High density lipoprotein with apolipoprotein C-III is associated with carotid intima-media thickness among generally healthy individuals
About 6–7% of high density lipoprotein (HDL) has a protein called apolipoprotein (apo) C-III that regulates lipoprotein metabolism and can provoke an inflammatory response. HDL without apoC-III is inversely associated with coronary heart disease (CHD), whereas HDL with apoC-III is directly associate...
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| Veröffentlicht in: | Atherosclerosis 2018-02, Vol.269, p.92-99 |
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| creator | Yamamoto, Rain Sacks, Frank M. Hu, Frank B. Rosner, Bernard Furtado, Jeremy D. Aroner, Sarah A. Ferrannini, Ele Baldi, Simona Kozakova, Michaela Balkau, Beverley Natali, Andrea Jensen, Majken K. |
| description | About 6–7% of high density lipoprotein (HDL) has a protein called apolipoprotein (apo) C-III that regulates lipoprotein metabolism and can provoke an inflammatory response. HDL without apoC-III is inversely associated with coronary heart disease (CHD), whereas HDL with apoC-III is directly associated with CHD. We investigated how the presence of apoC-III affects the association between HDL and early stages of atherosclerosis measured as carotid intima-media thickness (cIMT).
We examined the cross-sectional associations between the apoA-I concentrations of HDL subspecies with and without apoC-III and cIMT measured by high resolution B-mode carotid ultrasonography among 847 participants from the European multi-center Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study.
HDL with and without apoC-III demonstrated significantly opposite associations with both cIMT indexes (p-heterogeneity of associations comparing the two subspecies was 0.002 for cIMT at common carotid artery (cIMT at CCA) and 0.006 for the maximum cIMT in any carotid segment (cIMT max)). Compared to the lowest quintile, the highest quintile of apoA-I in HDL without apoC-III was associated with 3.7% lower cIMT at CCA (p-trend = 0.01) or 7.3% lower cIMT max (p-trend = 0.003), while the highest quintile of apoA-I in HDL with apoC-III was associated with 4.4% higher cIMT at CCA (p-trend = 0.001) or 7.9% higher cIMT max (p-trend = 0.002). Total apoA-I as well as total HDL cholesterol was not associated with cIMT whereas higher levels of total apoC-III and apoC-III contained in HDL were significantly associated with higher cIMT (p-trend |
| doi_str_mv | 10.1016/j.atherosclerosis.2017.12.029 |
| format | Article |
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We examined the cross-sectional associations between the apoA-I concentrations of HDL subspecies with and without apoC-III and cIMT measured by high resolution B-mode carotid ultrasonography among 847 participants from the European multi-center Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study.
HDL with and without apoC-III demonstrated significantly opposite associations with both cIMT indexes (p-heterogeneity of associations comparing the two subspecies was 0.002 for cIMT at common carotid artery (cIMT at CCA) and 0.006 for the maximum cIMT in any carotid segment (cIMT max)). Compared to the lowest quintile, the highest quintile of apoA-I in HDL without apoC-III was associated with 3.7% lower cIMT at CCA (p-trend = 0.01) or 7.3% lower cIMT max (p-trend = 0.003), while the highest quintile of apoA-I in HDL with apoC-III was associated with 4.4% higher cIMT at CCA (p-trend = 0.001) or 7.9% higher cIMT max (p-trend = 0.002). Total apoA-I as well as total HDL cholesterol was not associated with cIMT whereas higher levels of total apoC-III and apoC-III contained in HDL were significantly associated with higher cIMT (p-trend<0.01).
HDL apoC-III is a promising target for atherosclerosis prevention and treatment.
