Serum thiol levels and thiol/disulphide homeostasis in gunshot injuries
Background Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, deep penetration, and ballistic effect. Trauma is known to be related with oxidative stress. Serum thiol levels and disulphide/thiol homeostasis are novel oxidative stress biomarkers. In this st...
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| Veröffentlicht in: | European journal of trauma and emergency surgery (Munich : 2007) 2019-02, Vol.45 (1), p.167-174 |
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| creator | Buyukaslan, Hasan Gulacti, Umut Gökdemir, Mehmet Tahir Giden, Ramazan Celik, Hakim Erel, Özcan Dörterler, Erman Mustafa |
| description | Background
Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, deep penetration, and ballistic effect. Trauma is known to be related with oxidative stress. Serum thiol levels and disulphide/thiol homeostasis are novel oxidative stress biomarkers. In this study, we aimed to investigate serum thiol levels and disulphide/thiol homeostasis in injury patterns of patients admitted to the emergency department with a gunshot injury.
Method
A total of 128 participants were included in the study. The participants were divided into two groups: the patient group (Group 1;
n
= 73) and healthy controls (Group 2;
n
= 55). Native thiol, total thiol, disulphide levels, disulphide/native thiol, disulphide/total thiol, and neutrophil-to-lymphocyte ratio (NLR) were measured. The Revised Trauma Scale (RTS) and Glasgow Coma Scale (GCS) scores were calculated.
Results
Native thiol, total thiol, and disulphide levels were significantly lower in Group 1 (
p
|
| doi_str_mv | 10.1007/s00068-017-0900-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1989606949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1992792840</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-1874a329ac85c5f4434ef5fee88207f3d77b119cc3c003f054b8d76c99097e23</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMofv8AL1Lw4qXuJGmb5CjiFwge3HvoptPdLP1YM63gvzdLVxHBU4bkmXcyD2MXHG44gJoRABQ6Ba5SMACp2WPHXBcyNSbj-z-1lEfshGgdYShycciOhJFCiUIfs8c3DGObDCvfN0mDH9hQUnbVdDGrPI3NZuUrTFZ9iz0NJXlKfJcsx45W_RDL9Rg80hk7qMuG8Hx3nrL5w_387il9eX18vrt9SZ1UYki5VlkphSmdzl1eZ5nMsM5rRK0FqFpWSi04N85JByBryLOFrlThjAGjUMhTdj3FbkL_PiINtvXksGnKDvuRLDfaxCVNZiJ69Qdd92Po4uciZYQyQmcQKT5RLvREAWu7Cb4tw6flYLeS7STZRsl2K9luky93yeOixeqn49tqBMQEUHzqlhh-jf439QsbfYZq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1992792840</pqid></control><display><type>article</type><title>Serum thiol levels and thiol/disulphide homeostasis in gunshot injuries</title><source>SpringerLink Journals - AutoHoldings</source><creator>Buyukaslan, Hasan ; Gulacti, Umut ; Gökdemir, Mehmet Tahir ; Giden, Ramazan ; Celik, Hakim ; Erel, Özcan ; Dörterler, Erman Mustafa</creator><creatorcontrib>Buyukaslan, Hasan ; Gulacti, Umut ; Gökdemir, Mehmet Tahir ; Giden, Ramazan ; Celik, Hakim ; Erel, Özcan ; Dörterler, Erman Mustafa</creatorcontrib><description>Background
Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, deep penetration, and ballistic effect. Trauma is known to be related with oxidative stress. Serum thiol levels and disulphide/thiol homeostasis are novel oxidative stress biomarkers. In this study, we aimed to investigate serum thiol levels and disulphide/thiol homeostasis in injury patterns of patients admitted to the emergency department with a gunshot injury.
Method
A total of 128 participants were included in the study. The participants were divided into two groups: the patient group (Group 1;
n
= 73) and healthy controls (Group 2;
n
= 55). Native thiol, total thiol, disulphide levels, disulphide/native thiol, disulphide/total thiol, and neutrophil-to-lymphocyte ratio (NLR) were measured. The Revised Trauma Scale (RTS) and Glasgow Coma Scale (GCS) scores were calculated.
Results
Native thiol, total thiol, and disulphide levels were significantly lower in Group 1 (
p
< 0.001). Disulphide/native thiol ratio, disulphide/total thiol ratio, and NLR were significantly higher in Group 1, compared to Group 2 (
p
< 0.05). There was a positive correlation between thiol levels and RTS and GCS scores and NLR. Stepwise linear regression analysis showed that native thiol was an independent indicator of RTS and GCS scores. The receiver operating characteristic curve (ROC) analysis revealed that serum native thiol levels of ≤ 342.9 could predict gunshot injury with a sensitivity of 82% and a specificity of 77% (area under the curve = 0.853; 95% confidence interval 0.783–0.924).
