Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs
Objective To determine the differences in serum canine pancreatic lipase immunoreactivity between dogs with intervertebral disc herniation and healthy control dogs. Materials and Methods Eighty‐four client‐owned dogs with intervertebral disc herniation, diagnosed by neurologic examination and imagin...
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| Veröffentlicht in: | Journal of small animal practice 2018-05, Vol.59 (5), p.305-310 |
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| container_title | Journal of small animal practice |
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| creator | Schueler, R. O. White, G. Schueler, R. L. Steiner, J. M. Wassef, A. |
| description | Objective
To determine the differences in serum canine pancreatic lipase immunoreactivity between dogs with intervertebral disc herniation and healthy control dogs.
Materials and Methods
Eighty‐four client‐owned dogs with intervertebral disc herniation, diagnosed by neurologic examination and imaging, and 18 healthy control dogs. Samples of whole blood were collected within 90 minutes of admission. Serum canine pancreatic lipase immunoreactivity concentrations were measured by a commercial immunoassay and evaluated for association with intervertebral disc herniation, signalment, neurolocalisation and the preadmission administration of glucocorticosteriods or non‐steroidal anti‐inflammatory drugs.
Results
Serum canine pancreatic lipase immunoreactivity concentrations were statistically increased in dogs with intervertebral disc herniation (P |
| doi_str_mv | 10.1111/jsap.12818 |
| format | Article |
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To determine the differences in serum canine pancreatic lipase immunoreactivity between dogs with intervertebral disc herniation and healthy control dogs.
Materials and Methods
Eighty‐four client‐owned dogs with intervertebral disc herniation, diagnosed by neurologic examination and imaging, and 18 healthy control dogs. Samples of whole blood were collected within 90 minutes of admission. Serum canine pancreatic lipase immunoreactivity concentrations were measured by a commercial immunoassay and evaluated for association with intervertebral disc herniation, signalment, neurolocalisation and the preadmission administration of glucocorticosteriods or non‐steroidal anti‐inflammatory drugs.
Results
Serum canine pancreatic lipase immunoreactivity concentrations were statistically increased in dogs with intervertebral disc herniation (P<0·01, n=38). A subgroup of dogs (19/38) with elevated canine pancreatic lipase immunoreactivity concentrations was re‐evaluated between 2 and 4 weeks later, and 15 had resolution of clinical signs and values less than 200 μg/L. Serum canine pancreatic lipase immunoreactivity concentrations were not significantly correlated with clinical gastrointestinal disease, neurolocalisation or the preadmission administration of corticosteroids or non‐steroidal anti‐inflammatory drugs.
Clinical significance
These results suggest that serum canine pancreatic lipase immunoreactivity concentrations are significantly elevated in dogs with intervertebral disc herniation.</description><identifier>ISSN: 0022-4510</identifier><identifier>EISSN: 1748-5827</identifier><identifier>DOI: 10.1111/jsap.12818</identifier><identifier>PMID: 29355958</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Corticoids ; Corticosteroids ; Dogs ; Immunoreactivity ; Inflammation ; Lipase ; Pancreas</subject><ispartof>Journal of small animal practice, 2018-05, Vol.59 (5), p.305-310</ispartof><rights>2018 British Small Animal Veterinary Association</rights><rights>2018 British Small Animal Veterinary Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3578-b7371861b677454ec0e1dbf1af967e0f348d3b9b5a4a05a8deb5fedf6cc4d2073</citedby><cites>FETCH-LOGICAL-c3578-b7371861b677454ec0e1dbf1af967e0f348d3b9b5a4a05a8deb5fedf6cc4d2073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjsap.12818$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjsap.12818$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29355958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schueler, R. O.</creatorcontrib><creatorcontrib>White, G.</creatorcontrib><creatorcontrib>Schueler, R. L.</creatorcontrib><creatorcontrib>Steiner, J. M.</creatorcontrib><creatorcontrib>Wassef, A.</creatorcontrib><title>Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs</title><title>Journal of small animal practice</title><addtitle>J Small Anim Pract</addtitle><description>Objective
To determine the differences in serum canine pancreatic lipase immunoreactivity between dogs with intervertebral disc herniation and healthy control dogs.
Materials and Methods
Eighty‐four client‐owned dogs with intervertebral disc herniation, diagnosed by neurologic examination and imaging, and 18 healthy control dogs. Samples of whole blood were collected within 90 minutes of admission. Serum canine pancreatic lipase immunoreactivity concentrations were measured by a commercial immunoassay and evaluated for association with intervertebral disc herniation, signalment, neurolocalisation and the preadmission administration of glucocorticosteriods or non‐steroidal anti‐inflammatory drugs.