•Two HDL subspecies had significantly opposite associations with cIMT.•HDL that contains apoC-III was directly associated with cIMT.•HDL that does not contain apoC-III was inversely associated with cIMT.•Neither HDL cholesterol nor apoA-I had a significant association with cIMT.•HDL apoC-III is a promising target for atherosclerosis prevention and treatment.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2017.12.029</identifier><identifier>PMID: 29351856</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Apolipoprotein A-I ; Apolipoprotein C-III ; Apolipoprotein C-III - blood ; Atherosclerosis ; Biomarkers - blood ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - epidemiology ; Carotid Intima-Media Thickness ; Carotid intima-media thickness (cIMT) ; Cross-Sectional Studies ; Europe - epidemiology ; Female ; HDL subspecies ; High density lipoprotein (HDL) ; Humans ; Lipoproteins, HDL - blood ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Risk Factors</subject><ispartof>Atherosclerosis, 2018-02, Vol.269, p.92-99</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-777a8e05f42bafe7579e00ff6436657acf970959e21fea7a85308ec3d7220ca43</citedby><cites>FETCH-LOGICAL-c389t-777a8e05f42bafe7579e00ff6436657acf970959e21fea7a85308ec3d7220ca43</cites><orcidid>0000-0002-8465-7717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S002191501731465X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29351856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Rain</creatorcontrib><creatorcontrib>Sacks, Frank M.</creatorcontrib><creatorcontrib>Hu, Frank B.</creatorcontrib><creatorcontrib>Rosner, Bernard</creatorcontrib><creatorcontrib>Furtado, Jeremy D.</creatorcontrib><creatorcontrib>Aroner, Sarah A.</creatorcontrib><creatorcontrib>Ferrannini, Ele</creatorcontrib><creatorcontrib>Baldi, Simona</creatorcontrib><creatorcontrib>Kozakova, Michaela</creatorcontrib><creatorcontrib>Balkau, Beverley</creatorcontrib><creatorcontrib>Natali, Andrea</creatorcontrib><creatorcontrib>Jensen, Majken K.</creatorcontrib><creatorcontrib>the RISC Investigators</creatorcontrib><creatorcontrib>RISC Investigators</creatorcontrib><title>High density lipoprotein with apolipoprotein C-III is associated with carotid intima-media thickness among generally healthy individuals</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>About 6–7% of high density lipoprotein (HDL) has a protein called apolipoprotein (apo) C-III that regulates lipoprotein metabolism and can provoke an inflammatory response. HDL without apoC-III is inversely associated with coronary heart disease (CHD), whereas HDL with apoC-III is directly associated with CHD. We investigated how the presence of apoC-III affects the association between HDL and early stages of atherosclerosis measured as carotid intima-media thickness (cIMT).
We examined the cross-sectional associations between the apoA-I concentrations of HDL subspecies with and without apoC-III and cIMT measured by high resolution B-mode carotid ultrasonography among 847 participants from the European multi-center Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study.
HDL with and without apoC-III demonstrated significantly opposite associations with both cIMT indexes (p-heterogeneity of associations comparing the two subspecies was 0.002 for cIMT at common carotid artery (cIMT at CCA) and 0.006 for the maximum cIMT in any carotid segment (cIMT max)). Compared to the lowest quintile, the highest quintile of apoA-I in HDL without apoC-III was associated with 3.7% lower cIMT at CCA (p-trend = 0.01) or 7.3% lower cIMT max (p-trend = 0.003), while the highest quintile of apoA-I in HDL with apoC-III was associated with 4.4% higher cIMT at CCA (p-trend = 0.001) or 7.9% higher cIMT max (p-trend = 0.002). Total apoA-I as well as total HDL cholesterol was not associated with cIMT whereas higher levels of total apoC-III and apoC-III contained in HDL were significantly associated with higher cIMT (p-trend<0.01).
HDL apoC-III is a promising target for atherosclerosis prevention and treatment.
