Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats
Background Diabetes decreases bone strength, possibly because of cortical bone changes. Sweep imaging with Fourier transform (SWIFT) has been reported to be useful for cortical bone evaluation. Purpose To evaluate cortical bone changes in diabetic rats using SWIFT, assess the usefulness of this tech...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2018-08, Vol.48 (2), p.389-397 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Minami, Masataka Ikoma, Kazuya Horii, Motoyuki Sukenari, Tsuyoshi Onishi, Okihiro Fujiwara, Hiroyoshi Ogi, Hiroshi Itoh, Kyoko Kubo, Toshikazu |
| description | Background
Diabetes decreases bone strength, possibly because of cortical bone changes. Sweep imaging with Fourier transform (SWIFT) has been reported to be useful for cortical bone evaluation.
Purpose
To evaluate cortical bone changes in diabetic rats using SWIFT, assess the usefulness of this technique through comparisons with microcomputed tomography (μCT) and conventional MRI, and clarify the mechanism underlying cortical bone changes using histomorphometry
Study Type
Animal cohort.
Animal Model
8‐week‐old male Wistar/ST rats (N = 36) were divided into diabetes (induced by streptozotocin injection) and control groups.
Field Strength/Sequence
7.04T MRI, SWIFT.
Assessment
Six animals from each group were sacrificed at 2, 4, and 8 weeks after injection. Tibial bones were extracted and evaluated using μCT and MRI. The cortical bone mineral density (BMD) was measured using μCT. Proton density‐weighted imaging (PDWI) and SWIFT were also performed. The signal‐to‐noise ratio (SNR) was calculated for each acquisition. The bone formation rate was evaluated using histomorphometry.
Statistical Tests
Findings at each timepoint were compared using Mann–Whitney U‐tests.
Results
Cortical BMD was significantly lower in the diabetes group than in the control group only at 8 weeks (P |
| doi_str_mv | 10.1002/jmri.25955 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1990488782</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2084312474</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4415-6b0d7396d0f77e95cdc2c69aefb7d581978aa2c3f9305971d896e557c9250e8d3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMofl_8ARLwIkI1SZsmOer6taIIfuAxZNOpZmmbNWkV_71ZVz148JIJwzMvMw9CO5QcUkLY0bQN7pBxxfkSWqecsYxxWS6nP-F5RiURa2gjxikhRKmCr6I1pvKSsDJfR_YxQj00HcSIfY3v3wFmeNyaZ9c94yfXv-BzPwQHAT8E08XahxanB5-9mWYwvfPdfGzkQ--safCJ7wC7Dp86M4HUwnemj1topTZNhO3vuokez88eRpfZ9e3FeHR8ndmioDwrJ6QSuSorUgsBitvKMlsqA_VEVFxSJaQxzOa1yglXglZSlcC5sIpxArLKN9H-IncW_OsAsdetixaaxnTgh6ipUqSQUkiW0L0_6DSd2aXtNCOyyCkrRJGogwVlg48xQK1nwbUmfGhK9Fy9nqvXX-oTvPsdOUxaqH7RH9cJoAvg3TXw8U-Uvrq5Gy9CPwEbRo2V</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2084312474</pqid></control><display><type>article</type><title>Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats</title><source>Wiley Online Library - AutoHoldings Journals</source><source>Wiley Online Library Free Content</source><creator>Minami, Masataka ; Ikoma, Kazuya ; Horii, Motoyuki ; Sukenari, Tsuyoshi ; Onishi, Okihiro ; Fujiwara, Hiroyoshi ; Ogi, Hiroshi ; Itoh, Kyoko ; Kubo, Toshikazu</creator><creatorcontrib>Minami, Masataka ; Ikoma, Kazuya ; Horii, Motoyuki ; Sukenari, Tsuyoshi ; Onishi, Okihiro ; Fujiwara, Hiroyoshi ; Ogi, Hiroshi ; Itoh, Kyoko ; Kubo, Toshikazu</creatorcontrib><description>Background
Diabetes decreases bone strength, possibly because of cortical bone changes. Sweep imaging with Fourier transform (SWIFT) has been reported to be useful for cortical bone evaluation.
