Post-translational modifications in tumor biomarkers: the next challenge for aptamers?

Advances in proteomics have fueled the search for novel cancer biomarkers with higher selectivity. Differential expression of low abundant proteins has been the usual way of finding those biomarkers. The existence of a selective receptor for each biomarker is compulsory for their use in diagnostic/p...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2018-03, Vol.410 (8), p.2059-2065
Hauptverfasser:	Díaz-Fernández, Ana, Miranda-Castro, Rebeca, de-los-Santos-Álvarez, Noemí, Lobo-Castañón, María Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Analytical Chemistry Animals Antibodies Aptamers Aptamers, Nucleotide - analysis Aptamers, Nucleotide - metabolism Biochemistry Biological markers Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Biosensing Techniques - methods Cancer Carbohydrates Characterization and Evaluation of Materials Chemical synthesis Chemistry Chemistry and Materials Science Diagnostic software Diagnostic systems Feature Article Food Science Genetic aspects Glycoproteins Glycosylation Health aspects Humans Laboratory Medicine Lectins Low level Models, Molecular Monitoring/Environmental Analysis Neoplasms - diagnosis Neoplasms - metabolism Polysaccharides - analysis Polysaccharides - metabolism Post-translation Post-translational modifications Protein Processing, Post-Translational Proteins Proteomics Receptors Selectivity SELEX Aptamer Technique - methods Translation Tumors
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