Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents

[Display omitted] •Emergence of resistance has greatly hampered treatment of malaria and cancer.•Pyrazole acrylic acid based oxadiazole and amide derivatives were prepared.•Compound 6v emerged as the most potent antimalarial agent targeting falcipain-2.•Compound 6b′ was found to be most active antic...

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Veröffentlicht in:Bioorganic chemistry 2018-04, Vol.77, p.106-124
Hauptverfasser: Verma, Garima, Chashoo, Gousia, Ali, Asif, Khan, Mohemmed Faraz, Akhtar, Wasim, Ali, Israr, Akhtar, Mymoona, Alam, Mohammad Mumtaz, Shaquiquzzaman, Mohammad
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Sprache:eng
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