-yl)-2 5-diphenyl tetrazolium bromide 6-diamidino-2-phenylindole Animals Apoptosis bcl-2-Associated X Protein Biological and medical sciences Cadmium - metabolism Carcinogenesis, carcinogens and anticarcinogens Cell Line, Tumor Cell Survival Chemical and industrial products toxicology. Toxic occupational diseases Cyclic AMP-Dependent Protein Kinases - metabolism DAPI DNA-Binding Proteins - biosynthesis Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology ERK extracellular signal-regulated kinase Female Flavonoids - pharmacology Gene Expression Regulation Genes, Reporter Humans Immunohistochemistry Inflammation Isoquinolines - pharmacology Lung - pathology MAPK Medical sciences Metals and various inorganic compounds mitogen-activated protein kinase Mitogen-Activated Protein Kinases - metabolism MTT NBRE Nuclear Receptor Subfamily 4, Group A, Member 1 Nucleic Acid Hybridization Nur77-binding response element PBMC PBS peripheral blood mononuclear cells phosphate-buffered saline PKA Plasmids - metabolism Precipitin Tests protein kinase A Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear Receptors, Steroid Reverse Transcriptase Polymerase Chain Reaction RT–PCT Signal Transduction Sulfonamides T-cell receptor TCR Time Factors Toxicology Transcription Factors - biosynthesis Transfection Tumors
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