Stable isotope compounds - production, detection, and application
Stable isotopes are used in wide fields of application from natural tracers in biology, geology and archeology through studies of metabolic fluxes to their application as tracers in quantitative proteomics and structural biology. We review the use of stable isotopes of biogenic elements (H, C, N, O,...
Gespeichert in:
| Veröffentlicht in: | Biotechnology advances 2018-05, Vol.36 (3), p.784-797 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 797 |
|---|---|
| container_issue | 3 |
| container_start_page | 784 |
| container_title | Biotechnology advances |
| container_volume | 36 |
| creator | Zachleder, Vilém Vítová, Milada Hlavová, Monika Moudříková, Šárka Mojzeš, Peter Heumann, Hermann Becher, Johannes R. Bišová, Kateřina |
| description | Stable isotopes are used in wide fields of application from natural tracers in biology, geology and archeology through studies of metabolic fluxes to their application as tracers in quantitative proteomics and structural biology. We review the use of stable isotopes of biogenic elements (H, C, N, O, S, Mg, Se) with the emphasis on hydrogen and its heavy isotope deuterium. We will discuss the limitations of enriching various compounds in stable isotopes when produced in living organisms. Finally, we overview methods for measuring stable isotopes, focusing on methods for detection in single cells in situ and their exploitation in modern biotechnologies. |
| doi_str_mv | 10.1016/j.biotechadv.2018.01.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1989914265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0734975018300107</els_id><sourcerecordid>1989914265</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-169bac82280d8e0df5cf2b95be1074b304c184e875201d206e6900b2db2ff8573</originalsourceid><addsrcrecordid>eNqFkEtLxDAQx4Mo7vr4ClLw4sGuk7Rpk-MqvkDwoJ5DHlPM0m1q0wp-e7OsD_AiDCSE3-Q_8yMko7CgQKuL1cL4MKJ91e59wYCKBdBUsEPmVNRFToWUu2QOdVHmsuYwIwcxrgAoB17skxmTBedcyjlZPo3atJj5GMbQY2bDug9T52KWZ_0Q3GRHH7rzzGGK21515zLd9623evNwRPYa3UY8_joPycvN9fPVXf7weHt_tXzIbVnIMaeVNNoKxgQ4geAabhtmJDdIoS5NAaWlokRR87SPY1BhJQEMc4Y1jeB1cUjOtv-msd4mjKNa-2ixbXWHYYqKyrQ0LVnFE3r6B12FaejSdIpBXRVVLeWGElvKDiHGARvVD36thw9FQW00q5X61aw2mhXQVJBaT74CJrNG99P47TUBl1sAk5F3j4OK1mNn0fkheVQu-P9TPgGfOZHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2076367995</pqid></control><display><type>article</type><title>Stable isotope compounds - production, detection, and application</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Zachleder, Vilém ; Vítová, Milada ; Hlavová, Monika ; Moudříková, Šárka ; Mojzeš, Peter ; Heumann, Hermann ; Becher, Johannes R. ; Bišová, Kateřina</creator><creatorcontrib>Zachleder, Vilém ; Vítová, Milada ; Hlavová, Monika ; Moudříková, Šárka ; Mojzeš, Peter ; Heumann, Hermann ; Becher, Johannes R. ; Bišová, Kateřina</creatorcontrib><description>Stable isotopes are used in wide fields of application from natural tracers in biology, geology and archeology through studies of metabolic fluxes to their application as tracers in quantitative proteomics and structural biology. We review the use of stable isotopes of biogenic elements (H, C, N, O, S, Mg, Se) with the emphasis on hydrogen and its heavy isotope deuterium. We will discuss the limitations of enriching various compounds in stable isotopes when produced in living organisms. Finally, we overview methods for measuring stable isotopes, focusing on methods for detection in single cells in situ and their exploitation in modern biotechnologies.</description><identifier>ISSN: 0734-9750</identifier><identifier>EISSN: 1873-1899</identifier><identifier>DOI: 10.1016/j.biotechadv.2018.01.010</identifier><identifier>PMID: 29355599</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Algae ; Animals ; Archaeology ; Biology ; Biosynthesis ; Biotechnology - methods ; Carbon ; Chemical compounds ; Chlorophyta - growth & development ; Chlorophyta - metabolism ; Deuterium ; Deuterium - administration & dosage ; Deuterium - adverse effects ; Deuterium - analysis ; Drug Design ; Fluxes ; Isotope Labeling - methods ; Isotopes ; Isotopes - analysis ; Isotopes - chemistry ; Magnesium ; Magnetic Resonance Spectroscopy ; Mammals ; Mass Spectrometry - methods ; Measurement methods ; Nitrogen ; Oxygen ; Plants - drug effects ; Proteomics ; Raman spectroscopy ; Selenium ; Spectrum Analysis, Raman - methods ; Stable isotopes ; Sulfur ; Tracers</subject><ispartof>Biotechnology