Purpose
To evaluate cortical bone changes in diabetic rats using SWIFT, assess the usefulness of this technique through comparisons with microcomputed tomography (μCT) and conventional MRI, and clarify the mechanism underlying cortical bone changes using histomorphometry
Study Type
Animal cohort.
Animal Model
8‐week‐old male Wistar/ST rats (N = 36) were divided into diabetes (induced by streptozotocin injection) and control groups.
Field Strength/Sequence
7.04T MRI, SWIFT.
Assessment
Six animals from each group were sacrificed at 2, 4, and 8 weeks after injection. Tibial bones were extracted and evaluated using μCT and MRI. The cortical bone mineral density (BMD) was measured using μCT. Proton density‐weighted imaging (PDWI) and SWIFT were also performed. The signal‐to‐noise ratio (SNR) was calculated for each acquisition. The bone formation rate was evaluated using histomorphometry.
Statistical Tests
Findings at each timepoint were compared using Mann–Whitney U‐tests.
Results
Cortical BMD was significantly lower in the diabetes group than in the control group only at 8 weeks (P < 0.05). At all timepoints, PDWI‐SNR showed no significant differences between groups (P = 0.59, 0.70, and 0.82 at 2, 4, and 8 weeks, respectively). SWIFT‐SNR was significantly lower in the diabetes group than in the control group (P < 0.05 at 2 and 4 weeks and P < 0.01 at 8 weeks), and the bone formation rate was significantly lower in the diabetes group than in the control group (P < 0.01 for all).
Data Conclusion
SWIFT can detect cortical bone changes even before a decline in the cortical BMD in a diabetic model.
Level of Evidence: 1
Technical Efficacy: Stage 3
J. MAGN. RESON. IMAGING 2018;48:389–397.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.25955</identifier><identifier>PMID: 29360263</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Bone growth ; Bone histomorphometry ; Bone imaging ; Bone mineral density ; bone quality ; Bone strength ; Bones ; Change detection ; Computed tomography ; Cortical bone ; Diabetes ; Diabetes mellitus ; Evaluation ; Field strength ; Fourier transforms ; Injection ; Magnetic resonance imaging ; Medical imaging ; Osteogenesis ; Osteoporosis ; Proton density (concentration) ; Rats ; Rodents ; Statistical analysis ; Statistical tests ; Streptozocin ; sweep imaging with Fourier transform</subject><ispartof>Journal of magnetic resonance imaging, 2018-08, Vol.48 (2), p.389-397</ispartof><rights>2018 International Society for Magnetic Resonance in Medicine</rights><rights>2018 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4415-6b0d7396d0f77e95cdc2c69aefb7d581978aa2c3f9305971d896e557c9250e8d3</citedby><cites>FETCH-LOGICAL-c4415-6b0d7396d0f77e95cdc2c69aefb7d581978aa2c3f9305971d896e557c9250e8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.25955$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.25955$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29360263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minami, Masataka</creatorcontrib><creatorcontrib>Ikoma, Kazuya</creatorcontrib><creatorcontrib>Horii, Motoyuki</creatorcontrib><creatorcontrib>Sukenari, Tsuyoshi</creatorcontrib><creatorcontrib>Onishi, Okihiro</creatorcontrib><creatorcontrib>Fujiwara, Hiroyoshi</creatorcontrib><creatorcontrib>Ogi, Hiroshi</creatorcontrib><creatorcontrib>Itoh, Kyoko</creatorcontrib><creatorcontrib>Kubo, Toshikazu</creatorcontrib><title>Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Diabetes decreases bone strength, possibly because of cortical bone changes. Sweep imaging with Fourier transform (SWIFT) has been reported to be useful for cortical bone evaluation.
Purpose
To evaluate cortical bone changes in diabetic rats using SWIFT, assess the usefulness of this technique through comparisons with microcomputed tomography (μCT) and conventional MRI, and clarify the mechanism underlying cortical bone changes using histomorphometry
Study Type
Animal cohort.
Animal Model
8‐week‐old male Wistar/ST rats (N = 36) were divided into diabetes (induced by streptozotocin injection) and control groups.
