Cell Type–Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease—Brief Report

OBJECTIVE—Two were the aims of this studyfirst, to translate whole-genome expression profiles into computational predictions of functional associations between signaling pathways that regulate aorta homeostasis and the activity of angiotensin II type 1a receptor (At1ar) in either vascular endothelia...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-03, Vol.38 (3), p.588-591
Hauptverfasser:	Galatioto, Josephine, Caescu, Cristina I, Hansen, Jens, Cook, Jason R, Miramontes, Irving, Iyengar, Ravi, Ramirez, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Aortic Aneurysm, Thoracic - genetics Aortic Aneurysm, Thoracic - metabolism Aortic Aneurysm, Thoracic - pathology Aortic Aneurysm, Thoracic - physiopathology Computational Biology Dilatation, Pathologic Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Fibrillin-1 - genetics Fibrillin-1 - metabolism Gene Expression Profiling - methods Gene Expression Regulation Homeostasis Male Marfan Syndrome - genetics Marfan Syndrome - metabolism Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Receptor, Angiotensin, Type 1 - deficiency Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Signal Transduction
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