Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii
Three new isopentylated diphenyl ethers, ( 1 – 3 ), together with two known isopentylated diphenyl ethers derivatives ( 4 and 5 ) were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii . Their structures were elucidated by spectroscopic methods, including extensive 1...
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| Veröffentlicht in: | Journal of antibiotics 2018-03, Vol.71 (3), p.359-362 |
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| container_title | Journal of antibiotics |
| container_volume | 71 |
| creator | Li, Zhen-Jie Yang, Hai-Ying Li, Jing Liu, Xin Ye, Lin Kong, Wei-Song Tang, Shi-Yun Du, Gang Liu, Zhi-Hua Zhou, Min Yang, Guang-Yu Hu, Qiu-Fen Li, Xue-Mei |
| description | Three new isopentylated diphenyl ethers, (
1
–
3
), together with two known isopentylated diphenyl ethers derivatives (
4
and
5
) were isolated from the fermentation products of an endophytic fungus
Phomopsis fukushii
. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds
1
–
3
were evaluated for their anti-methicillin-resistant
Staphylococcus aureus
(anti-MRSA) activity. The results showed that compounds
1–3
showed strong activity with diameter of inhibition zone (IZD) of 21.8 ± 2.4 mm, 16.8 ± 2.2 mm, and 15.6 ± 2.0 mm, respectively. |
| doi_str_mv | 10.1038/s41429-017-0006-y |
| format | Article |
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1
–
3
), together with two known isopentylated diphenyl ethers derivatives (
4
and
5
) were isolated from the fermentation products of an endophytic fungus
Phomopsis fukushii
. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds
1
–
3
were evaluated for their anti-methicillin-resistant
Staphylococcus aureus
(anti-MRSA) activity. The results showed that compounds
1–3
showed strong activity with diameter of inhibition zone (IZD) of 21.8 ± 2.4 mm, 16.8 ± 2.2 mm, and 15.6 ± 2.0 mm, respectively.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/s41429-017-0006-y</identifier><identifier>PMID: 29348531</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/1 ; 692/308 ; 692/308/153 ; 82/16 ; Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Ascomycota - chemistry ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Biphenyl Compounds - isolation & purification ; Biphenyl Compounds - pharmacology ; Ethers ; Fermentation ; Life Sciences ; Magnetic Resonance Spectroscopy ; Medicinal Chemistry ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Microbial Sensitivity Tests ; Microbiology ; Organic Chemistry ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Ultraviolet ; Staphylococcus infections</subject><ispartof>Journal of antibiotics, 2018-03, Vol.71 (3), p.359-362</ispartof><rights>Japan Antibiotics Research Association 2018</rights><rights>Copyright Nature Publishing Group Mar 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-542b06e57e654b3f2ac5e5606fc4bdcca886887519c2f5887099f28dcda431b83</citedby><cites>FETCH-LOGICAL-c415t-542b06e57e654b3f2ac5e5606fc4bdcca886887519c2f5887099f28dcda431b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29348531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhen-Jie</creatorcontrib><creatorcontrib>Yang, Hai-Ying</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Ye, Lin</creatorcontrib><creatorcontrib>Kong, Wei-Song</creatorcontrib><creatorcontrib>Tang, Shi-Yun</creatorcontrib><creatorcontrib>Du, Gang</creatorcontrib><creatorcontrib>Liu, Zhi-Hua</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Yang, Guang-Yu</creatorcontrib><creatorcontrib>Hu, Qiu-Fen</creatorcontrib><creatorcontrib>Li, Xue-Mei</creatorcontrib><title>Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>Three new isopentylated diphenyl ethers, (
1
–
3
), together with two known isopentylated diphenyl ethers derivatives (
4
and
5
) were isolated from the fermentation products of an endophytic fungus
Phomopsis fukushii
. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds
1
–
3
were evaluated for their anti-methicillin-resistant
Staphylococcus aureus
(anti-MRSA) activity. The results showed that compounds
1–3
