Enteric α-defensins on the verge of intestinal immune tolerance and inflammation

[Display omitted] The gut is the biggest immune organ in the body that encloses commensal microbiota which aids in food digestion. Paneth cells, positioned at the frontline of host-microbiota interphase, can modulate the composition of microbiota. Paneth cells achieve this via the delivery of microb...

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Veröffentlicht in:	Seminars in cell & developmental biology 2019-04, Vol.88, p.138-146
Hauptverfasser:	Filipp, Dominik, Brabec, Tomáš, Vobořil, Matouš, Dobeš, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Defensins - biosynthesis alpha-Defensins - immunology alpha-Defensins - pharmacology Animals Autoimmunity Central Tolerance Dysbiosis - immunology Dysbiosis - microbiology Dysbiosis - prevention & control Enteric α-defensin Gastrointestinal Microbiome - immunology Gastrointestinal Tract - drug effects Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Gene Expression - immunology Homeostasis - immunology Humans Immunity, Mucosal - drug effects Inflammation Intestinal immune system Microbiota Paneth cell Paneth Cells - drug effects Paneth Cells - immunology Paneth Cells - microbiology Peripheral Tolerance Symbiosis - immunology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - microbiology
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