advances, 2018-05, Vol.36 (3), p.784-797</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. May/Jun 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-169bac82280d8e0df5cf2b95be1074b304c184e875201d206e6900b2db2ff8573</citedby><cites>FETCH-LOGICAL-c439t-169bac82280d8e0df5cf2b95be1074b304c184e875201d206e6900b2db2ff8573</cites><orcidid>0000-0003-1997-0894</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0734975018300107$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29355599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zachleder, Vilém</creatorcontrib><creatorcontrib>Vítová, Milada</creatorcontrib><creatorcontrib>Hlavová, Monika</creatorcontrib><creatorcontrib>Moudříková, Šárka</creatorcontrib><creatorcontrib>Mojzeš, Peter</creatorcontrib><creatorcontrib>Heumann, Hermann</creatorcontrib><creatorcontrib>Becher, Johannes R.</creatorcontrib><creatorcontrib>Bišová, Kateřina</creatorcontrib><title>Stable isotope compounds - production, detection, and application</title><title>Biotechnology advances</title><addtitle>Biotechnol Adv</addtitle><description>Stable isotopes are used in wide fields of application from natural tracers in biology, geology and archeology through studies of metabolic fluxes to their application as tracers in quantitative proteomics and structural biology. We review the use of stable isotopes of biogenic elements (H, C, N, O, S, Mg, Se) with the emphasis on hydrogen and its heavy isotope deuterium. We will discuss the limitations of enriching various compounds in stable isotopes when produced in living organisms. Finally, we overview methods for measuring stable isotopes, focusing on methods for detection in single cells in situ and their exploitation in modern biotechnologies.</description><subject>Algae</subject><subject>Animals</subject><subject>Archaeology</subject><subject>Biology</subject><subject>Biosynthesis</subject><subject>Biotechnology - methods</subject><subject>Carbon</subject><subject>Chemical compounds</subject><subject>Chlorophyta - growth & development</subject><subject>Chlorophyta - metabolism</subject><subject>Deuterium</subject><subject>Deuterium - administration & dosage</subject><subject>Deuterium - adverse effects</subject><subject>Deuterium - analysis</subject><subject>Drug Design</subject><subject>Fluxes</subject><subject>Isotope Labeling - methods</subject><subject>Isotopes</subject><subject>Isotopes - analysis</subject><subject>Isotopes - chemistry</subject><subject>Magnesium</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mammals</subject><subject>Mass Spectrometry - methods</subject><subject>Measurement methods</subject><subject>Nitrogen</subject><subject>Oxygen</subject><subject>Plants - drug effects</subject><subject>Proteomics</subject><subject>Raman spectroscopy</subject><subject>Selenium</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Stable isotopes</subject><subject>Sulfur</subject><subject>Tracers</subject><issn>0734-9750</issn><issn>1873-1899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQx4Mo7vr4ClLw4sGuk7Rpk-MqvkDwoJ5DHlPM0m1q0wp-e7OsD_AiDCSE3-Q_8yMko7CgQKuL1cL4MKJ91e59wYCKBdBUsEPmVNRFToWUu2QOdVHmsuYwIwcxrgAoB17skxmTBedcyjlZPo3atJj5GMbQY2bDug9T52KWZ_0Q3GRHH7rzzGGK21515zLd9623evNwRPYa3UY8_joPycvN9fPVXf7weHt_tXzIbVnIMaeVNNoKxgQ4geAabhtmJDdIoS5NAaWlokRR87SPY1BhJQEMc4Y1jeB1cUjOtv-msd4mjKNa-2ixbXWHYYqKyrQ0LVnFE3r6B12FaejSdIpBXRVVLeWGElvKDiHGARvVD36thw9FQW00q5X61aw2mhXQVJBaT74CJrNG99P47TUBl1sAk5F3j4OK1mNn0fkheVQu-P9TPgGfOZHg</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Zachleder, Vilém</creator><creator>Vítová, Milada</creator><creator>Hlavová, Monika</creator><creator>Moudříková, Šárka</creator><creator>Mojzeš, Peter</creator><creator>Heumann, Hermann</creator><creator>Becher, Johannes R.</creator><creator>Bišová, Kateřina</creator><general>Elsevier Inc</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QQ</scope><scope>7SE</scope><scope>7TA</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1997-0894</orcidid></search><sort><creationdate>20180501</creationdate><title>Stable isotope compounds - production, detection, and application</title><author>Zachleder, Vilém ; Vítová, Milada ; Hlavová, Monika ; Moudříková, Šárka ; Mojzeš, Peter ; Heumann, Hermann ; Becher, Johannes R. ; Bišová, Kateřina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-169bac82280d8e0df5cf2b95be1074b304c184e875201d206e6900b2db2ff8573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Algae</topic><topic>Animals</topic><topic>Archaeology</topic><topic>Biology</topic><topic>Biosynthesis</topic><topic>Biotechnology - methods</topic><topic>Carbon</topic><topic>Chemical compounds</topic><topic>Chlorophyta - growth & development</topic><topic>Chlorophyta - metabolism</topic><topic>Deuterium</topic><topic>Deuterium - administration & dosage</topic><topic>Deuterium - adverse effects</topic><topic>Deuterium - analysis</topic><topic>Drug Design</topic><topic>Fluxes</topic><topic>Isotope Labeling - methods</topic><topic>Isotopes</topic><topic>Isotopes - analysis</topic><topic>Isotopes - chemistry</topic><topic>Magnesium</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mammals</topic><topic>Mass Spectrometry - methods</topic><topic>Measurement methods</topic><topic>Nitrogen</topic><topic>Oxygen</topic><topic>Plants - drug effects</topic><topic>Proteomics</topic><topic>Raman spectroscopy</topic><topic>Selenium</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Stable isotopes</topic><topic>Sulfur</topic><topic>Tracers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zachleder, Vilém</creatorcontrib><creatorcontrib>Vítová, Milada</creatorcontrib><creatorcontrib>Hlavová, Monika</creatorcontrib><creatorcontrib>Moudříková, Šárka</creatorcontrib><creatorcontrib>Mojzeš, Peter</creatorcontrib><creatorcontrib>Heumann, Hermann</creatorcontrib><creatorcontrib>Becher, Johannes R.</creatorcontrib><creatorcontrib>Bišová, Kateřina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zachleder, Vilém</au><au>Vítová, Milada</au><au>Hlavová, Monika</au><au>Moudříková, Šárka</au><au>Mojzeš, Peter</au><au>Heumann, Hermann</au><au>Becher, Johannes R.</au><au>Bišová, Kateřina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stable isotope compounds - production, detection, and application</atitle><jtitle>Biotechnology advances</jtitle><addtitle>Biotechnol Adv</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>36</volume><issue>3</issue><spage>784</spage><epage>797</epage><pages>784-797</pages><issn>0734-9750</issn><eissn>1873-1899</eissn><abstract>Stable isotopes are used in wide fields of application from natural tracers in biology, geology and archeology through studies of metabolic fluxes to their application as tracers in quantitative proteomics and structural biology. We review the use of stable isotopes of biogenic elements (H, C, N, O, S, Mg, Se) with the emphasis on hydrogen and its heavy isotope deuterium. We will discuss the limitations of enriching various compounds in stable isotopes when produced in living organisms. Finally, we overview methods for measuring stable isotopes, focusing on methods for detection in single cells in situ and their exploitation in modern biotechnologies.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>29355599</pmid><doi>10.1016/j.biotechadv.2018.01.010</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-1997-0894</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0734-9750 |
| ispartof | Biotechnology advances, 2018-05, Vol.36 (3), p.784-797 |
| issn | 0734-9750 1873-1899 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1989914265 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Algae Animals Archaeology Biology Biosynthesis Biotechnology - methods Carbon Chemical compounds Chlorophyta - growth & development Chlorophyta - metabolism Deuterium Deuterium - administration & dosage Deuterium - adverse effects Deuterium - analysis Drug Design Fluxes Isotope Labeling - methods Isotopes Isotopes - analysis Isotopes - chemistry Magnesium Magnetic Resonance Spectroscopy Mammals Mass Spectrometry - methods Measurement methods Nitrogen Oxygen Plants - drug effects Proteomics Raman spectroscopy Selenium Spectrum Analysis, Raman - methods Stable isotopes Sulfur Tracers |
| title | Stable isotope compounds - production, detection, and application |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T04%3A15%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stable%20isotope%20compounds%20-%20production,%20detection,%20and%20application&rft.jtitle=Biotechnology%20advances&rft.au=Zachleder,%20Vil%C3%A9m&rft.date=2018-05-01&rft.volume=36&rft.issue=3&rft.spage=784&rft.epage=797&rft.pages=784-797&rft.issn=0734-9750&rft.eissn=1873-1899&rft_id=info:doi/10.1016/j.biotechadv.2018.01.010&rft_dat=%3Cproquest_cross%3E1989914265%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2076367995&rft_id=info:pmid/29355599&rft_els_id=S0734975018300107&rfr_iscdi=true |