Conclusion
Our study results suggest that thiol–disulphide homeostasis is disrupted in patients sustaining gunshot injuries, and thiol levels decrease in correlation with the severity of trauma with a high sensitivity and specificity. As the level of native thiol is an independent predictor of the severity of trauma, reduced thiol levels may be of prognostic value in the early assessment of patients in the emergency room.</description><identifier>ISSN: 1863-9933</identifier><identifier>EISSN: 1863-9941</identifier><identifier>DOI: 10.1007/s00068-017-0900-9</identifier><identifier>PMID: 29327268</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Critical Care Medicine ; Emergency medical care ; Emergency Medicine ; Homeostasis ; Injuries ; Intensive ; Medicine ; Medicine & Public Health ; Original Article ; Oxidative stress ; Sports Medicine ; Surgery ; Surgical Orthopedics ; Trauma ; Traumatic Surgery</subject><ispartof>European journal of trauma and emergency surgery (Munich : 2007), 2019-02, Vol.45 (1), p.167-174</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>European Journal of Trauma and Emergency Surgery is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-1874a329ac85c5f4434ef5fee88207f3d77b119cc3c003f054b8d76c99097e23</citedby><cites>FETCH-LOGICAL-c372t-1874a329ac85c5f4434ef5fee88207f3d77b119cc3c003f054b8d76c99097e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00068-017-0900-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00068-017-0900-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29327268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buyukaslan, Hasan</creatorcontrib><creatorcontrib>Gulacti, Umut</creatorcontrib><creatorcontrib>Gökdemir, Mehmet Tahir</creatorcontrib><creatorcontrib>Giden, Ramazan</creatorcontrib><creatorcontrib>Celik, Hakim</creatorcontrib><creatorcontrib>Erel, Özcan</creatorcontrib><creatorcontrib>Dörterler, Erman Mustafa</creatorcontrib><title>Serum thiol levels and thiol/disulphide homeostasis in gunshot injuries</title><title>European journal of trauma and emergency surgery (Munich : 2007)</title><addtitle>Eur J Trauma Emerg Surg</addtitle><addtitle>Eur J Trauma Emerg Surg</addtitle><description>Background
Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, deep penetration, and ballistic effect. Trauma is known to be related with oxidative stress. Serum thiol levels and disulphide/thiol homeostasis are novel oxidative stress biomarkers. In this study, we aimed to investigate serum thiol levels and disulphide/thiol homeostasis in injury patterns of patients admitted to the emergency department with a gunshot injury.
Method
A total of 128 participants were included in the study. The participants were divided into two groups: the patient group (Group 1;
n
= 73) and healthy controls (Group 2;
n
= 55). Native thiol, total thiol, disulphide levels, disulphide/native thiol, disulphide/total thiol, and neutrophil-to-lymphocyte ratio (NLR) were measured. The Revised Trauma Scale (RTS) and Glasgow Coma Scale (GCS) scores were calculated.
Results
Native thiol, total thiol, and disulphide levels were significantly lower in Group 1 (
p
< 0.001). Disulphide/native thiol ratio, disulphide/total thiol ratio, and NLR were significantly higher in Group 1, compared to Group 2 (
p
< 0.05). There was a positive correlation between thiol levels and RTS and GCS scores and NLR. Stepwise linear regression analysis showed that native thiol was an independent indicator of RTS and GCS scores. The receiver operating characteristic curve (ROC) analysis revealed that serum native thiol levels of ≤ 342.9 could predict gunshot injury with a sensitivity of 82% and a specificity of 77% (area under the curve = 0.853; 95% confidence interval 0.783–0.924).
Conclusion
Our study results suggest that thiol–disulphide homeostasis is disrupted in patients sustaining gunshot injuries, and thiol levels decrease in correlation with the severity of trauma with a high sensitivity and specificity. As the level of native thiol is an independent predictor of the severity of trauma, reduced thiol levels may be of prognostic value in the early assessment of patients in the emergency room.</description><subject>Critical Care Medicine</subject><subject>Emergency medical care</subject><subject>Emergency Medicine</subject><subject>Homeostasis</subject><subject>Injuries</subject><subject>Intensive</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Sports Medicine</subject><subject>Surgery</subject><subject>Surgical Orthopedics</subject><subject>Trauma</subject><subject>Traumatic Surgery</subject><issn>1863-9933</issn><issn>1863-9941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1LxDAQhoMofv8AL1Lw4qXuJGmb5CjiFwge3HvoptPdLP1YM63gvzdLVxHBU4bkmXcyD2MXHG44gJoRABQ6Ba5SMACp2WPHXBcyNSbj-z-1lEfshGgdYShycciOhJFCiUIfs8c3DGObDCvfN0mDH9hQUnbVdDGrPI3NZuUrTFZ9iz0NJXlKfJcsx45W_RDL9Rg80hk7qMuG8Hx3nrL5w_387il9eX18vrt9SZ1UYki5VlkphSmdzl1eZ5nMsM5rRK0FqFpWSi04N85JByBryLOFrlThjAGjUMhTdj3FbkL_PiINtvXksGnKDvuRLDfaxCVNZiJ69Qdd92Po4uciZYQyQmcQKT5RLvREAWu7Cb4tw6flYLeS7STZRsl2K9luky93yeOixeqn49tqBMQEUHzqlhh-jf439QsbfYZq</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Buyukaslan, Hasan</creator><creator>Gulacti, Umut</creator><creator>Gökdemir, Mehmet