Impaired detoxication of hydrogen sulfide in ulcerative colitis?
Impaired butyrate oxidation and raised counts of sulfate-reducing bacteria in the colon of patients with ulcerative colitis (UC) indicate that the disease may be induced or aggravated by hydrogen sulfide toxicity. We aimed to examine enzymatic removal of H(2)S in erythrocytes and colonic mucosa from...
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| Veröffentlicht in: | Digestive diseases and sciences 2007-02, Vol.52 (2), p.373-378 |
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| description | Impaired butyrate oxidation and raised counts of sulfate-reducing bacteria in the colon of patients with ulcerative colitis (UC) indicate that the disease may be induced or aggravated by hydrogen sulfide toxicity. We aimed to examine enzymatic removal of H(2)S in erythrocytes and colonic mucosa from controls and patients with UC and Crohn's disease (CD). Rhodanese (RHOD) and thiol methyltransferase (TMT) activities were measured in rectal mucosa and erythrocytes, and plasma thiocyanate was determined. Four groups were analyzed: patients with UC, patients with CD, hospital controls (patients with dyspepsia or IBS), and a group of healthy volunteers. RHOD and TMT activity in rectal biopsies did not differ significantly between controls and patients with UC or CD (n=56). Control levels of RHOD were significantly higher in men than in women (212+/-25 and 132+/-14 nmol/mg/min, respectively; P |
| doi_str_mv | 10.1007/s10620-006-9529-y |
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C ; LANGMAN, M. J. S ; SINGH, S</creator><creatorcontrib>PICTON, R ; EGGO, M. C ; LANGMAN, M. J. S ; SINGH, S</creatorcontrib><description>Impaired butyrate oxidation and raised counts of sulfate-reducing bacteria in the colon of patients with ulcerative colitis (UC) indicate that the disease may be induced or aggravated by hydrogen sulfide toxicity. We aimed to examine enzymatic removal of H(2)S in erythrocytes and colonic mucosa from controls and patients with UC and Crohn's disease (CD). Rhodanese (RHOD) and thiol methyltransferase (TMT) activities were measured in rectal mucosa and erythrocytes, and plasma thiocyanate was determined. Four groups were analyzed: patients with UC, patients with CD, hospital controls (patients with dyspepsia or IBS), and a group of healthy volunteers. RHOD and TMT activity in rectal biopsies did not differ significantly between controls and patients with UC or CD (n=56). Control levels of RHOD were significantly higher in men than in women (212+/-25 and 132+/-14 nmol/mg/min, respectively; P<0.01). In erythrocytes (n=128) RHOD activity was significantly higher in UC patients than in hospital or volunteer controls (1.15+/-0.12 compared with 0.88+/-0.12 and 0.66+/-0.02 nmol/mg/min; P<0.05 and P<0.02, respectively). TMT activity was also significantly higher in erythrocytes from UC patients and hospital controls than volunteer controls (2.02+/-0.13 pmol/mg/min [P<0.001], 1.51+/-0.21 pmol/mg/min [P<0.05], and 1.17+/-0.18 pmol/mg/min, respectively). We found no evidence of defective enzymic detoxication of sulfide by RHOD or TMT in patients with UC or CD.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-006-9529-y</identifier><identifier>PMID: 17216575</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Biological and medical sciences ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - metabolism ; Crohn Disease - blood ; Crohn Disease - metabolism ; Erythrocytes - enzymology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hydrogen Sulfide - metabolism ; Male ; Medical sciences ; Methyltransferases - metabolism ; Middle Aged ; Mucous Membrane - enzymology ; Other diseases. Semiology ; Rectum - enzymology ; Severity of Illness Index ; Stomach. Duodenum. Small intestine. 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C</creatorcontrib><creatorcontrib>LANGMAN, M. J. S</creatorcontrib><creatorcontrib>SINGH, S</creatorcontrib><title>Impaired detoxication of hydrogen sulfide in ulcerative colitis?