•Two HDL subspecies had significantly opposite associations with cIMT.•HDL that contains apoC-III was directly associated with cIMT.•HDL that does not contain apoC-III was inversely associated with cIMT.•Neither HDL cholesterol nor apoA-I had a significant association with cIMT.•HDL apoC-III is a promising target for atherosclerosis prevention and treatment.</description><subject>Adult</subject><subject>Apolipoprotein A-I</subject><subject>Apolipoprotein C-III</subject><subject>Apolipoprotein C-III - blood</subject><subject>Atherosclerosis</subject><subject>Biomarkers - blood</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Carotid intima-media thickness (cIMT)</subject><subject>Cross-Sectional Studies</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>HDL subspecies</subject><subject>High density lipoprotein (HDL)</subject><subject>Humans</subject><subject>Lipoproteins, HDL - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu2zAQRImiRe24_YWAlwK9SFlSoigeciiMJjEQoJf2TDDUylpXllyRTuE_yGeHhpMgyCkXLkC82cXMMPZNQC5AVBeb3MUOpzH4_vhSyCUInQuZgzQf2FzU2mSirMuPbA4gRWaEghk7C2EDAKUW9Wc2k6ZQolbVnD3c0LrjDQ6B4oH3tBt30xiRBv6fYsfdbnz9t8xWqxWnwF0IoycXsTlx3iWCGk5DpK3LttiQ47Ej_3fAkPDtOKz5GgecXN8feIeuj90h4Q3dU7N3ffjCPrVp4NenuWB_rn7-Xt5kt7-uV8sft5kvahMzrbWrEVRbyjvXolbaIEDbVmVRVUo73xoNRhmUokWXWFVAjb5otJTgXVks2PfT3uTp3x5DtFsKHvveDTjugxWmTnIlKkjo5Qn1KegwYWt3U3I3HawAeyzDbuybMuyxDCukTWUk_fnTqf1dSuRF_Zx-Aq5PACbD94STDZ5w8Cm9CX20zUjvPPUITFqotQ</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Yamamoto, Rain</creator><creator>Sacks, Frank M.</creator><creator>Hu, Frank B.</creator><creator>Rosner, Bernard</creator><creator>Furtado, Jeremy D.</creator><creator>Aroner, Sarah A.</creator><creator>Ferrannini, Ele</creator><creator>Baldi, Simona</creator><creator>Kozakova, Michaela</creator><creator>Balkau, Beverley</creator><creator>Natali, Andrea</creator><creator>Jensen, Majken K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8465-7717</orcidid></search><sort><creationdate>201802</creationdate><title>High density lipoprotein with apolipoprotein C-III is associated with carotid intima-media thickness among generally healthy individuals</title><author>Yamamoto, Rain ; Sacks, Frank M. ; Hu, Frank B. ; Rosner, Bernard ; Furtado, Jeremy D. ; Aroner, Sarah A. ; Ferrannini, Ele ; Baldi, Simona ; Kozakova, Michaela ; Balkau, Beverley ; Natali, Andrea ; Jensen, Majken K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-777a8e05f42bafe7579e00ff6436657acf970959e21fea7a85308ec3d7220ca43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Apolipoprotein A-I</topic><topic>Apolipoprotein C-III</topic><topic>Apolipoprotein C-III - blood</topic><topic>Atherosclerosis</topic><topic>Biomarkers - blood</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Carotid intima-media thickness (cIMT)</topic><topic>Cross-Sectional Studies</topic><topic>Europe - epidemiology</topic><topic>Female</topic><topic>HDL subspecies</topic><topic>High density lipoprotein (HDL)</topic><topic>Humans</topic><topic>Lipoproteins, HDL - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Rain</creatorcontrib><creatorcontrib>Sacks, Frank M.</creatorcontrib><creatorcontrib>Hu, Frank B.</creatorcontrib><creatorcontrib>Rosner, Bernard</creatorcontrib><creatorcontrib>Furtado, Jeremy D.</creatorcontrib><creatorcontrib>Aroner, Sarah A.</creatorcontrib><creatorcontrib>Ferrannini, Ele</creatorcontrib><creatorcontrib>Baldi, Simona</creatorcontrib><creatorcontrib>Kozakova, Michaela</creatorcontrib><creatorcontrib>Balkau, Beverley</creatorcontrib><creatorcontrib>Natali, Andrea</creatorcontrib><creatorcontrib>Jensen, Majken K.</creatorcontrib><creatorcontrib>the RISC Investigators</creatorcontrib><creatorcontrib>RISC Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Rain</au><au>Sacks, Frank M.