Clinical and genetic associations for carboplatin‐related ototoxicity in children treated for retinoblastoma: A retrospective noncomparative single‐institute experience

Background Children with retinoblastoma treated with carboplatin chemotherapy risk moderate to severe, irreversible hearing loss. Based on published evidence, we hypothesized that ototoxicity risk is associated with clinical parameters and variants in candidate genes in drug metabolism pathways (met...

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Veröffentlicht in:	Pediatric blood & cancer 2018-05, Vol.65 (5), p.e26931-n/a
Hauptverfasser:	Soliman, Sameh E., D'Silva, Crystal N., Dimaras, Helen, Dzneladze, Irakli, Chan, Helen, Gallie, Brenda L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alleles Antineoplastic Agents - adverse effects Cancer Carboplatin Carboplatin - adverse effects Catechol Catechol O-methyltransferase Catechol O-Methyltransferase - genetics Chemotherapy Child Child, Preschool Children Deoxyribonucleic acid Diagnosis DNA Drug dosages Drug metabolism Female Follow-Up Studies Genetic diversity Genetic Markers Genetic variance genetics Hearing loss Hearing Loss - chemically induced Hearing Loss - diagnosis Hearing Loss - genetics Hematology Humans Infant Likelihood ratio Male Methyltransferase Methyltransferases - genetics Multidrug Resistance-Associated Proteins - genetics Oncology Ototoxicity Pediatrics Polymerase chain reaction Polymorphism, Single Nucleotide Prognosis Retina Retinal Neoplasms - drug therapy Retinal Neoplasms - pathology Retinoblastoma Retinoblastoma - drug therapy Retinoblastoma - pathology Retrospective Studies Statistical analysis Tumors
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