TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma

The anti-metastatic effect of 4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid (TAC-101) was investigated using our established intrahepatic metastasis model. Orthotopic implantation of a fragment of CBO140C12 hepatoma into the liver resulted in the formation of a solitary tumor nodule and its intra...

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Veröffentlicht in:	Cancer letters 2003-08, Vol.198 (2), p.169-177
Hauptverfasser:	Lee, Soo Jin, Ohashi, Yasukata, Sakurai, Hiroaki, Saiki, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - administration & dosage Anticarcinogenic Agents - pharmacology Antineoplastic agents AP-1 Base Sequence Benzoates - administration & dosage Benzoates - pharmacology Binding sites Biological and medical sciences Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - prevention & control Cell Division - drug effects Cell Movement - drug effects Disease Models, Animal DNA Primers Drug Implants Experiments Genes Hepatocellular carcinoma Intrahepatic metastasis Liver cancer Liver Neoplasms - chemically induced Liver Neoplasms - pathology Liver Neoplasms - prevention & control Liver Neoplasms - secondary Medical prognosis Medical sciences Mice Mice, Inbred Strains Migration Neoplasm Invasiveness Neoplasm Metastasis - prevention & control Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction Rodents TAC-101 Transcription Factor AP-1 - antagonists & inhibitors Transcription Factor AP-1 - drug effects Transcription Factor AP-1 - metabolism Transcription factors Trimethylsilyl Compounds - administration & dosage Trimethylsilyl Compounds - pharmacology Tumor Cells, Cultured Tumors u-PA
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