</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Impaired butyrate oxidation and raised counts of sulfate-reducing bacteria in the colon of patients with ulcerative colitis (UC) indicate that the disease may be induced or aggravated by hydrogen sulfide toxicity. We aimed to examine enzymatic removal of H(2)S in erythrocytes and colonic mucosa from controls and patients with UC and Crohn's disease (CD). Rhodanese (RHOD) and thiol methyltransferase (TMT) activities were measured in rectal mucosa and erythrocytes, and plasma thiocyanate was determined. Four groups were analyzed: patients with UC, patients with CD, hospital controls (patients with dyspepsia or IBS), and a group of healthy volunteers. RHOD and TMT activity in rectal biopsies did not differ significantly between controls and patients with UC or CD (n=56). Control levels of RHOD were significantly higher in men than in women (212+/-25 and 132+/-14 nmol/mg/min, respectively; P<0.01). In erythrocytes (n=128) RHOD activity was significantly higher in UC patients than in hospital or volunteer controls (1.15+/-0.12 compared with 0.88+/-0.12 and 0.66+/-0.02 nmol/mg/min; P<0.05 and P<0.02, respectively). TMT activity was also significantly higher in erythrocytes from UC patients and hospital controls than volunteer controls (2.02+/-0.13 pmol/mg/min [P<0.001], 1.51+/-0.21 pmol/mg/min [P<0.05], and 1.17+/-0.18 pmol/mg/min, respectively). We found no evidence of defective enzymic detoxication of sulfide by RHOD or TMT in patients with UC or CD.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - metabolism</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - metabolism</subject><subject>Erythrocytes - enzymology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hydrogen Sulfide - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methyltransferases - metabolism</subject><subject>Middle Aged</subject><subject>Mucous Membrane - enzymology</subject><subject>Other diseases. 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C</au><au>LANGMAN, M. J. S</au><au>SINGH, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired detoxication of hydrogen sulfide in ulcerative colitis?</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>52</volume><issue>2</issue><spage>373</spage><epage>378</epage><pages>373-378</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Impaired butyrate oxidation and raised counts of sulfate-reducing bacteria in the colon of patients with ulcerative colitis (UC) indicate that the disease may be induced or aggravated by hydrogen sulfide toxicity. We aimed to examine enzymatic removal of H(2)S in erythrocytes and colonic mucosa from controls and patients with UC and Crohn's disease (CD). Rhodanese (RHOD) and thiol methyltransferase (TMT) activities were measured in rectal mucosa and erythrocytes, and plasma thiocyanate was determined. Four groups were analyzed: patients with UC, patients with CD, hospital controls (patients with dyspepsia or IBS), and a group of healthy volunteers. RHOD and TMT activity in rectal biopsies did not differ significantly between controls and patients with UC or CD (n=56). Control levels of RHOD were significantly higher in men than in women (212+/-25 and 132+/-14 nmol/mg/min, respectively; P<0.01). In erythrocytes (n=128) RHOD activity was significantly higher in UC patients than in hospital or volunteer controls (1.15+/-0.12 compared with 0.88+/-0.12 and 0.66+/-0.02 nmol/mg/min; P<0.05 and P<0.02, respectively). TMT activity was also significantly higher in erythrocytes from UC patients and hospital controls than volunteer controls (2.02+/-0.13 pmol/mg/min [P<0.001], 1.51+/-0.21 pmol/mg/min [P<0.05], and 1.17+/-0.18 pmol/mg/min, respectively). We found no evidence of defective enzymic detoxication of sulfide by RHOD or TMT in patients with UC or CD.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>17216575</pmid><doi>10.1007/s10620-006-9529-y</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Colitis, Ulcerative - blood Colitis, Ulcerative - metabolism Crohn Disease - blood Crohn Disease - metabolism Erythrocytes - enzymology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Humans Hydrogen Sulfide - metabolism Male Medical sciences Methyltransferases - metabolism Middle Aged Mucous Membrane - enzymology Other diseases. Semiology Rectum - enzymology Severity of Illness Index Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thiocyanates - blood Thiosulfate Sulfurtransferase - metabolism United Kingdom Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Impaired detoxication of hydrogen sulfide in ulcerative colitis? |
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