Results
Serum canine pancreatic lipase immunoreactivity concentrations were statistically increased in dogs with intervertebral disc herniation (P<0·01, n=38). A subgroup of dogs (19/38) with elevated canine pancreatic lipase immunoreactivity concentrations was re‐evaluated between 2 and 4 weeks later, and 15 had resolution of clinical signs and values less than 200 μg/L. Serum canine pancreatic lipase immunoreactivity concentrations were not significantly correlated with clinical gastrointestinal disease, neurolocalisation or the preadmission administration of corticosteroids or non‐steroidal anti‐inflammatory drugs.
Clinical significance
These results suggest that serum canine pancreatic lipase immunoreactivity concentrations are significantly elevated in dogs with intervertebral disc herniation.</description><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Dogs</subject><subject>Immunoreactivity</subject><subject>Inflammation</subject><subject>Lipase</subject><subject>Pancreas</subject><issn>0022-4510</issn><issn>1748-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rHSEUhqU0NDdpN_0BReimBCbVUUdnGS79CoEW2q7F0TOtlxmdqpNw_328uWkXXcSFcg4PDy--CL2m5JLW836XzXJJW0XVM7ShkqtGqFY-RxtC2rbhgpJTdJbzro4dl-QFOm17JkQv1AbFrQk-AF5MsAlM8RZPfjEZsJ_nNcS6s8Xf-rLHNgYLoaQKxZCxyTlabwo4fOfLb-xDgXQLqcCQzISdz_ZwwYMrYMWxi7_yS3QyminDq8f3HP38-OHH9nNz8_XTl-3VTWOZkKoZJJNUdXTopOSCgyVA3TBSM_adBDIyrhwb-kEYbogwysEgRnBjZy13LZHsHL07epcU_6yQi55rIJgmEyCuWdNe9T1lsqMVffsfuotrCjWdbgljnVKqP1AXR8qmmHOCUS_JzybtNSX6UIM-1KAfaqjwm0flOszg_qF__70C9Ajc-Qn2T6j09ferb0fpPWcglKM</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Schueler, R. O.</creator><creator>White, G.</creator><creator>Schueler, R. L.</creator><creator>Steiner, J. M.</creator><creator>Wassef, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs</title><author>Schueler, R. O. ; White, G. ; Schueler, R. L. ; Steiner, J. M. ; Wassef, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3578-b7371861b677454ec0e1dbf1af967e0f348d3b9b5a4a05a8deb5fedf6cc4d2073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Dogs</topic><topic>Immunoreactivity</topic><topic>Inflammation</topic><topic>Lipase</topic><topic>Pancreas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schueler, R. O.</creatorcontrib><creatorcontrib>White, G.</creatorcontrib><creatorcontrib>Schueler, R. L.</creatorcontrib><creatorcontrib>Steiner, J. M.</creatorcontrib><creatorcontrib>Wassef, A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of small animal practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schueler, R. O.</au><au>White, G.</au><au>Schueler, R. L.</au><au>Steiner, J. M.</au><au>Wassef, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs</atitle><jtitle>Journal of small animal practice</jtitle><addtitle>J Small Anim Pract</addtitle><date>2018-05</date><risdate>2018</risdate><volume>59</volume><issue>5</issue><spage>305</spage><epage>310</epage><pages>305-310</pages><issn>0022-4510</issn><eissn>1748-5827</eissn><abstract>Objective
To determine the differences in serum canine pancreatic lipase immunoreactivity between dogs with intervertebral disc herniation and healthy control dogs.
Materials and Methods
Eighty‐four client‐owned dogs with intervertebral disc herniation, diagnosed by neurologic examination and imaging, and 18 healthy control dogs. Samples of whole blood were collected within 90 minutes of admission. Serum canine pancreatic lipase immunoreactivity concentrations were measured by a commercial immunoassay and evaluated for association with intervertebral disc herniation, signalment, neurolocalisation and the preadmission administration of glucocorticosteriods or non‐steroidal anti‐inflammatory drugs.
Results
Serum canine pancreatic lipase immunoreactivity concentrations were statistically increased in dogs with intervertebral disc herniation (P<0·01, n=38). A subgroup of dogs (19/38) with elevated canine pancreatic lipase immunoreactivity concentrations was re‐evaluated between 2 and 4 weeks later, and 15 had resolution of clinical signs and values less than 200 μg/L. Serum canine pancreatic lipase immunoreactivity concentrations were not significantly correlated with clinical gastrointestinal disease, neurolocalisation or the preadmission administration of corticosteroids or non‐steroidal anti‐inflammatory drugs.
Clinical significance
These results suggest that serum canine pancreatic lipase immunoreactivity concentrations are significantly elevated in dogs with intervertebral disc herniation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>29355958</pmid><doi>10.1111/jsap.12818</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | Corticoids Corticosteroids Dogs Immunoreactivity Inflammation Lipase Pancreas |
| title | Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs |
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