Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals
In the murine model, it was demonstrated that pro‐inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma‐induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally inf...
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| Veröffentlicht in: | Scandinavian journal of immunology 2018-03, Vol.87 (3), p.n/a |
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| creator | Rodrigues Oliveira, J. L. Teixeira, M. M. Lambertucci, J. R. Antunes, C. M. F. Carneiro, M. Negrão‐Corrêa, D. |
| description | In the murine model, it was demonstrated that pro‐inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma‐induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally infected individuals. The current study evaluates the association between plasma concentrations of MIF, sTNF‐R1, CCL3, CCL7 and CCL24 and schistosomiasis morbidity in Schistosoma mansoni‐infected patients with a low parasite burden. For this propose, 97 S. mansoni‐infected individuals were subjected to abdominal ultrasound analysis and clinical examination. Among them, 88 had plasma concentration of immune mediators estimated by ELISA assay. Multivariate linear regression models were used to evaluate the relationship between the plasma concentration of immune mediators and the variables investigated. Although most individuals presented low parasite burden, over 30% of them showed signs of fibrosis defined by ultrasound measurements and 2 patients had a severe form of schistosomiasis. No association between parasite burden and the plasma levels of chemokine/cytokines or disease severity was observed. There was a positive association between plasma concentration of CCL4, sTNF‐R1, CCL3 and MIF with gall bladder thickness and/or with portal vein thickness that are liver fibrosis markers. In contrast, no association was found between CCL7 plasma concentrations with any of the schistosomiasis morbidity parameters evaluated. The data showed that CCL24, sTNFR1, MIF and CCL3 can be detected in plasma of S. mansoni‐infected individuals and their concentration would be used as prognostic makers of Schistosoma‐induced liver fibrosis, even in individuals with low parasite burden. |
| doi_str_mv | 10.1111/sji.12642 |
| format | Article |
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L. ; Teixeira, M. M. ; Lambertucci, J. R. ; Antunes, C. M. F. ; Carneiro, M. ; Negrão‐Corrêa, D.</creator><creatorcontrib>Rodrigues Oliveira, J. L. ; Teixeira, M. M. ; Lambertucci, J. R. ; Antunes, C. M. F. ; Carneiro, M. ; Negrão‐Corrêa, D.</creatorcontrib><description>In the murine model, it was demonstrated that pro‐inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma‐induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally infected individuals. The current study evaluates the association between plasma concentrations of MIF, sTNF‐R1, CCL3, CCL7 and CCL24 and schistosomiasis morbidity in Schistosoma mansoni‐infected patients with a low parasite burden. For this propose, 97 S. mansoni‐infected individuals were subjected to abdominal ultrasound analysis and clinical examination. Among them, 88 had plasma concentration of immune mediators estimated by ELISA assay. Multivariate linear regression models were used to evaluate the relationship between the plasma concentration of immune mediators and the variables investigated. Although most individuals presented low parasite burden, over 30% of them showed signs of fibrosis defined by ultrasound measurements and 2 patients had a severe form of schistosomiasis. No association between parasite burden and the plasma levels of chemokine/cytokines or disease severity was observed. There was a positive association between plasma concentration of CCL4, sTNF‐R1, CCL3 and MIF with gall bladder thickness and/or with portal vein thickness that are liver fibrosis markers. In contrast, no association was found between CCL7 plasma concentrations with any of the schistosomiasis morbidity parameters evaluated. The data showed that CCL24, sTNFR1, MIF and CCL3 can be detected in plasma of S. mansoni‐infected individuals and their concentration would be used as prognostic makers of Schistosoma‐induced liver fibrosis, even in individuals with low parasite burden.