Fatty acid transport receptor soluble CD36 and dietary fatty acid pattern in type 2 diabetic patients: a comparative study
Recently, it has been remarked that dietary fatty acids and fatty acid receptors might be involved in the aetiology of diabetes. Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistanc...
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| Veröffentlicht in: | British journal of nutrition 2018-01, Vol.119 (2), p.153-162 |
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| creator | Ekici, Merve Kisa, Ucler Arikan Durmaz, Senay Ugur, Elif Nergiz-Unal, Reyhan |
| description | Recently, it has been remarked that dietary fatty acids and fatty acid receptors might be involved in the aetiology of diabetes. Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistance in type 2 diabetes mellitus (DM). The study was carried out with thirty-eight newly diagnosed type 2 DM patients and thirty-seven healthy volunteers, aged 30–65 years. In the study, socio-demographic characteristics, dietary fat type and fatty acid pattern of individuals were recorded. After anthropometric measurements were taken, blood CD36, glucose, TAG and insulin levels were analysed. The results showed that although the type of fatty acid intake did not differ between the groups (P>0·05), the consumption of olive oil in the type 2 DM group was lower than the control group (P |
| doi_str_mv | 10.1017/S0007114517003269 |
| format | Article |
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Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistance in type 2 diabetes mellitus (DM). The study was carried out with thirty-eight newly diagnosed type 2 DM patients and thirty-seven healthy volunteers, aged 30–65 years. In the study, socio-demographic characteristics, dietary fat type and fatty acid pattern of individuals were recorded. After anthropometric measurements were taken, blood CD36, glucose, TAG and insulin levels were analysed. The results showed that although the type of fatty acid intake did not differ between the groups (P>0·05), the consumption of olive oil in the type 2 DM group was lower than the control group (P<0·05). Mean blood glucose, insulin, insulin resistance, TAG and sCD36 levels were determined to be higher in the type 2 DM group (P<0·05). However, there was no correlation between sCD36 levels and homeostatic model assessment of insulin resistance (HOMA-IR) value, blood insulin and TAG levels, waist circumference, dietary fatty acid pattern and food preferences in the type 2 DM group (P>0·05). Crucially, elevated sCD36 levels increased the type 2 DM risk (OR 1·21, P<0·05). In conclusion, sCD36 level may be a possible biomarker, independent from the dietary fatty acid pattern, for type 2 DM owing to its higher levels in these patients. Therefore, the new insights make CD36 attractive as a therapeutic target for diabetes.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114517003269</identifier><identifier>PMID: 29359682</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Anthropometry ; Biomarkers ; Blood ; Blood glucose ; Body mass index ; CD36 antigen ; Comparative studies ; Demographics ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diet ; Endocrinology ; Fasting ; Fatty acids ; Food ; Food preferences ; Glucose ; Health sciences ; Insulin ; Insulin resistance ; Metabolism ; Nutrition research ; Nutritional Endocrinology ; Oils & fats ; Olive oil ; Patients ; Receptors</subject><ispartof>British journal of nutrition, 2018-01, Vol.119 (2), p.153-162</ispartof><rights>Copyright © The Authors 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-187412c86d7a0d0437dc80ea8c9f1f60fe2b5ed48c90ab91b63835d03bf5e1183</citedby><cites>FETCH-LOGICAL-c416t-187412c86d7a0d0437dc80ea8c9f1f60fe2b5ed48c90ab91b63835d03bf5e1183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114517003269/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29359682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ekici, Merve</creatorcontrib><creatorcontrib>Kisa, Ucler</creatorcontrib><creatorcontrib>Arikan Durmaz, Senay</creatorcontrib><creatorcontrib>Ugur, Elif</creatorcontrib><creatorcontrib>Nergiz-Unal, Reyhan</creatorcontrib><title>Fatty acid transport receptor soluble CD36 and dietary fatty acid pattern in type 2 diabetic patients: a comparative study</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Recently, it has been remarked that dietary fatty acids and fatty acid receptors might be involved in the aetiology of diabetes. Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistance in type 2 diabetes mellitus (DM). The study was carried out with thirty-eight newly diagnosed type 2 DM patients and thirty-seven healthy volunteers, aged 30–65 years. In the study, socio-demographic characteristics, dietary fat type and fatty acid pattern of individuals were recorded. After anthropometric measurements were taken, blood CD36, glucose, TAG and insulin levels were analysed. The results showed that although the type of fatty acid intake did not differ between the groups (P>0·05), the consumption of olive oil in the type 2 DM group was lower than the control group (P<0·05). Mean blood glucose, insulin, insulin resistance, TAG and sCD36 levels were determined to be higher in the type 2 DM group (P<0·05). However, there was no correlation between sCD36 levels and homeostatic model assessment of insulin resistance (HOMA-IR) value, blood insulin and TAG levels, waist circumference, dietary fatty acid pattern and food preferences in the type 2 DM group (P>0·05). Crucially, elevated sCD36 levels increased the type 2 DM risk (OR 1·21, P<0·05). In conclusion, sCD36 level may be a possible biomarker, independent from the dietary fatty acid pattern, for type 2 DM owing to its higher levels in these patients. Therefore, the new insights make CD36 attractive as a therapeutic target for diabetes.