The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the p38/MSK1/CREB/MITF axis

We recently found that treatment of normal human melanocytes (NHMs) with the antioxidant astaxanthin (AX) suppresses the stem cell factor (SCF)-stimulated protein expression levels of microphthalmia-associated transcription factor (MITF) at 1.5 h and of tyrosinase and endothelin B receptor at 96 h p...

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Veröffentlicht in:	Archives of Dermatological Research 2018-04, Vol.310 (3), p.187-196
Hauptverfasser:	Niwano, Takao, Terazawa, Shuko, Nakajima, Hiroaki, Imokawa, Genji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Astaxanthin c-Kit protein Cyclic AMP response element-binding protein Dermatology Endothelin ETB receptors Extracellular signal-regulated kinase Medicine Medicine & Public Health Melanocytes Microphthalmia-associated transcription factor Original Paper Phosphorylation Raf protein Shc protein Stem cell factor Stem cells
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