Detrimental effects of 2-arachidonoylglycerol on whole blood platelet aggregation and on cerebral blood flow after a focal ischemic insult in rats

2-Arachidonoylglycerol (2-AG) is a major modulator of blood flow and platelet aggregation and a potential neuroprotectant. The present study investigated, for the first time, the effects of 2-AG on cerebral blood flow (CBF) in the first critical hours during middle cerebral artery occlusion (MCAO) a...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2018-05, Vol.314 (5), p.H967-H977
Hauptverfasser:	Shearer, Jennifer A, Coker, Susan J, Carswell, Hilary V O
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonoylglycerol Agglomeration Anesthesia Animals Arachidonic acid Arachidonic Acids - toxicity Blood flow Blood platelets Blood Platelets - drug effects Blood Platelets - metabolism Blood pressure Cardiovascular system Cerebral blood flow Cerebrovascular Circulation - drug effects Disease Models, Animal Endocannabinoids - toxicity Flurbiprofen Glycerides - toxicity Heart rate Heatstroke Indomethacin Infarction, Middle Cerebral Artery - blood Infarction, Middle Cerebral Artery - physiopathology Interrogation Ischemia Isoflurane Laboratory animals Lipase Male Medical treatment Neuroprotection Neuroprotective agents Neuroprotective Agents - toxicity Occlusion Platelet aggregation Platelet Aggregation - drug effects Pressure effects Prostaglandin endoperoxide synthase Prostaglandin-Endoperoxide Synthases - blood Rats Rats, Sprague-Dawley Severity of Illness Index Thromboxane A2 - blood Time Factors
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