Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer
Purpose We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC). Methods Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/P...
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| Veröffentlicht in: | Endocrine 2018-03, Vol.59 (3), p.565-572 |
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| creator | Tam, Abbas Ali Ozdemir, Didem Aydın, Cevdet Bestepe, Nagihan Ulusoy, Serap Sungu, Nuran Ersoy, Reyhan Cakir, Bekir |
| description | Purpose
We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC).
Methods
Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone and patients with tumors known to be unresponsive to TSH were excluded.
Results
Data of 1632 patients were analyzed. Histopathological diagnosis was benign in 969 (59.4%) and malignant in 663 (40.6%) patients. Preoperative median serum TSH was significantly higher in malignant compared to benign group (1.41 IU/dL vs. 0.98 IU/dL,
p
|
| doi_str_mv | 10.1007/s12020-018-1523-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1992004641</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1992004641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-f894e5360a92a8bf1ba1fe18ca42e42c654785c640d86a4ede5f1eabadc72f5d3</originalsourceid><addsrcrecordid>eNp1kUtr3DAUhUVpaNIkP6CbYsimGydXL8tehtAXBLpJIDshy1czCh7JleyU-ffVxGkLga4kHX3n6IpDyAcKlxRAXWXKgEENtK2pZLxu3pATKmVXFIC3Zc-lrAHah2PyPudHAMZYo96RY9ZxJbhQJ2R_nXO03sw-hqrH-RdiqKaEccJUxCes5u0-xTnFaetDZcJQ2dEHb-Nk5m0c48ZbMz7rZrNJmPPB49DMSzlU0VWTmfw4mrRfk3wJMMFiOiNHzowZz1_WU3L_5fPdzbf69sfX7zfXt7Xlis21azuBkjdgOmba3tHeUIe0tUYwFMw2UqhW2kbA0DZG4IDSUTS9GaxiTg78lHxac6cUfy6YZ73z2WIZKWBcsqZdxwBEI2hBL16hj3FJoUynC6IUcEl5oehK2RRzTuj0lPyufFBT0Ide9NqLLr3oQy-6KZ6PL8lLv8Phr-NPEQVgK5DLVdhg-vf0_1N_AxK3m6s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2007703513</pqid></control><display><type>article</type><title>Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Tam, Abbas Ali ; Ozdemir, Didem ; Aydın, Cevdet ; Bestepe, Nagihan ; Ulusoy, Serap ; Sungu, Nuran ; Ersoy, Reyhan ; Cakir, Bekir</creator><creatorcontrib>Tam, Abbas Ali ; Ozdemir, Didem ; Aydın, Cevdet ; Bestepe, Nagihan ; Ulusoy, Serap ; Sungu, Nuran ; Ersoy, Reyhan ; Cakir, Bekir</creatorcontrib><description>Purpose
We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC).
Methods
Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone and patients with tumors known to be unresponsive to TSH were excluded.
Results
Data of 1632 patients were analyzed. Histopathological diagnosis was benign in 969 (59.4%) and malignant in 663 (40.6%) patients. Preoperative median serum TSH was significantly higher in malignant compared to benign group (1.41 IU/dL vs. 0.98 IU/dL,
p
< 0.001). Malignancy risk increased gradually as going from hyperthyroidism to euthyroidism and hypothyroidism (20, 40.6, and 59.1%, respectively,
p
< 0.05). Serum TSH was lowest in benign nodular disease, higher in PTMC and highest in PTC (
p
< 0.001). This was also true when patients with positive antithyroid peroxidase/antithyroglobulin and with lymphocytic thyroiditis were excluded from the analysis (
p
< 0.001). Serum TSH was higher in patients with bilateral tumor, capsular invasion and lymph node metastasis (LNM) compared to patients with unilateral tumor, without capsule invasion and without LNM, respectively (
p
= 0.036,
p
= 0.002, and
p
= 0.001, respectively). Patients with aggressive variant PTC had higher serum TSH than nonaggressive ones (
p
< 0.05).