showed strong activity with diameter of inhibition zone (IZD) of 21.8 ± 2.4 mm, 16.8 ± 2.2 mm, and 15.6 ± 2.0 mm, respectively.</description><subject>101/1</subject><subject>692/308</subject><subject>692/308/153</subject><subject>82/16</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Ascomycota - chemistry</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Biphenyl Compounds - isolation & purification</subject><subject>Biphenyl Compounds - pharmacology</subject><subject>Ethers</subject><subject>Fermentation</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Staphylococcus infections</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kV9r3iAUh2VsrG_bfYDdDGE3u8l2NJro5Sj7Uyh0F-u1JObYpEs001jIt6_l7VYY7Eo5Pr-fBx5C3jL4yKBWn5JggusKWFsBQFPtL8iBKcUqJhr9khwAOKuU4nBCTlO6A6jbulWvyQnXtVCyZgcSL1NY0W_73G040GFaR_T7THEbMdIB43TfbdM9JupiWGiZUodxKYkyDp6uMQzZbokGRztP0Q9hHfdtstRlf5sT_TGGJaxpKgX5V07jNJ2TV66bE755Os_IzdcvPy--V1fX3y4vPl9VVjC5VVLwHhqULTZS9LXjnZUoG2icFf1gbadUo1QrmbbcyXIDrR1Xgx06UbNe1Wfkw7G37Pg7Y9rMMiWL89x5DDkZppVuQKtaFvT9P-hdyNGX7QwHKARrWlEodqRsDClFdGaN09LF3TAwj0LMUYgpQsyjELOXzLun5twvOPxN_DFQAH4EUnnytxifv_5_6wNZt5ix</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Li, Zhen-Jie</creator><creator>Yang, Hai-Ying</creator><creator>Li, Jing</creator><creator>Liu, Xin</creator><creator>Ye, Lin</creator><creator>Kong, Wei-Song</creator><creator>Tang, Shi-Yun</creator><creator>Du, Gang</creator><creator>Liu, Zhi-Hua</creator><creator>Zhou, Min</creator><creator>Yang, Guang-Yu</creator><creator>Hu, Qiu-Fen</creator><creator>Li, Xue-Mei</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii</title><author>Li, Zhen-Jie ; Yang, Hai-Ying ; Li, Jing ; Liu, Xin ; Ye, Lin ; Kong, Wei-Song ; Tang, Shi-Yun ; Du, Gang ; Liu, Zhi-Hua ; Zhou, Min ; Yang, Guang-Yu ; Hu, Qiu-Fen ; Li, Xue-Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-542b06e57e654b3f2ac5e5606fc4bdcca886887519c2f5887099f28dcda431b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>101/1</topic><topic>692/308</topic><topic>692/308/153</topic><topic>82/16</topic><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Ascomycota - chemistry</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Biphenyl Compounds - isolation & purification</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>Ethers</topic><topic>Fermentation</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medicinal Chemistry</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Staphylococcus infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhen-Jie</creatorcontrib><creatorcontrib>Yang, Hai-Ying</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Ye, Lin</creatorcontrib><creatorcontrib>Kong, Wei-Song</creatorcontrib><creatorcontrib>Tang, Shi-Yun</creatorcontrib><creatorcontrib>Du, Gang</creatorcontrib><creatorcontrib>Liu, Zhi-Hua</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Yang, Guang-Yu</creatorcontrib><creatorcontrib>Hu, Qiu-Fen</creatorcontrib><creatorcontrib>Li, Xue-Mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhen-Jie</au><au>Yang, Hai-Ying</au><au>Li, Jing</au><au>Liu, Xin</au><au>Ye, Lin</au><au>Kong, Wei-Song</au><au>Tang, Shi-Yun</au><au>Du, Gang</au><au>Liu, Zhi-Hua</au><au>Zhou, Min</au><au>Yang, Guang-Yu</au><au>Hu, Qiu-Fen</au><au>Li, Xue-Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>71</volume><issue>3</issue><spage>359</spage><epage>362</epage><pages>359-362</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Three new isopentylated diphenyl ethers, (
1
–
3
), together with two known isopentylated diphenyl ethers derivatives (
4
and
5
) were isolated from the fermentation products of an endophytic fungus
Phomopsis fukushii
. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds
1
–
3
were evaluated for their anti-methicillin-resistant
Staphylococcus aureus
(anti-MRSA) activity. The results showed that compounds
1–3
showed strong activity with diameter of inhibition zone (IZD) of 21.8 ± 2.4 mm, 16.8 ± 2.2 mm, and 15.6 ± 2.0 mm, respectively.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29348531</pmid><doi>10.1038/s41429-017-0006-y</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | Journal of antibiotics, 2018-03, Vol.71 (3), p.359-362 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1989609835 |
| source | MEDLINE; EZB Electronic Journals Library |
| subjects | 101/1 692/308 692/308/153 82/16 Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Ascomycota - chemistry Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Biphenyl Compounds - isolation & purification Biphenyl Compounds - pharmacology Ethers Fermentation Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Microbiology Organic Chemistry Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet Staphylococcus infections |
| title | Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii |
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