A cluster of donor‐derived Cryptococcus neoformans infection affecting lung, liver, and kidney transplant recipients: Case report and review of literature
Donor‐derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor‐derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kid...
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| Veröffentlicht in: | Transplant infectious disease 2018-04, Vol.20 (2), p.e12836-n/a |
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| creator | Camargo, Jose F. Simkins, Jacques Schain, Denise C. Gonzalez, A. Adrian Alcaide, Maria L. Anjan, Shweta Guerra, Giselle Roth, David Kupin, Warren L. Mattiazzi, Adela Tan, Yaohong Milikowski, Clara Morris, Michele I. Abbo, Lilian M. |
| description | Donor‐derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor‐derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8‐12 weeks after transplantation, which is beyond the incubation period previously reported for donor‐derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post‐transplant. Communication between reference laboratories, transplant centers, and organ procurement organizations is critical to improve outcomes. |
| doi_str_mv | 10.1111/tid.12836 |
| format | Article |
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Adrian ; Alcaide, Maria L. ; Anjan, Shweta ; Guerra, Giselle ; Roth, David ; Kupin, Warren L. ; Mattiazzi, Adela ; Tan, Yaohong ; Milikowski, Clara ; Morris, Michele I. ; Abbo, Lilian M.</creator><creatorcontrib>Camargo, Jose F. ; Simkins, Jacques ; Schain, Denise C. ; Gonzalez, A. Adrian ; Alcaide, Maria L. ; Anjan, Shweta ; Guerra, Giselle ; Roth, David ; Kupin, Warren L. ; Mattiazzi, Adela ; Tan, Yaohong ; Milikowski, Clara ; Morris, Michele I. ; Abbo, Lilian M.</creatorcontrib><description>Donor‐derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor‐derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8‐12 weeks after transplantation, which is beyond the incubation period previously reported for donor‐derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post‐transplant. Communication between reference laboratories, transplant centers, and organ procurement organizations is critical to improve outcomes.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.12836</identifier><identifier>PMID: 29359837</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Case reports ; Clusters ; Cryptococcosis ; Cryptococcosis - microbiology ; Cryptococcus ; Cryptococcus neoformans ; Differential diagnosis ; donor‐derived infection ; Female ; Fungal infections ; Humans ; Kidney transplantation ; Kidney transplants ; Literature reviews ; Liver ; Liver transplantation ; Lung transplantation ; Male ; Organ Transplantation - adverse effects ; solid organ transplant ; Tissue Donors ; Transplant Recipients ; Transplantation ; Transplants & implants</subject><ispartof>Transplant infectious disease, 2018-04, Vol.20 (2), p.e12836-n/a</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons A/S. 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Here we present a cluster of proven donor‐derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8‐12 weeks after transplantation, which is beyond the incubation period previously reported for donor‐derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post‐transplant. Communication between reference laboratories, transplant centers, and organ procurement organizations is critical to improve outcomes.</description><subject>Adult</subject><subject>Aged</subject><subject>Case reports</subject><subject>Clusters</subject><subject>Cryptococcosis</subject><subject>Cryptococcosis - microbiology</subject><subject>Cryptococcus</subject><subject>Cryptococcus neoformans</subject><subject>Differential diagnosis</subject><subject>donor‐derived infection</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>Kidney transplantation</subject><subject>Kidney transplants</subject><subject>Literature reviews</subject><subject>Liver</subject><subject>Liver transplantation</subject><subject>Lung transplantation</subject><subject>Male</subject><subject>Organ Transplantation - adverse effects</subject><subject>solid organ transplant</subject><subject>Tissue Donors</subject><subject>Transplant Recipients</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtOHDEQhq0oKDySRS6ALGWTBQ1-9HTb7NCEl4TEZvZWt11GJj12Y7tBs8sROACny0nwNJBFvPGvqq9Kv-pH6Dslx7S8k-zMMWWCN5_QHuVSVpw07POsRcVYy3fRfkr3hNBW1vIL2mWSL6Tg7R56OcN6mFKGiIPFJvgQ__55NhDdIxi8jJsxBx20nhL2EGyI684n7LwFnV3wuLOz8nd4mPzdER7KXDzCnTf4tzMeNjjHMjEOnc84gnajA5_TKV52CUphDDHPdIRHB09bE4Mrbro8RfiKdmw3JPj2_h-g1cX5anlV3dxeXi_PbqqRtbKpqIC-XYiWkd5wJohkQrRG695YaqUxddtby3rBgfc9B9Zoyzhhda35FuIH6Ofb2jGGhwlSVmuXNAzFM4QpKSolqcVCNqSgP_5D78MUfTGnGClL65oQWajDd2rq12DUGN26ixv1cfYCnLwBT26Azb8-JWqbpyp5qjlPtbr-NQv-Crpwlpo</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Camargo, Jose F.</creator><creator>Simkins, Jacques</creator><creator>Schain, Denise C.</creator><creator>Gonzalez, A. 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| ispartof | Transplant infectious disease, 2018-04, Vol.20 (2), p.e12836-n/a |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Case reports Clusters Cryptococcosis Cryptococcosis - microbiology Cryptococcus Cryptococcus neoformans Differential diagnosis donor‐derived infection Female Fungal infections Humans Kidney transplantation Kidney transplants Literature reviews Liver Liver transplantation Lung transplantation Male Organ Transplantation - adverse effects solid organ transplant Tissue Donors Transplant Recipients Transplantation Transplants & implants |
| title | A cluster of donor‐derived Cryptococcus neoformans infection affecting lung, liver, and kidney transplant recipients: Case report and review of literature |
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