Synthesis and evaluation of Novel Benzimidazole derivative [Bz-Im] and its radio/biological studies

Two different benzimidazole analogues act as multimodal agent, first one as novel non-peptidic CCK-B receptor antagonist and similarly as potent anti-fungal agent, designated as [Bz-Im]. These compounds were synthesized and characterized by spectroscopic techniques such as FT-IR, NMR, EI-MS and also...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-05, Vol.17 (10), p.2749-2755
Hauptverfasser:	Tiwari, Anjani K., Mishra, Anil K., Bajpai, Aruna, Mishra, Pushpa, Singh, Sweta, Sinha, Deepa, Singh, V.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	99mTc-labeled Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Aspergillus flavus Aspergillus niger Aspergillus niger - drug effects Benzimidazole Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Biodistribution Biological and medical sciences Contrast media. Radiopharmaceuticals Inhibitory Concentration 50 Medical sciences Microbial Sensitivity Tests Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Non-peptidic Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Rabbits Radiolabeling Radiopharmaceuticals - pharmacology Receptor, Cholecystokinin B - antagonists & inhibitors Receptors, Cholecystokinin - antagonists & inhibitors Spectroscopy
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