</description><subject>Anthropometry</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Body mass index</subject><subject>CD36 antigen</subject><subject>Comparative studies</subject><subject>Demographics</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diet</subject><subject>Endocrinology</subject><subject>Fasting</subject><subject>Fatty acids</subject><subject>Food</subject><subject>Food preferences</subject><subject>Glucose</subject><subject>Health sciences</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Nutritional Endocrinology</subject><subject>Oils & fats</subject><subject>Olive oil</subject><subject>Patients</subject><subject>Receptors</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUtP3DAUhS3UCoZpf0A3yFI33YT6xokf7KppB5CQWADryLFvUEZ5YTuVpr--Hs1QEBUr-_p859jyIeQLsHNgIL_fMcYkQFGCZIznQh-RBRSyzHIh8g9ksZOznX5CTkPYpFEB08fkJNe81ELlC_JnbWLcUmNbR6M3Q5hGH6lHi1McPQ1jN9cd0tVPLqgZHHUtRuO3tHmxTWmLfqDtQON2QponyNQYW7uTWhxiuKCG2rGfjE8Hv5GGOLvtJ_KxMV3Az4d1SR7Wv-5XV9nN7eX16sdNZgsQMQMlC8itEk4a5ljBpbOKoVFWN9AI1mBel-iKNDNTa6gFV7x0jNdNiQCKL8m3fe7kx6cZQ6z6NljsOjPgOIcKtGaFElJBQr--QTfj7If0ukQprUqpuUwU7CnrxxA8NtXk2z79SgWs2hVT_VdM8pwdkue6R_fP8dxEAvgh1PS1b90jvrr73di_8MCXeQ</recordid><startdate>20180128</startdate><enddate>20180128</enddate><creator>Ekici, Merve</creator><creator>Kisa, Ucler</creator><creator>Arikan Durmaz, Senay</creator><creator>Ugur, Elif</creator><creator>Nergiz-Unal, Reyhan</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180128</creationdate><title>Fatty acid transport receptor soluble CD36 and dietary fatty acid pattern in type 2 diabetic patients: a comparative study</title><author>Ekici, Merve ; Kisa, Ucler ; Arikan Durmaz, Senay ; Ugur, Elif ; Nergiz-Unal, Reyhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-187412c86d7a0d0437dc80ea8c9f1f60fe2b5ed48c90ab91b63835d03bf5e1183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anthropometry</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Blood glucose</topic><topic>Body mass index</topic><topic>CD36 antigen</topic><topic>Comparative studies</topic><topic>Demographics</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diet</topic><topic>Endocrinology</topic><topic>Fasting</topic><topic>Fatty acids</topic><topic>Food</topic><topic>Food preferences</topic><topic>Glucose</topic><topic>Health sciences</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>Nutritional Endocrinology</topic><topic>Oils & fats</topic><topic>Olive oil</topic><topic>Patients</topic><topic>Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ekici, Merve</creatorcontrib><creatorcontrib>Kisa, Ucler</creatorcontrib><creatorcontrib>Arikan Durmaz, Senay</creatorcontrib><creatorcontrib>Ugur, Elif</creatorcontrib><creatorcontrib>Nergiz-Unal, Reyhan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ekici, Merve</au><au>Kisa, Ucler</au><au>Arikan Durmaz, Senay</au><au>Ugur, Elif</au><au>Nergiz-Unal, Reyhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty acid transport receptor soluble CD36 and dietary fatty acid pattern in type 2 diabetic patients: a comparative study</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2018-01-28</date><risdate>2018</risdate><volume>119</volume><issue>2</issue><spage>153</spage><epage>162</epage><pages>153-162</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Recently, it has been remarked that dietary fatty acids and fatty acid receptors might be involved in the aetiology of diabetes. Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistance in type 2 diabetes mellitus (DM). The study was carried out with thirty-eight newly diagnosed type 2 DM patients and thirty-seven healthy volunteers, aged 30–65 years. In the study, socio-demographic characteristics, dietary fat type and fatty acid pattern of individuals were recorded. After anthropometric measurements were taken, blood CD36, glucose, TAG and insulin levels were analysed. The results showed that although the type of fatty acid intake did not differ between the groups (P>0·05), the consumption of olive oil in the type 2 DM group was lower than the control group (P<0·05). Mean blood glucose, insulin, insulin resistance, TAG and sCD36 levels were determined to be higher in the type 2 DM group (P<0·05). However, there was no correlation between sCD36 levels and homeostatic model assessment of insulin resistance (HOMA-IR) value, blood insulin and TAG levels, waist circumference, dietary fatty acid pattern and food preferences in the type 2 DM group (P>0·05). Crucially, elevated sCD36 levels increased the type 2 DM risk (OR 1·21, P<0·05). In conclusion, sCD36 level may be a possible biomarker, independent from the dietary fatty acid pattern, for type 2 DM owing to its higher levels in these patients. Therefore, the new insights make CD36 attractive as a therapeutic target for diabetes.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>29359682</pmid><doi>10.1017/S0007114517003269</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anthropometry Biomarkers Blood Blood glucose Body mass index CD36 antigen Comparative studies Demographics Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Endocrinology Fasting Fatty acids Food Food preferences Glucose Health sciences Insulin Insulin resistance Metabolism Nutrition research Nutritional Endocrinology Oils & fats Olive oil Patients Receptors |
| title | Fatty acid transport receptor soluble CD36 and dietary fatty acid pattern in type 2 diabetic patients: a comparative study |
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