Conclusion
Preoperative serum TSH is associated with PTMC, PTC and LNM. Serum TSH seems to be related with thyroid cancer regardless of autoimmunity. With the present study, for the first time, we showed an association between serum TSH and aggressive variants of PTC.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-018-1523-6</identifier><identifier>PMID: 29374347</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Autoimmunity ; Benign ; Carcinoma, Papillary - blood ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - surgery ; Diabetes ; Endocrinology ; Female ; Humanities and Social Sciences ; Humans ; Hyperthyroidism ; Hypothyroidism ; Internal Medicine ; Lymph nodes ; Male ; Malignancy ; Medicine ; Medicine & Public Health ; Metastases ; Middle Aged ; multidisciplinary ; Original Article ; Papillary thyroid cancer ; Papillary thyroid carcinoma ; Peroxidase ; Science ; Surgery ; Thyroid cancer ; Thyroid Gland - pathology ; Thyroid Gland - surgery ; Thyroid Neoplasms - blood ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroid-stimulating hormone ; Thyroidectomy ; Thyroiditis ; Thyrotropin - blood ; Treatment Outcome ; Tumors ; Young Adult</subject><ispartof>Endocrine, 2018-03, Vol.59 (3), p.565-572</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Nature B.V. 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f894e5360a92a8bf1ba1fe18ca42e42c654785c640d86a4ede5f1eabadc72f5d3</citedby><cites>FETCH-LOGICAL-c372t-f894e5360a92a8bf1ba1fe18ca42e42c654785c640d86a4ede5f1eabadc72f5d3</cites><orcidid>0000-0003-4552-1603</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-018-1523-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-018-1523-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29374347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tam, Abbas Ali</creatorcontrib><creatorcontrib>Ozdemir, Didem</creatorcontrib><creatorcontrib>Aydın, Cevdet</creatorcontrib><creatorcontrib>Bestepe, Nagihan</creatorcontrib><creatorcontrib>Ulusoy, Serap</creatorcontrib><creatorcontrib>Sungu, Nuran</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><title>Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC).
Methods
Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone and patients with tumors known to be unresponsive to TSH were excluded.
Results
Data of 1632 patients were analyzed. Histopathological diagnosis was benign in 969 (59.4%) and malignant in 663 (40.6%) patients. Preoperative median serum TSH was significantly higher in malignant compared to benign group (1.41 IU/dL vs. 0.98 IU/dL,
p
< 0.001). Malignancy risk increased gradually as going from hyperthyroidism to euthyroidism and hypothyroidism (20, 40.6, and 59.1%, respectively,
p
< 0.05). Serum TSH was lowest in benign nodular disease, higher in PTMC and highest in PTC (
p
< 0.001). This was also true when patients with positive antithyroid peroxidase/antithyroglobulin and with lymphocytic thyroiditis were excluded from the analysis (
p
< 0.001). Serum TSH was higher in patients with bilateral tumor, capsular invasion and lymph node metastasis (LNM) compared to patients with unilateral tumor, without capsule invasion and without LNM, respectively (
p
= 0.036,
p
= 0.002, and
p
= 0.001, respectively). Patients with aggressive variant PTC had higher serum TSH than nonaggressive ones (
p
< 0.05).
Conclusion
Preoperative serum TSH is associated with PTMC, PTC and LNM. Serum TSH seems to be related with thyroid cancer regardless of autoimmunity. With the present study, for the first time, we showed an association between serum TSH and aggressive variants of PTC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoimmunity</subject><subject>Benign</subject><subject>Carcinoma, Papillary - blood</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Hypothyroidism</subject><subject>Internal Medicine</subject><subject>Lymph nodes</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Papillary thyroid cancer</subject><subject>Papillary thyroid carcinoma</subject><subject>Peroxidase</subject><subject>Science</subject><subject>Surgery</subject><subject>Thyroid cancer</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Gland - surgery</subject><subject>Thyroid Neoplasms - blood</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroidectomy</subject><subject>Thyroiditis</subject><subject>Thyrotropin - blood</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtr3DAUhUVpaNIkP6CbYsimGydXL8tehtAXBLpJIDshy1czCh7JleyU-ffVxGkLga4kHX3n6IpDyAcKlxRAXWXKgEENtK2pZLxu3pATKmVXFIC3Zc-lrAHah2PyPudHAMZYo96RY9ZxJbhQJ2R_nXO03sw-hqrH-RdiqKaEccJUxCes5u0-xTnFaetDZcJQ2dEHb-Nk5m0c48ZbMz7rZrNJmPPB49DMSzlU0VWTmfw4mrRfk3wJMMFiOiNHzowZz1_WU3L_5fPdzbf69sfX7zfXt7Xlis21azuBkjdgOmba3tHeUIe0tUYwFMw2UqhW2kbA0DZG4IDSUTS9GaxiTg78lHxac6cUfy6YZ73z2WIZKWBcsqZdxwBEI2hBL16hj3FJoUynC6IUcEl5oehK2RRzTuj0lPyufFBT0Ide9NqLLr3oQy-6KZ6PL8lLv8Phr-NPEQVgK5DLVdhg-vf0_1N_AxK3m6s</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Tam, Abbas