Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants
Background Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organization and cerebellar volume at term-equivalent age (TEA) in extremely preterm infa...
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| Veröffentlicht in: | Pediatric research 2018-05, Vol.83 (5), p.1004-1010 |
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| creator | Senden, Richelle E M Keunen, Kristin van der Aa, Niek E Leemans, Alexander Isgum, Ivana Viergever, Max A Dudink, Jeroen de Vries, Linda S Groenendaal, Floris Benders, Manon J N L |
| description | Background
Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organization and cerebellar volume at term-equivalent age (TEA) in extremely preterm infants. Furthermore, we aimed to evaluate the association between CBH and neurodevelopmental outcome in late infancy.
Methods
A total of 24 preterm infants with punctate CBH were included and each matched to two preterm control infants. T1-, T2-weighted images and diffusion-weighted imaging were acquired on a 3T magnetic resonance imaging (MRI) system. Regions of interest were drawn on a population-specific neonatal template and automatically registered to individual fractional anisotropy (FA) maps. Brain volumes were automatically computed. Neurodevelopmental outcome was assessed using the Bayley scales of Infant and Toddler Development at 2 years of corrected age.
Results
CBHs were not significantly related to FA in the posterior limb of the internal capsule and corpus callosum or to cerebellar volume. Infants with CBH did not have poorer neurodevelopmental outcome compared with control infants.
Conclusion
These findings suggest that the impact of mild CBH on early macroscale brain development may be limited. Future studies are needed to assess the effects of CBH on long-term neurodevelopment. |
| doi_str_mv | 10.1038/pr.2018.10 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1990851884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2040743320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-21dc1f356439295de0a96605b43b3005d8dc27171b7cfd7960fde51190f4318e3</originalsourceid><addsrcrecordid>eNp9kU-LFDEQxYMo7uzoxQ8gAS-yMmulk0x3jrL4D1a86LlJJ5XZDN1Jm6SV9WP5CU0zq4KIp-JRP94r6hHyhMElA969nNNlA6yr4h7ZMMlhB0K098kGgLMdV6o7I-c5HwGYkJ14SM4axffQgdyQHx_8aKnBhAOOo07Uh-OSbqmNmGmIhWZ_CN55o0MZb6l2Dk058UmP9NuNL0gnXQomOnmTYi5pMWVZlzEddPDfdfExUB0sDbikaPErjnGeMJSVWYqJE9ZYqqmJoeA0x6TrBSbexFRodHROWO2nyrh6RX5EHjg9Znx8N7fk85vXn67e7a4_vn1_9ep6ZwSTZdcwa5jjci-4apS0CFrt9yAHwQcOIG1nTdOylg2tcbZVe3AWJWMKnOCsQ74lz0--c4pfFsyln3w265cCxiX3TCnoJOs6UdFnf6HHuKRQr-sbvoa1qpH_pUBAKzhvoFIXJ2p9Zk7o-jn5qX6kZ9CvfVfdr32vYkue3lkuw4T2N_qr4Aq8OAG5rsIB05_Mf9j9BDXZt4A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2040743320</pqid></control><display><type>article</type><title>Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Senden, Richelle E M ; Keunen, Kristin ; van der Aa, Niek E ; Leemans, Alexander ; Isgum, Ivana ; Viergever, Max A ; Dudink, Jeroen ; de Vries, Linda S ; Groenendaal, Floris ; Benders, Manon J N L</creator><creatorcontrib>Senden, Richelle E M ; Keunen, Kristin ; van der Aa, Niek E ; Leemans, Alexander ; Isgum, Ivana ; Viergever, Max A ; Dudink, Jeroen ; de Vries, Linda S ; Groenendaal, Floris ; Benders, Manon J N L</creatorcontrib><description>Background
Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organization and cerebellar volume at term-equivalent age (TEA) in extremely preterm infants. Furthermore, we aimed to evaluate the association between CBH and neurodevelopmental outcome in late infancy.
Methods
A total of 24 preterm infants with punctate CBH were included and each matched to two preterm control infants. T1-, T2-weighted images and diffusion-weighted imaging were acquired on a 3T magnetic resonance imaging (MRI) system. Regions of interest were drawn on a population-specific neonatal template and automatically registered to individual fractional anisotropy (FA) maps. Brain volumes were automatically computed. Neurodevelopmental outcome was assessed using the Bayley scales of Infant and Toddler Development at 2 years of corrected age.
