Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for FcγRI in the pathogenesis of synovial inflammation

Anti-citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). Here, we studied binding of ACPA-IgG immune complexes (IC) to individual Fc gamma receptors (FcγR) to identify potential effector mechanisms by which ACPA could contribute to RA pathogenesis. ACPA-IgG1 an...

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Veröffentlicht in:	Clinical and experimental rheumatology 2018-03, Vol.36 (2), p.284-293
Hauptverfasser:	Kempers, Ayla C, Nejadnik, M Reza, Rombouts, Yoann, Ioan-Facsinay, Andreea, van Oosterhout, Maikel, Jiskoot, Wim, Huizinga, Tom W J, Toes, René E M, Scherer, Hans Ulrich
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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