Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions

Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions

Complexation of ca. 1000 ppm Pd­(OAc)2 with the ligand HandaPhos (1–1.5:1) leads to a precatalyst that efficiently mediates Sonogashira couplings in aqueous nanomicelles under very mild conditions. Neither copper nor organic solvent is required in the reaction medium, and the product can be isolated...

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Veröffentlicht in:Organic letters 2018-02, Vol.20 (3), p.542-545
Hauptverfasser: Handa, Sachin, Smith, Justin D, Zhang, Yitao, Takale, Balaram S, Gallou, Fabrice, Lipshutz, Bruce H
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container_end_page 545
container_issue 3
container_start_page 542
container_title Organic letters
container_volume 20
creator Handa, Sachin
Smith, Justin D
Zhang, Yitao
Takale, Balaram S
Gallou, Fabrice
Lipshutz, Bruce H
description Complexation of ca. 1000 ppm Pd­(OAc)2 with the ligand HandaPhos (1–1.5:1) leads to a precatalyst that efficiently mediates Sonogashira couplings in aqueous nanomicelles under very mild conditions. Neither copper nor organic solvent is required in the reaction medium, and the product can be isolated directly from the reaction flask, leaving behind a reaction mixture that can be recycled without additional additives.
doi_str_mv 10.1021/acs.orglett.7b03621
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title Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions
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