Results
CBHs were not significantly related to FA in the posterior limb of the internal capsule and corpus callosum or to cerebellar volume. Infants with CBH did not have poorer neurodevelopmental outcome compared with control infants.
Conclusion
These findings suggest that the impact of mild CBH on early macroscale brain development may be limited. Future studies are needed to assess the effects of CBH on long-term neurodevelopment.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2018.10</identifier><identifier>PMID: 29360805</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Anisotropy ; Brain - diagnostic imaging ; Brain Mapping - methods ; Case-Control Studies ; Cerebellum - diagnostic imaging ; Cerebellum - injuries ; Child, Preschool ; clinical-investigation ; Cohort Studies ; Diffusion Magnetic Resonance Imaging ; Female ; Gestational Age ; Humans ; Image Processing, Computer-Assisted - methods ; Infant ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Neurodevelopmental Disorders ; Newborn babies ; NMR ; Nuclear magnetic resonance ; Pattern Recognition, Automated ; Pediatric Surgery ; Pediatrics ; Premature babies ; Risk ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>Pediatric research, 2018-05, Vol.83 (5), p.1004-1010</ispartof><rights>International Pediatric Research Foundation, Inc. 2018</rights><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-21dc1f356439295de0a96605b43b3005d8dc27171b7cfd7960fde51190f4318e3</citedby><cites>FETCH-LOGICAL-c415t-21dc1f356439295de0a96605b43b3005d8dc27171b7cfd7960fde51190f4318e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29360805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Senden, Richelle E M</creatorcontrib><creatorcontrib>Keunen, Kristin</creatorcontrib><creatorcontrib>van der Aa, Niek E</creatorcontrib><creatorcontrib>Leemans, Alexander</creatorcontrib><creatorcontrib>Isgum, Ivana</creatorcontrib><creatorcontrib>Viergever, Max A</creatorcontrib><creatorcontrib>Dudink, Jeroen</creatorcontrib><creatorcontrib>de Vries, Linda S</creatorcontrib><creatorcontrib>Groenendaal, Floris</creatorcontrib><creatorcontrib>Benders, Manon J N L</creatorcontrib><title>Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organization and cerebellar volume at term-equivalent age (TEA) in extremely preterm infants. Furthermore, we aimed to evaluate the association between CBH and neurodevelopmental outcome in late infancy.
Methods
A total of 24 preterm infants with punctate CBH were included and each matched to two preterm control infants. T1-, T2-weighted images and diffusion-weighted imaging were acquired on a 3T magnetic resonance imaging (MRI) system. Regions of interest were drawn on a population-specific neonatal template and automatically registered to individual fractional anisotropy (FA) maps. Brain volumes were automatically computed. Neurodevelopmental outcome was assessed using the Bayley scales of Infant and Toddler Development at 2 years of corrected age.
Results
CBHs were not significantly related to FA in the posterior limb of the internal capsule and corpus callosum or to cerebellar volume. Infants with CBH did not have poorer neurodevelopmental outcome compared with control infants.
Conclusion
These findings suggest that the impact of mild CBH on early macroscale brain development may be limited. Future studies are needed to assess the effects of CBH on long-term neurodevelopment.</description><subject>Anisotropy</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping - methods</subject><subject>Case-Control Studies</subject><subject>Cerebellum - diagnostic imaging</subject><subject>Cerebellum - injuries</subject><subject>Child, Preschool</subject><subject>clinical-investigation</subject><subject>Cohort Studies</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurodevelopmental Disorders</subject><subject>Newborn babies</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pattern Recognition, Automated</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Premature babies</subject><subject>Risk</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU-LFDEQxYMo7uzoxQ8gAS-yMmulk0x3jrL4D1a86LlJJ5XZDN1Jm6SV9WP5CU0zq4KIp-JRP94r6hHyhMElA969nNNlA6yr4h7ZMMlhB0K098kGgLMdV6o7I-c5HwGYkJ14SM4axffQgdyQHx_8aKnBhAOOo07Uh-OSbqmNmGmIhWZ_CN55o0MZb6l2Dk058UmP9NuNL0gnXQomOnmTYi5pMWVZlzEddPDfdfExUB0sDbikaPErjnGeMJSVWYqJE9ZYqqmJoeA0x6TrBSbexFRodHROWO2nyrh6RX5EHjg9Znx8N7fk85vXn67e7a4_vn1_9ep6ZwSTZdcwa5jjci-4apS0CFrt9yAHwQcOIG1nTdOylg2tcbZVe3AWJWMKnOCsQ74lz0--c4pfFsyln3w265cCxiX3TCnoJOs6UdFnf6HHuKRQr-sbvoa1qpH_pUBAKzhvoFIXJ2p9Zk7o-jn5qX6kZ9CvfVfdr32vYkue3lkuw4T2N_qr4Aq8OAG5rsIB05_Mf9j9BDXZt4A</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Senden, Richelle