An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp 3 )-H functionalization
A Mn-promoted intermolecular oxidative radical heteroannulation of N-(2-cyanoaryl)-acrylamides and tertiary silanes has been described, which provides an efficient route to produce silicon/nitrogen heterocycles, sila-analogues of the known carbon-based structural motifs prevalent in bioactive natura...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2018, Vol.54 (11), p.1367-1370 |
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| container_issue | 11 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Wu, Li-Jun Yang, Yuan Song, Ren-Jie Yu, Jiang-Xi Li, Jin-Heng He, De-Liang |
| description | A Mn-promoted intermolecular oxidative radical heteroannulation of N-(2-cyanoaryl)-acrylamides and tertiary silanes has been described, which provides an efficient route to produce silicon/nitrogen heterocycles, sila-analogues of the known carbon-based structural motifs prevalent in bioactive natural products, pharmaceuticals and materials. The reaction enables Si-incorporation by controlling accurately several chemical bond cleavage and formation processes. Moreover, this reaction represents a new one-step construction of 1,3-azasiline-fused quinolinones that was achieved via silyl C(sp
)-H functionalization using an oxidative radical strategy. |
| doi_str_mv | 10.1039/c7cc08996a |
| format | Article |
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| ispartof | Chemical communications (Cambridge, England), 2018, Vol.54 (11), p.1367-1370 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Chemical reactions Natural products Nitrogen Organic chemistry Silanes Silicon |
| title | An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp 3 )-H functionalization |
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