Tahir</creator><creator>Giden, Ramazan</creator><creator>Celik, Hakim</creator><creator>Erel, Özcan</creator><creator>Dörterler, Erman Mustafa</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20190201</creationdate><title>Serum thiol levels and thiol/disulphide homeostasis in gunshot injuries</title><author>Buyukaslan, Hasan ; Gulacti, Umut ; Gökdemir, Mehmet Tahir ; Giden, Ramazan ; Celik, Hakim ; Erel, Özcan ; Dörterler, Erman Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-1874a329ac85c5f4434ef5fee88207f3d77b119cc3c003f054b8d76c99097e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Critical Care Medicine</topic><topic>Emergency medical care</topic><topic>Emergency Medicine</topic><topic>Homeostasis</topic><topic>Injuries</topic><topic>Intensive</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Sports Medicine</topic><topic>Surgery</topic><topic>Surgical Orthopedics</topic><topic>Trauma</topic><topic>Traumatic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buyukaslan, Hasan</creatorcontrib><creatorcontrib>Gulacti, Umut</creatorcontrib><creatorcontrib>Gökdemir, Mehmet Tahir</creatorcontrib><creatorcontrib>Giden, Ramazan</creatorcontrib><creatorcontrib>Celik, Hakim</creatorcontrib><creatorcontrib>Erel, Özcan</creatorcontrib><creatorcontrib>Dörterler, Erman Mustafa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of trauma and emergency surgery (Munich : 2007)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buyukaslan, Hasan</au><au>Gulacti, Umut</au><au>Gökdemir, Mehmet Tahir</au><au>Giden, Ramazan</au><au>Celik, Hakim</au><au>Erel, Özcan</au><au>Dörterler, Erman Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum thiol levels and thiol/disulphide homeostasis in gunshot injuries</atitle><jtitle>European journal of trauma and emergency surgery (Munich : 2007)</jtitle><stitle>Eur J Trauma Emerg Surg</stitle><addtitle>Eur J Trauma Emerg Surg</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>45</volume><issue>1</issue><spage>167</spage><epage>174</epage><pages>167-174</pages><issn>1863-9933</issn><eissn>1863-9941</eissn><abstract>Background
Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, deep penetration, and ballistic effect. Trauma is known to be related with oxidative stress. Serum thiol levels and disulphide/thiol homeostasis are novel oxidative stress biomarkers. In this study, we aimed to investigate serum thiol levels and disulphide/thiol homeostasis in injury patterns of patients admitted to the emergency department with a gunshot injury.
Method
A total of 128 participants were included in the study. The participants were divided into two groups: the patient group (Group 1;
n
= 73) and healthy controls (Group 2;
n
= 55). Native thiol, total thiol, disulphide levels, disulphide/native thiol, disulphide/total thiol, and neutrophil-to-lymphocyte ratio (NLR) were measured. The Revised Trauma Scale (RTS) and Glasgow Coma Scale (GCS) scores were calculated.
Results
Native thiol, total thiol, and disulphide levels were significantly lower in Group 1 (
p
< 0.001). Disulphide/native thiol ratio, disulphide/total thiol ratio, and NLR were significantly higher in Group 1, compared to Group 2 (
p
< 0.05). There was a positive correlation between thiol levels and RTS and GCS scores and NLR. Stepwise linear regression analysis showed that native thiol was an independent indicator of RTS and GCS scores. The receiver operating characteristic curve (ROC) analysis revealed that serum native thiol levels of ≤ 342.9 could predict gunshot injury with a sensitivity of 82% and a specificity of 77% (area under the curve = 0.853; 95% confidence interval 0.783–0.924).
Conclusion
Our study results suggest that thiol–disulphide homeostasis is disrupted in patients sustaining gunshot injuries, and thiol levels decrease in correlation with the severity of trauma with a high sensitivity and specificity. As the level of native thiol is an independent predictor of the severity of trauma, reduced thiol levels may be of prognostic value in the early assessment of patients in the emergency room.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29327268</pmid><doi>10.1007/s00068-017-0900-9</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1863-9933 |
| ispartof | European journal of trauma and emergency surgery (Munich : 2007), 2019-02, Vol.45 (1), p.167-174 |
| issn | 1863-9933 1863-9941 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Critical Care Medicine Emergency medical care Emergency Medicine Homeostasis Injuries Intensive Medicine Medicine & Public Health Original Article Oxidative stress Sports Medicine Surgery Surgical Orthopedics Trauma Traumatic Surgery |
| title | Serum thiol levels and thiol/disulphide homeostasis in gunshot injuries |
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