Vitamin A–coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease

Chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (SCT) is characterized by multiorgan fibrosis and profoundly affects the quality of life of transplant survivors. Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, plays a critical...

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Veröffentlicht in:	Blood 2018-03, Vol.131 (13), p.1476-1485
Hauptverfasser:	Yamakawa, Tomohiro, Ohigashi, Hiroyuki, Hashimoto, Daigo, Hayase, Eiko, Takahashi, Shuichiro, Miyazaki, Miyono, Minomi, Kenjiro, Onozawa, Masahiro, Niitsu, Yoshiro, Teshima, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals Chronic Disease Collagen Female Fibrosis Graft vs Host Disease - drug therapy Graft vs Host Disease - genetics Graft vs Host Disease - pathology Hematopoietic Stem Cell Transplantation HSP47 Heat-Shock Proteins - antagonists & inhibitors HSP47 Heat-Shock Proteins - genetics HSP47 Heat-Shock Proteins - metabolism Liposomes Macrophages - metabolism Macrophages - pathology Mice Mice, Inbred BALB C Myofibroblasts - metabolism Myofibroblasts - pathology RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Skin Diseases - drug therapy Skin Diseases - genetics Skin Diseases - metabolism Skin Diseases - pathology Vitamin A - pharmacology
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