Changes in cecal microbial metabolism of rats induced by individual and a mixture of drinking water disinfection by-products

Disinfection of drinking water has been one of the greatest public health successes. Numerous halogenated disinfection by-products (DBPs) occur and chronic ingestion has been associated with an increased risk for colorectal cancer in human populations. Because the intestinal microbiota can bioactiva...

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Veröffentlicht in:	Cancer letters 2004-02, Vol.204 (1), p.15-21
Hauptverfasser:	George, S.E., Wolf, D.C., Brooks, L.R., Bailey, K.C., Hooth, M.J., Nelson, G.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Bacteria - drug effects Bacteria - metabolism Bacterial metabolism beta-Galactosidase - metabolism beta-Glucosidase - metabolism Body Weight - drug effects Bromates - toxicity Carcinogens Cecum - microbiology Chemicals Chloroform - toxicity Colon Disinfection Drinking water Drug Combinations Enzymes Furans - toxicity Glucuronidase - metabolism Heterozygote Laboratory animals Male Metabolism Metabolites Mixture Mutagens - toxicity NADH, NADPH Oxidoreductases - metabolism Nitroreductases - metabolism Potassium Rats Rats, Long-Evans Repressor Proteins - genetics Repressor Proteins - physiology Rodents Studies Trihalomethanes - toxicity Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins Tumors Water Water Pollutants, Chemical - toxicity
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