Pretreatment with standard‐dose intravenous methylprednisolone does not improve outcomes in newly diagnosed immune thrombocytopenia (ITP)

Objective To assess the benefits and harms to initiate corticosteroids with intravenous methylprednisolone at a conventional dose (1 mg/kg/d) to treat adults with immune thrombocytopenia (ITP). Methods Population stemmed from the prospective multicenter CARMEN registry and included newly diagnosed h...

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Veröffentlicht in:	European journal of haematology 2018-05, Vol.100 (5), p.412-418
Hauptverfasser:	Essilini, Anaïs, Comont, Thibault, Germain, Johanne, Brun, Natacha, Dingremont, Claire, Castel, Brice, Arista, Sophie, Madaule, Serge, Sailler, Laurent, Lapeyre‐Mestre, Maryse, Beyne‐Rauzy, Odile, Godeau, Bertrand, Adoue, Daniel, Moulis, Guillaume, Alric, Laurent, Balardy, Laurent, Betrian, Sarah, Borel, Cécile, Bonnet, Delphine, Brechemier, Delphine, Carreiro, Miguel, Cougoul, Pierre, Danu, Alina, Delavigne, Karen, Faurie, Thomas, Gaches, Francis, Gaspard, Marie‐Hélène, Godel‐Labouret, Aurélie, Gaudin, Clément, Giraud, Patrick, Hadj‐Khelifa, Sondess, Hebraud, Benjamin, Khatibi, Sarah, Leplay, Lorraine, Leveneur, Yann, Ollier, Sylvie, Martel, Clothilde, Martin‐Blondel, Guillaume, Michaud, Martin, Roque, Philippe, Nuccio, Fanny, Prudhomme, Laurent, Pugnet, Grégory, Recher, Christian, Remy, Véronique, Sire, Stéphane, Sommet, Agnès, Tavitian, Suzanne, Vaillant, Willy
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adult Aged Aged, 80 and over Blood Coagulation - drug effects Corticosteroids Female Humans idiopathic Idiopathic thrombocytopenic purpura Immunoglobulins, Intravenous - therapeutic use Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Intravenous administration Kaplan-Meier Estimate Male Methylprednisolone Methylprednisolone - administration & dosage Methylprednisolone - adverse effects Middle Aged Platelet Count Prednisone Prednisone - administration & dosage Premedication Prospective Studies purpura Purpura, Thrombocytopenic, Idiopathic - diagnosis Purpura, Thrombocytopenic, Idiopathic - drug therapy Thrombocytopenia thrombocytopenic Treatment Outcome
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Zusammenfassung:	Objective To assess the benefits and harms to initiate corticosteroids with intravenous methylprednisolone at a conventional dose (1 mg/kg/d) to treat adults with immune thrombocytopenia (ITP). Methods Population stemmed from the prospective multicenter CARMEN registry and included newly diagnosed hospitalized ITP adults with platelet counts
ISSN:	0902-4441 1600-0609
DOI:	10.1111/ejh.13032