Field Strength/Sequence
7.04T MRI, SWIFT.
Assessment
Six animals from each group were sacrificed at 2, 4, and 8 weeks after injection. Tibial bones were extracted and evaluated using μCT and MRI. The cortical bone mineral density (BMD) was measured using μCT. Proton density‐weighted imaging (PDWI) and SWIFT were also performed. The signal‐to‐noise ratio (SNR) was calculated for each acquisition. The bone formation rate was evaluated using histomorphometry.
Statistical Tests
Findings at each timepoint were compared using Mann–Whitney U‐tests.
Results
Cortical BMD was significantly lower in the diabetes group than in the control group only at 8 weeks (P < 0.05). At all timepoints, PDWI‐SNR showed no significant differences between groups (P = 0.59, 0.70, and 0.82 at 2, 4, and 8 weeks, respectively). SWIFT‐SNR was significantly lower in the diabetes group than in the control group (P < 0.05 at 2 and 4 weeks and P < 0.01 at 8 weeks), and the bone formation rate was significantly lower in the diabetes group than in the control group (P < 0.01 for all).
Data Conclusion
SWIFT can detect cortical bone changes even before a decline in the cortical BMD in a diabetic model.
Level of Evidence: 1
Technical Efficacy: Stage 3
J. MAGN. RESON. IMAGING 2018;48:389–397.</description><subject>Bone growth</subject><subject>Bone histomorphometry</subject><subject>Bone imaging</subject><subject>Bone mineral density</subject><subject>bone quality</subject><subject>Bone strength</subject><subject>Bones</subject><subject>Change detection</subject><subject>Computed tomography</subject><subject>Cortical bone</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Evaluation</subject><subject>Field strength</subject><subject>Fourier transforms</subject><subject>Injection</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Osteogenesis</subject><subject>Osteoporosis</subject><subject>Proton density (concentration)</subject><subject>Rats</subject><subject>Rodents</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Streptozocin</subject><subject>sweep imaging with Fourier transform</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMofl_8ARLwIkI1SZsmOer6taIIfuAxZNOpZmmbNWkV_71ZVz148JIJwzMvMw9CO5QcUkLY0bQN7pBxxfkSWqecsYxxWS6nP-F5RiURa2gjxikhRKmCr6I1pvKSsDJfR_YxQj00HcSIfY3v3wFmeNyaZ9c94yfXv-BzPwQHAT8E08XahxanB5-9mWYwvfPdfGzkQ--safCJ7wC7Dp86M4HUwnemj1topTZNhO3vuokez88eRpfZ9e3FeHR8ndmioDwrJ6QSuSorUgsBitvKMlsqA_VEVFxSJaQxzOa1yglXglZSlcC5sIpxArLKN9H-IncW_OsAsdetixaaxnTgh6ipUqSQUkiW0L0_6DSd2aXtNCOyyCkrRJGogwVlg48xQK1nwbUmfGhK9Fy9nqvXX-oTvPsdOUxaqH7RH9cJoAvg3TXw8U-Uvrq5Gy9CPwEbRo2V</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Minami, Masataka</creator><creator>Ikoma, Kazuya</creator><creator>Horii, Motoyuki</creator><creator>Sukenari, Tsuyoshi</creator><creator>Onishi, Okihiro</creator><creator>Fujiwara, Hiroyoshi</creator><creator>Ogi, Hiroshi</creator><creator>Itoh, Kyoko</creator><creator>Kubo, Toshikazu</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201808</creationdate><title>Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats</title><author>Minami, Masataka ; Ikoma, Kazuya ; Horii, Motoyuki ; Sukenari, Tsuyoshi ; Onishi, Okihiro ; Fujiwara, Hiroyoshi ; Ogi, Hiroshi ; Itoh, Kyoko ; Kubo, Toshikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4415-6b0d7396d0f77e95cdc2c69aefb7d581978aa2c3f9305971d896e557c9250e8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bone growth</topic><topic>Bone histomorphometry</topic><topic>Bone imaging</topic><topic>Bone mineral density</topic><topic>bone quality</topic><topic>Bone strength</topic><topic>Bones</topic><topic>Change detection</topic><topic>Computed tomography</topic><topic>Cortical bone</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Evaluation</topic><topic>Field strength</topic><topic>Fourier