</au><au>Hu, Frank B.</au><au>Rosner, Bernard</au><au>Furtado, Jeremy D.</au><au>Aroner, Sarah A.</au><au>Ferrannini, Ele</au><au>Baldi, Simona</au><au>Kozakova, Michaela</au><au>Balkau, Beverley</au><au>Natali, Andrea</au><au>Jensen, Majken K.</au><aucorp>the RISC Investigators</aucorp><aucorp>RISC Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High density lipoprotein with apolipoprotein C-III is associated with carotid intima-media thickness among generally healthy individuals</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2018-02</date><risdate>2018</risdate><volume>269</volume><spage>92</spage><epage>99</epage><pages>92-99</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>About 6–7% of high density lipoprotein (HDL) has a protein called apolipoprotein (apo) C-III that regulates lipoprotein metabolism and can provoke an inflammatory response. HDL without apoC-III is inversely associated with coronary heart disease (CHD), whereas HDL with apoC-III is directly associated with CHD. We investigated how the presence of apoC-III affects the association between HDL and early stages of atherosclerosis measured as carotid intima-media thickness (cIMT).
We examined the cross-sectional associations between the apoA-I concentrations of HDL subspecies with and without apoC-III and cIMT measured by high resolution B-mode carotid ultrasonography among 847 participants from the European multi-center Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study.
HDL with and without apoC-III demonstrated significantly opposite associations with both cIMT indexes (p-heterogeneity of associations comparing the two subspecies was 0.002 for cIMT at common carotid artery (cIMT at CCA) and 0.006 for the maximum cIMT in any carotid segment (cIMT max)). Compared to the lowest quintile, the highest quintile of apoA-I in HDL without apoC-III was associated with 3.7% lower cIMT at CCA (p-trend = 0.01) or 7.3% lower cIMT max (p-trend = 0.003), while the highest quintile of apoA-I in HDL with apoC-III was associated with 4.4% higher cIMT at CCA (p-trend = 0.001) or 7.9% higher cIMT max (p-trend = 0.002). Total apoA-I as well as total HDL cholesterol was not associated with cIMT whereas higher levels of total apoC-III and apoC-III contained in HDL were significantly associated with higher cIMT (p-trend<0.01).
HDL apoC-III is a promising target for atherosclerosis prevention and treatment.
•Two HDL subspecies had significantly opposite associations with cIMT.•HDL that contains apoC-III was directly associated with cIMT.•HDL that does not contain apoC-III was inversely associated with cIMT.•Neither HDL cholesterol nor apoA-I had a significant association with cIMT.•HDL apoC-III is a promising target for atherosclerosis prevention and treatment.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29351856</pmid><doi>10.1016/j.atherosclerosis.2017.12.029</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8465-7717</orcidid></addata></record> |
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| ispartof | Atherosclerosis, 2018-02, Vol.269, p.92-99 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Apolipoprotein A-I Apolipoprotein C-III Apolipoprotein C-III - blood Atherosclerosis Biomarkers - blood Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Carotid Intima-Media Thickness Carotid intima-media thickness (cIMT) Cross-Sectional Studies Europe - epidemiology Female HDL subspecies High density lipoprotein (HDL) Humans Lipoproteins, HDL - blood Male Middle Aged Predictive Value of Tests Prospective Studies Risk Factors |
| title | High density lipoprotein with apolipoprotein C-III is associated with carotid intima-media thickness among generally healthy individuals |
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