Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents
[Display omitted] •Emergence of resistance has greatly hampered treatment of malaria and cancer.•Pyrazole acrylic acid based oxadiazole and amide derivatives were prepared.•Compound 6v emerged as the most potent antimalarial agent targeting falcipain-2.•Compound 6b′ was found to be most active antic...
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Veröffentlicht in: | Bioorganic chemistry 2018-04, Vol.77, p.106-124 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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