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/sji.12642</identifier><identifier>PMID: 29363152</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Animal models ; Animals ; blood ; Carbon tetrachloride ; CCL3 protein ; CCL4 protein ; Chemokine CCL24 - blood ; Chemokine CCL3 - blood ; Chemokine CCL7 - blood ; Chemokines ; Cytokines ; Enzyme-linked immunosorbent assay ; Fibrosis ; human ; Humans ; infections ; Inflammation ; Intramolecular Oxidoreductases - blood ; Liver ; Liver - blood supply ; Liver - parasitology ; Liver - pathology ; Liver Cirrhosis - immunology ; Liver Cirrhosis - parasitology ; Macrophage Migration-Inhibitory Factors - blood ; Middle Aged ; molecules ; Morbidity ; Parasites ; parasitic ; Plasma ; Plasma levels ; Portal vein ; Portal Vein - pathology ; processes ; Receptors, Tumor Necrosis Factor, Type I - blood ; Regression analysis ; Schistosoma ; Schistosoma mansoni ; Schistosoma mansoni - immunology ; Schistosomiasis ; Schistosomiasis mansoni - immunology ; Schistosomiasis mansoni - parasitology ; subject ; tissues ; Ultrasonic imaging ; Ultrasound ; Urinary bladder ; Young Adult</subject><ispartof>Scandinavian journal of immunology, 2018-03, Vol.87 (3), p.n/a</ispartof><rights>2018 The Foundation for the Scandinavian Journal of Immunology</rights><rights>2018 The Foundation for the Scandinavian Journal of Immunology.</rights><rights>Copyright © 2018 The Foundation for the Scandinavian Journal of Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-3cf30e4b5864474af9610a4508d6236957fb75c6d8fbc02d912fcedea170d6883</citedby><cites>FETCH-LOGICAL-c3882-3cf30e4b5864474af9610a4508d6236957fb75c6d8fbc02d912fcedea170d6883</cites><orcidid>0000-0001-7670-5216</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsji.12642$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsji.12642$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29363152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodrigues Oliveira, J. L.</creatorcontrib><creatorcontrib>Teixeira, M. M.</creatorcontrib><creatorcontrib>Lambertucci, J. R.</creatorcontrib><creatorcontrib>Antunes, C. M. F.</creatorcontrib><creatorcontrib>Carneiro, M.</creatorcontrib><creatorcontrib>Negrão‐Corrêa, D.</creatorcontrib><title>Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>In the murine model, it was demonstrated that pro‐inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma‐induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally infected individuals. The current study evaluates the association between plasma concentrations of MIF, sTNF‐R1, CCL3, CCL7 and CCL24 and schistosomiasis morbidity in Schistosoma mansoni‐infected patients with a low parasite burden. For this propose, 97 S. mansoni‐infected individuals were subjected to abdominal ultrasound analysis and clinical examination. Among them, 88 had plasma concentration of immune mediators estimated by ELISA assay. Multivariate linear regression models were used to evaluate the relationship between the plasma concentration of immune mediators and the variables investigated. Although most individuals presented low parasite burden, over 30% of them showed signs of fibrosis defined by ultrasound measurements and 2 patients had a severe form of schistosomiasis. No association between parasite burden and the plasma levels of chemokine/cytokines or disease severity was observed. There was a positive association between plasma concentration of CCL4, sTNF‐R1, CCL3 and MIF with gall bladder thickness and/or with portal vein thickness that are liver fibrosis markers. In contrast, no association was found between CCL7 plasma concentrations with any of the schistosomiasis morbidity parameters evaluated. The data showed that CCL24, sTNFR1, MIF and CCL3 can be detected in plasma of S. mansoni‐infected individuals and their concentration would be used as prognostic makers of Schistosoma‐induced liver fibrosis, even in individuals with low parasite burden.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animal models</subject><subject>Animals</subject><subject>blood</subject><subject>Carbon tetrachloride</subject><subject>CCL3 protein</subject><subject>CCL4 protein</subject><subject>Chemokine CCL24 - blood</subject><subject>Chemokine CCL3 - blood</subject><subject>Chemokine CCL7 - blood</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fibrosis</subject><subject>human</subject><subject>Humans</subject><subject>infections</subject><subject>Inflammation</subject><subject>Intramolecular Oxidoreductases - blood</subject><subject>Liver</subject><subject>Liver - blood supply</subject><subject>Liver - parasitology</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - immunology</subject><subject>Liver Cirrhosis - parasitology</subject><subject>Macrophage Migration-Inhibitory Factors - blood</subject><subject>Middle Aged</subject><subject>molecules</subject><subject>Morbidity</subject><subject>Parasites</subject><subject>parasitic</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Portal vein</subject><subject>Portal Vein - pathology</subject><subject>processes</subject><subject>Receptors, Tumor Necrosis Factor, Type I - blood</subject><subject>Regression analysis</subject><subject>Schistosoma</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>Schistosomiasis mansoni - parasitology</subject><subject>subject</subject><subject>tissues</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Urinary bladder</subject><subject>Young Adult</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9qFTEUh4NY7LW68AUk4EYX0-bPTGZmKaXVloJCdT1kkhOaSya55szcS3e-QMFn9ElMvW0XgtkcAl--HH4_Qt5wdszLOcG1P-ZC1eIZWXGpmkqyTj4nKyYZq_q6bQ7JS8Q1Y1yKVr4gh6KXSvJGrMjd16Bx0jTAFgLS5KiPUc9A_TQtEegE1us5ZaQ6A9WIyZQ7WLrz8w0NfguZOj_mhB7LUxrSjm501uiLY1yyhUivzY3HOWEq_0w6Yor-989fPjow9yYfrd96u-iAr8iBKwNeP8wj8v387Nvp5-rqy6eL049XlZFdJyppnGRQj02n6rqttesVZ7puWGeVkKpvWje2jVG2c6NhwvZcOAMWNG-ZVV0nj8j7vXeT048FcB4mjwZC0BHSggPve9Y1TSvrgr77B12nJcey3SBYiVlyxUShPuwpU5LADG7YZD_pfDtwNtx3NJSOhr8dFfbtg3EZS7xP5GMpBTjZAzsf4Pb_puH68mKv_AO-_Z5F</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Rodrigues Oliveira, J. L.</creator><creator>Teixeira, M. M.</creator><creator>Lambertucci, J. R.</creator><creator>Antunes, C. M. F.</creator><creator>Carneiro, M.</creator><creator>Negrão‐Corrêa, D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7670-5216</orcidid></search><sort><creationdate>201803</creationdate><title>Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals</title><author>Rodrigues Oliveira, J. L. ; Teixeira, M. M. ; Lambertucci, J. R. ; Antunes, C. M. 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L.</au><au>Teixeira, M. M.</au><au>Lambertucci, J. R.</au><au>Antunes, C. M. F.</au><au>Carneiro, M.</au><au>Negrão‐Corrêa, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>87</volume><issue>3</issue><epage>n/a</epage><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>In the murine model, it was demonstrated that pro‐inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma‐induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally infected individuals. The current study evaluates the association between plasma concentrations of MIF, sTNF‐R1, CCL3, CCL7 and CCL24 and schistosomiasis morbidity in Schistosoma mansoni‐infected patients with a low parasite burden. For this propose, 97 S. mansoni‐infected individuals were subjected to abdominal ultrasound analysis and clinical examination. Among them, 88 had plasma concentration of immune mediators estimated by ELISA assay. Multivariate linear regression models were used to evaluate the relationship between the plasma concentration of immune mediators and the variables investigated. Although most individuals presented low parasite burden, over 30% of them showed signs of fibrosis defined by ultrasound measurements and 2 patients had a severe form of schistosomiasis. No association between parasite burden and the plasma levels of chemokine/cytokines or disease severity was observed. There was a positive association between plasma concentration of CCL4, sTNF‐R1, CCL3 and MIF with gall bladder thickness and/or with portal vein thickness that are liver fibrosis markers. In contrast, no association was found between CCL7 plasma concentrations with any of the schistosomiasis morbidity parameters evaluated. The data showed that CCL24, sTNFR1, MIF and CCL3 can be detected in plasma of S. mansoni‐infected individuals and their concentration would be used as prognostic makers of Schistosoma‐induced liver fibrosis, even in individuals with low parasite burden.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29363152</pmid><doi>10.1111/sji.12642</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7670-5216</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Animal models Animals blood Carbon tetrachloride CCL3 protein CCL4 protein Chemokine CCL24 - blood Chemokine CCL3 - blood Chemokine CCL7 - blood Chemokines Cytokines Enzyme-linked immunosorbent assay Fibrosis human Humans infections Inflammation Intramolecular Oxidoreductases - blood Liver Liver - blood supply Liver - parasitology Liver - pathology Liver Cirrhosis - immunology Liver Cirrhosis - parasitology Macrophage Migration-Inhibitory Factors - blood Middle Aged molecules Morbidity Parasites parasitic Plasma Plasma levels Portal vein Portal Vein - pathology processes Receptors, Tumor Necrosis Factor, Type I - blood Regression analysis Schistosoma Schistosoma mansoni Schistosoma mansoni - immunology Schistosomiasis Schistosomiasis mansoni - immunology Schistosomiasis mansoni - parasitology subject tissues Ultrasonic imaging Ultrasound Urinary bladder Young Adult |
| title | Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals |
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