Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis

[Display omitted] Novel reversed isoniazid (RINH) agents were synthesized by covalently linking isoniazid with various efflux pump inhibitor (EPI) cores and their structural motifs. These RINH agents were then evaluated for anti-mycobacterial activity against sensitive, isoniazid mono-resistant and...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-02, Vol.26 (4), p.833-844
Hauptverfasser:	Kumar, Malkeet, Singh, Kawaljit, Ngwane, Andile H., Hamzabegovic, Fahreta, Abate, Getahun, Baker, Bienyameen, Wiid, Ian, Hoft, Daniel F., Ruminski, Peter, Chibale, Kelly
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemosensitizers Efflux pump inhibitors Efflux pumps Ethidium bromide M. tuberculosis Macrophages
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!