Linoleic Acid:Dihomo-γ-Linolenic Acid Ratio Predicts the Efficacy of Zn-Biofortified Wheat in Chicken (Gallus gallus)
The amount of Zn absorbed from Zn-biofortified wheat material has been determined using an in vivo model of Zn absorption. The erythrocyte linoleic:dihomo -γ-linolenic acid (LA:DGLA) ratio was used as a biomarker of Zn status. Two groups of chickens (n = 15) were fed different diets: a high-Zn (46.5...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2018-02, Vol.66 (6), p.1394-1400 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Knez, Marija Tako, Elad Glahn, Raymond P Kolba, Nikolai de Courcy-Ireland, Emma Stangoulis, James C. R |
| description | The amount of Zn absorbed from Zn-biofortified wheat material has been determined using an in vivo model of Zn absorption. The erythrocyte linoleic:dihomo -γ-linolenic acid (LA:DGLA) ratio was used as a biomarker of Zn status. Two groups of chickens (n = 15) were fed different diets: a high-Zn (46.5 μg Zn g–1) and a low-Zn wheat-based diet (32.8 μg Zn g–1). Dietary Zn intakes, body weight, serum Zn, and the erythrocyte fatty acid profile were measured, and tissues were taken for gene expression analysis. Serum Zn concentrations were greater in the high Zn group (p < 0.05). Duodenal mRNA expression of various Zn transporters demonstrated expression upregulation in the birds fed a low Zn diet (n = 15, p < 0.05). The LA:DGLA ratio was higher in the birds fed the low Zn diet (p < 0.05). The higher amount of Zn in the biofortified wheat resulted in a greater Zn uptake. |
| doi_str_mv | 10.1021/acs.jafc.7b04905 |
| format | Article |
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The higher amount of Zn in the biofortified wheat resulted in a greater Zn uptake.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.7b04905</identifier><identifier>PMID: 29359556</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>8,11,14-Eicosatrienoic Acid - analysis ; 8,11,14-Eicosatrienoic Acid - metabolism ; Animal Feed - analysis ; Animals ; Biofortification ; Chickens - genetics ; Chickens - growth & development ; Chickens - metabolism ; Fatty Acids - analysis ; Fatty Acids - metabolism ; Female ; Linoleic Acid - analysis ; Linoleic Acid - metabolism ; Male ; Triticum - chemistry ; Triticum - metabolism ; Zinc - analysis ; Zinc - metabolism</subject><ispartof>Journal of agricultural and food chemistry, 2018-02, Vol.66 (6), p.1394-1400</ispartof><rights>Copyright © 2018 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a336t-2bdb327760dfb455712b928034418549aae2dcf24e1429ab57f358d325fcc1973</citedby><cites>FETCH-LOGICAL-a336t-2bdb327760dfb455712b928034418549aae2dcf24e1429ab57f358d325fcc1973</cites><orcidid>0000-0003-2773-0137</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.7b04905$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.7b04905$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29359556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knez, Marija</creatorcontrib><creatorcontrib>Tako, Elad</creatorcontrib><creatorcontrib>Glahn, Raymond P</creatorcontrib><creatorcontrib>Kolba, Nikolai</creatorcontrib><creatorcontrib>de Courcy-Ireland, Emma</creatorcontrib><creatorcontrib>Stangoulis, James C. R</creatorcontrib><title>Linoleic Acid:Dihomo-γ-Linolenic Acid Ratio Predicts the Efficacy of Zn-Biofortified Wheat in Chicken (Gallus gallus)</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>The amount of Zn absorbed from Zn-biofortified wheat material has been determined using an in vivo model of Zn absorption. The erythrocyte linoleic:dihomo -γ-linolenic acid (LA:DGLA) ratio was used as a biomarker of Zn status. Two groups of chickens (n = 15) were fed different diets: a high-Zn (46.5 μg Zn g–1) and a low-Zn wheat-based diet (32.8 μg Zn g–1). Dietary Zn intakes, body weight, serum Zn, and the erythrocyte fatty acid profile were measured, and tissues were taken for gene expression analysis. Serum Zn concentrations were greater in the high Zn group (p < 0.05). Duodenal mRNA expression of various Zn transporters demonstrated expression upregulation in the birds fed a low Zn diet (n = 15, p < 0.05). The LA:DGLA ratio was higher in the birds fed the low Zn diet (p < 0.05). The higher amount of Zn in the biofortified wheat resulted in a greater Zn uptake.