Ali</creator><creator>Ozdemir, Didem</creator><creator>Aydın, Cevdet</creator><creator>Bestepe, Nagihan</creator><creator>Ulusoy, Serap</creator><creator>Sungu, Nuran</creator><creator>Ersoy, Reyhan</creator><creator>Cakir, Bekir</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4552-1603</orcidid></search><sort><creationdate>20180301</creationdate><title>Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer</title><author>Tam, Abbas Ali ; Ozdemir, Didem ; Aydın, Cevdet ; Bestepe, Nagihan ; Ulusoy, Serap ; Sungu, Nuran ; Ersoy, Reyhan ; Cakir, Bekir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-f894e5360a92a8bf1ba1fe18ca42e42c654785c640d86a4ede5f1eabadc72f5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoimmunity</topic><topic>Benign</topic><topic>Carcinoma, Papillary - blood</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hyperthyroidism</topic><topic>Hypothyroidism</topic><topic>Internal Medicine</topic><topic>Lymph nodes</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Papillary thyroid cancer</topic><topic>Papillary thyroid carcinoma</topic><topic>Peroxidase</topic><topic>Science</topic><topic>Surgery</topic><topic>Thyroid cancer</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Gland - surgery</topic><topic>Thyroid Neoplasms - blood</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroidectomy</topic><topic>Thyroiditis</topic><topic>Thyrotropin - blood</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tam, Abbas Ali</creatorcontrib><creatorcontrib>Ozdemir, Didem</creatorcontrib><creatorcontrib>Aydın, Cevdet</creatorcontrib><creatorcontrib>Bestepe, Nagihan</creatorcontrib><creatorcontrib>Ulusoy, Serap</creatorcontrib><creatorcontrib>Sungu, Nuran</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tam, Abbas Ali</au><au>Ozdemir, Didem</au><au>Aydın, Cevdet</au><au>Bestepe, Nagihan</au><au>Ulusoy, Serap</au><au>Sungu, Nuran</au><au>Ersoy, Reyhan</au><au>Cakir, Bekir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>59</volume><issue>3</issue><spage>565</spage><epage>572</epage><pages>565-572</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC).
Methods
Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone and patients with tumors known to be unresponsive to TSH were excluded.
Results
Data of 1632 patients were analyzed. Histopathological diagnosis was benign in 969 (59.4%) and malignant in 663 (40.6%) patients. Preoperative median serum TSH was significantly higher in malignant compared to benign group (1.41 IU/dL vs. 0.98 IU/dL,
p
< 0.001). Malignancy risk increased gradually as going from hyperthyroidism to euthyroidism and hypothyroidism (20, 40.6, and 59.1%, respectively,
p
< 0.05). Serum TSH was lowest in benign nodular disease, higher in PTMC and highest in PTC (
p
< 0.001). This was also true when patients with positive antithyroid peroxidase/antithyroglobulin and with lymphocytic thyroiditis were excluded from the analysis (
p
< 0.001). Serum TSH was higher in patients with bilateral tumor, capsular invasion and lymph node metastasis (LNM) compared to patients with unilateral tumor, without capsule invasion and without LNM, respectively (
p
= 0.036,
p
= 0.002, and
p
= 0.001, respectively). Patients with aggressive variant PTC had higher serum TSH than nonaggressive ones (
p
< 0.05).
Conclusion
Preoperative serum TSH is associated with PTMC, PTC and LNM. Serum TSH seems to be related with thyroid cancer regardless of autoimmunity. With the present study, for the first time, we showed an association between serum TSH and aggressive variants of PTC.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29374347</pmid><doi>10.1007/s12020-018-1523-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4552-1603</orcidid></addata></record> |
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| ispartof | Endocrine, 2018-03, Vol.59 (3), p.565-572 |
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| subjects | Adult Aged Aged, 80 and over Autoimmunity Benign Carcinoma, Papillary - blood Carcinoma, Papillary - pathology Carcinoma, Papillary - surgery Diabetes Endocrinology Female Humanities and Social Sciences Humans Hyperthyroidism Hypothyroidism Internal Medicine Lymph nodes Male Malignancy Medicine Medicine & Public Health Metastases Middle Aged multidisciplinary Original Article Papillary thyroid cancer Papillary thyroid carcinoma Peroxidase Science Surgery Thyroid cancer Thyroid Gland - pathology Thyroid Gland - surgery Thyroid Neoplasms - blood Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroid-stimulating hormone Thyroidectomy Thyroiditis Thyrotropin - blood Treatment Outcome Tumors Young Adult |
| title | Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer |
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