E M</creator><creator>Keunen, Kristin</creator><creator>van der Aa, Niek E</creator><creator>Leemans, Alexander</creator><creator>Isgum, Ivana</creator><creator>Viergever, Max A</creator><creator>Dudink, Jeroen</creator><creator>de Vries, Linda S</creator><creator>Groenendaal, Floris</creator><creator>Benders, Manon J N L</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants</title><author>Senden, Richelle E M ; Keunen, Kristin ; van der Aa, Niek E ; Leemans, Alexander ; Isgum, Ivana ; Viergever, Max A ; Dudink, Jeroen ; de Vries, Linda S ; Groenendaal, Floris ; Benders, Manon J N L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-21dc1f356439295de0a96605b43b3005d8dc27171b7cfd7960fde51190f4318e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anisotropy</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Mapping - methods</topic><topic>Case-Control Studies</topic><topic>Cerebellum - diagnostic imaging</topic><topic>Cerebellum - injuries</topic><topic>Child, Preschool</topic><topic>clinical-investigation</topic><topic>Cohort Studies</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurodevelopmental Disorders</topic><topic>Newborn babies</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pattern Recognition, Automated</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Premature babies</topic><topic>Risk</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Senden, Richelle E M</creatorcontrib><creatorcontrib>Keunen, Kristin</creatorcontrib><creatorcontrib>van der Aa, Niek E</creatorcontrib><creatorcontrib>Leemans, Alexander</creatorcontrib><creatorcontrib>Isgum, Ivana</creatorcontrib><creatorcontrib>Viergever, Max A</creatorcontrib><creatorcontrib>Dudink, Jeroen</creatorcontrib><creatorcontrib>de Vries, Linda S</creatorcontrib><creatorcontrib>Groenendaal, Floris</creatorcontrib><creatorcontrib>Benders, Manon J N L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Senden, Richelle E M</au><au>Keunen, Kristin</au><au>van der Aa, Niek E</au><au>Leemans, Alexander</au><au>Isgum, Ivana</au><au>Viergever, Max A</au><au>Dudink, Jeroen</au><au>de Vries, Linda S</au><au>Groenendaal, Floris</au><au>Benders, Manon J N L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>83</volume><issue>5</issue><spage>1004</spage><epage>1010</epage><pages>1004-1010</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organization and cerebellar volume at term-equivalent age (TEA) in extremely preterm infants. Furthermore, we aimed to evaluate the association between CBH and neurodevelopmental outcome in late infancy.
Methods
A total of 24 preterm infants with punctate CBH were included and each matched to two preterm control infants. T1-, T2-weighted images and diffusion-weighted imaging were acquired on a 3T magnetic resonance imaging (MRI) system. Regions of interest were drawn on a population-specific neonatal template and automatically registered to individual fractional anisotropy (FA) maps. Brain volumes were automatically computed. Neurodevelopmental outcome was assessed using the Bayley scales of Infant and Toddler Development at 2 years of corrected age.
Results
CBHs were not significantly related to FA in the posterior limb of the internal capsule and corpus callosum or to cerebellar volume. Infants with CBH did not have poorer neurodevelopmental outcome compared with control infants.
Conclusion
These findings suggest that the impact of mild CBH on early macroscale brain development may be limited. Future studies are needed to assess the effects of CBH on long-term neurodevelopment.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>29360805</pmid><doi>10.1038/pr.2018.10</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anisotropy Brain - diagnostic imaging Brain Mapping - methods Case-Control Studies Cerebellum - diagnostic imaging Cerebellum - injuries Child, Preschool clinical-investigation Cohort Studies Diffusion Magnetic Resonance Imaging Female Gestational Age Humans Image Processing, Computer-Assisted - methods Infant Infant, Newborn Infant, Premature Magnetic Resonance Imaging Male Medicine Medicine & Public Health Neurodevelopmental Disorders Newborn babies NMR Nuclear magnetic resonance Pattern Recognition, Automated Pediatric Surgery Pediatrics Premature babies Risk White Matter - diagnostic imaging White Matter - pathology |
| title | Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants |
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