</description><subject>8,11,14-Eicosatrienoic Acid - analysis</subject><subject>8,11,14-Eicosatrienoic Acid - metabolism</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Biofortification</subject><subject>Chickens - genetics</subject><subject>Chickens - growth & development</subject><subject>Chickens - metabolism</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids - metabolism</subject><subject>Female</subject><subject>Linoleic Acid - analysis</subject><subject>Linoleic Acid - metabolism</subject><subject>Male</subject><subject>Triticum - chemistry</subject><subject>Triticum - metabolism</subject><subject>Zinc - analysis</subject><subject>Zinc - metabolism</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Kw0AURgdRbK3uXcksFUydn0yScVdrrUJBEUVwEyaTGTM1ydRMIvS5fA-fybSJ7lxduPd8H9wDwDFGY4wIvhDSjZdCy3GYIJ8jtgOGmBHkMYyjXTBELeNFLMADcODcEiEUsRDtgwHhlHHGgiH4XJjS5spIOJEmvbw2mS2s9_3ldfuyP8BHURsLHyqVGlk7WGcKzrQ2Usg1tBq-lt6VsdpWtdFGpfAlU6KGpoTTzMh3VcLTucjzxsG37Tg7BHta5E4d9XMEnm9mT9Nbb3E_v5tOFp6gNKg9kqQJJWEYoFQnPmMhJgknEaK-jyPmcyEUSaUmvsI-4SJhoaYsSilhWkrMQzoCp13vqrIfjXJ1XBgnVZ6LUtnGxZhz5EdByGiLog6VlXWuUjpeVaYQ1TrGKN7Yjlvb8cZ23NtuIyd9e5MUKv0L_OptgfMO2EZtU5Xts__3_QDAjIse</recordid><startdate>20180214</startdate><enddate>20180214</enddate><creator>Knez, Marija</creator><creator>Tako, Elad</creator><creator>Glahn, Raymond P</creator><creator>Kolba, Nikolai</creator><creator>de Courcy-Ireland, Emma</creator><creator>Stangoulis, James C. 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R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-2bdb327760dfb455712b928034418549aae2dcf24e1429ab57f358d325fcc1973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>8,11,14-Eicosatrienoic Acid - analysis</topic><topic>8,11,14-Eicosatrienoic Acid - metabolism</topic><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Biofortification</topic><topic>Chickens - genetics</topic><topic>Chickens - growth & development</topic><topic>Chickens - metabolism</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids - metabolism</topic><topic>Female</topic><topic>Linoleic Acid - analysis</topic><topic>Linoleic Acid - metabolism</topic><topic>Male</topic><topic>Triticum - chemistry</topic><topic>Triticum - metabolism</topic><topic>Zinc - analysis</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knez, Marija</creatorcontrib><creatorcontrib>Tako, Elad</creatorcontrib><creatorcontrib>Glahn, Raymond P</creatorcontrib><creatorcontrib>Kolba, Nikolai</creatorcontrib><creatorcontrib>de Courcy-Ireland, Emma</creatorcontrib><creatorcontrib>Stangoulis, James C. 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Food Chem</addtitle><date>2018-02-14</date><risdate>2018</risdate><volume>66</volume><issue>6</issue><spage>1394</spage><epage>1400</epage><pages>1394-1400</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>The amount of Zn absorbed from Zn-biofortified wheat material has been determined using an in vivo model of Zn absorption. The erythrocyte linoleic:dihomo -γ-linolenic acid (LA:DGLA) ratio was used as a biomarker of Zn status. Two groups of chickens (n = 15) were fed different diets: a high-Zn (46.5 μg Zn g–1) and a low-Zn wheat-based diet (32.8 μg Zn g–1). Dietary Zn intakes, body weight, serum Zn, and the erythrocyte fatty acid profile were measured, and tissues were taken for gene expression analysis. Serum Zn concentrations were greater in the high Zn group (p < 0.05). Duodenal mRNA expression of various Zn transporters demonstrated expression upregulation in the birds fed a low Zn diet (n = 15, p < 0.05). The LA:DGLA ratio was higher in the birds fed the low Zn diet (p < 0.05). The higher amount of Zn in the biofortified wheat resulted in a greater Zn uptake.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>29359556</pmid><doi>10.1021/acs.jafc.7b04905</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2773-0137</orcidid></addata></record> |
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| subjects | 8,11,14-Eicosatrienoic Acid - analysis 8,11,14-Eicosatrienoic Acid - metabolism Animal Feed - analysis Animals Biofortification Chickens - genetics Chickens - growth & development Chickens - metabolism Fatty Acids - analysis Fatty Acids - metabolism Female Linoleic Acid - analysis Linoleic Acid - metabolism Male Triticum - chemistry Triticum - metabolism Zinc - analysis Zinc - metabolism |
| title | Linoleic Acid:Dihomo-γ-Linolenic Acid Ratio Predicts the Efficacy of Zn-Biofortified Wheat in Chicken (Gallus gallus) |
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