transforms</topic><topic>Injection</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Osteogenesis</topic><topic>Osteoporosis</topic><topic>Proton density (concentration)</topic><topic>Rats</topic><topic>Rodents</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Streptozocin</topic><topic>sweep imaging with Fourier transform</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minami, Masataka</creatorcontrib><creatorcontrib>Ikoma, Kazuya</creatorcontrib><creatorcontrib>Horii, Motoyuki</creatorcontrib><creatorcontrib>Sukenari, Tsuyoshi</creatorcontrib><creatorcontrib>Onishi, Okihiro</creatorcontrib><creatorcontrib>Fujiwara, Hiroyoshi</creatorcontrib><creatorcontrib>Ogi, Hiroshi</creatorcontrib><creatorcontrib>Itoh, Kyoko</creatorcontrib><creatorcontrib>Kubo, Toshikazu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minami, Masataka</au><au>Ikoma, Kazuya</au><au>Horii, Motoyuki</au><au>Sukenari, Tsuyoshi</au><au>Onishi, Okihiro</au><au>Fujiwara, Hiroyoshi</au><au>Ogi, Hiroshi</au><au>Itoh, Kyoko</au><au>Kubo, Toshikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2018-08</date><risdate>2018</risdate><volume>48</volume><issue>2</issue><spage>389</spage><epage>397</epage><pages>389-397</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Diabetes decreases bone strength, possibly because of cortical bone changes. Sweep imaging with Fourier transform (SWIFT) has been reported to be useful for cortical bone evaluation.
Purpose
To evaluate cortical bone changes in diabetic rats using SWIFT, assess the usefulness of this technique through comparisons with microcomputed tomography (μCT) and conventional MRI, and clarify the mechanism underlying cortical bone changes using histomorphometry
Study Type
Animal cohort.
Animal Model
8‐week‐old male Wistar/ST rats (N = 36) were divided into diabetes (induced by streptozotocin injection) and control groups.
Field Strength/Sequence
7.04T MRI, SWIFT.
Assessment
Six animals from each group were sacrificed at 2, 4, and 8 weeks after injection. Tibial bones were extracted and evaluated using μCT and MRI. The cortical bone mineral density (BMD) was measured using μCT. Proton density‐weighted imaging (PDWI) and SWIFT were also performed. The signal‐to‐noise ratio (SNR) was calculated for each acquisition. The bone formation rate was evaluated using histomorphometry.
Statistical Tests
Findings at each timepoint were compared using Mann–Whitney U‐tests.
Results
Cortical BMD was significantly lower in the diabetes group than in the control group only at 8 weeks (P < 0.05). At all timepoints, PDWI‐SNR showed no significant differences between groups (P = 0.59, 0.70, and 0.82 at 2, 4, and 8 weeks, respectively). SWIFT‐SNR was significantly lower in the diabetes group than in the control group (P < 0.05 at 2 and 4 weeks and P < 0.01 at 8 weeks), and the bone formation rate was significantly lower in the diabetes group than in the control group (P < 0.01 for all).
Data Conclusion
SWIFT can detect cortical bone changes even before a decline in the cortical BMD in a diabetic model.
Level of Evidence: 1
Technical Efficacy: Stage 3
J. MAGN. RESON. IMAGING 2018;48:389–397.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29360263</pmid><doi>10.1002/jmri.25955</doi><tpages>9</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; Wiley Online Library Free Content |
| subjects | Bone growth Bone histomorphometry Bone imaging Bone mineral density bone quality Bone strength Bones Change detection Computed tomography Cortical bone Diabetes Diabetes mellitus Evaluation Field strength Fourier transforms Injection Magnetic resonance imaging Medical imaging Osteogenesis Osteoporosis Proton density (concentration) Rats Rodents Statistical analysis Statistical tests Streptozocin sweep imaging with Fourier transform |
| title | Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats |
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