Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy
Purpose The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopa...
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| Veröffentlicht in: | Abdominal imaging 2018-09, Vol.43 (9), p.2221-2230 |
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| creator | Delli Pizzi, Andrea Cianci, Roberta Genovesi, Domenico Esposito, Gianluigi Timpani, Mauro Tavoletta, Alessandra Pulsone, Pierluigi Basilico, Raffaella Gabrielli, Daniela Rosa, Consuelo Caravatta, Luciana Di Tommaso, Monica Caulo, Massimo Filippone, Antonella |
| description | Purpose
The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopathologic response.
Methods
Forty-three patients receiving CRT for LARC and 3.0T magnetic resonance imaging with diffusion-weighted sequences before treatment, 2 weeks during, and 8 weeks post the completion of CRT were included. ADC values were calculated at each time point and percentage of ADC changes at 2 weeks (ΔADC during) and 8 weeks (ΔADC post) were assessed. Data were correlated to surgical results and histopathologic tumor regression grade (TRG), according to Mandard’s classification. ADC values and ΔADCs of complete responders (CR; TRG1) and non-complete responders (non-CR; TRG 2-5) were compared. Receiver-operating characteristic curve (ROC) analysis was used to assess diagnostic accuracy of ΔADC for differentiating CR from non-CR. The correlation with TRG was investigated using Spearman's rank test.
Results
ΔADC during and ΔADC post were significantly higher in CR (33.9% and 57%, respectively) compared to non-CR (13.5% and 2.2%, respectively) group (
p
= 0.006 and
p
|
| doi_str_mv | 10.1007/s00261-018-1457-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1989592830</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1992795503</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-4c1643c7f8d91deb2a8309ce7ea6bd31f4c773e7c7663181e854716f5a4bf5983</originalsourceid><addsrcrecordid>eNp1kc9qFTEUxoMottQ-gBsJuHEzNX8mk8xSilqhYBctdBdyMyf3pswkY5JpuS_ns5nprUWErpKT73e-c8iH0HtKzigh8nMmhHW0IVQ1tBWyUa_QMeNd1xAi1Ovne3t7hE5zviOE0E5QysRbdMR6zhlr1TH6fQXJxTSZYAFHhwfv3JJ9DM0D-O2uwIAnsw1QvMUJcgyPoK9vPmyxKZifkWtcHTCYNO6xyRlyniCU1a0sU1Vq3xxDrm0Bj9GaceWG-9VpqKItZsR2rRIuCcw688GXHZ4TxBmSKf4esN1B9TKDr2UMuOyqMO_foTfOjBlOn84TdPPt6_X5RXP58_uP8y-XjeWSlaa1tGu5lU4NPR1gw4zipLcgwXSbgVPXWik5SCu7jlNFQYlW0s4J026c6BU_QZ8OvnOKvxbIRU8-WxhHEyAuWdNe9aJn1bWiH_9D7-KSQt2uUj2TvRCEV4oeKJtizgmcnlP91bTXlOg1X33IV9d89ZqvXpf48OS8bCYYnjv-plkBdgBylcIW0j-jX3T9AxqvtEM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1992795503</pqid></control><display><type>article</type><title>Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy</title><source>SpringerLink Journals</source><creator>Delli Pizzi, Andrea ; Cianci, Roberta ; Genovesi, Domenico ; Esposito, Gianluigi ; Timpani, Mauro ; Tavoletta, Alessandra ; Pulsone, Pierluigi ; Basilico, Raffaella ; Gabrielli, Daniela ; Rosa, Consuelo ; Caravatta, Luciana ; Di Tommaso, Monica ; Caulo, Massimo ; Filippone, Antonella</creator><creatorcontrib>Delli Pizzi, Andrea ; Cianci, Roberta ; Genovesi, Domenico ; Esposito, Gianluigi ; Timpani, Mauro ; Tavoletta, Alessandra ; Pulsone, Pierluigi ; Basilico, Raffaella ; Gabrielli, Daniela ; Rosa, Consuelo ; Caravatta, Luciana ; Di Tommaso, Monica ; Caulo, Massimo ; Filippone, Antonella</creatorcontrib><description>Purpose
The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopathologic response.
Methods
Forty-three patients receiving CRT for LARC and 3.0T magnetic resonance imaging with diffusion-weighted sequences before treatment, 2 weeks during, and 8 weeks post the completion of CRT were included. ADC values were calculated at each time point and percentage of ADC changes at 2 weeks (ΔADC during) and 8 weeks (ΔADC post) were assessed. Data were correlated to surgical results and histopathologic tumor regression grade (TRG), according to Mandard’s classification. ADC values and ΔADCs of complete responders (CR; TRG1) and non-complete responders (non-CR; TRG 2-5) were compared. Receiver-operating characteristic curve (ROC) analysis was used to assess diagnostic accuracy of ΔADC for differentiating CR from non-CR. The correlation with TRG was investigated using Spearman's rank test.
Results
ΔADC during and ΔADC post were significantly higher in CR (33.9% and 57%, respectively) compared to non-CR (13.5% and 2.2%, respectively) group (
p
= 0.006 and
p
< 0.001, respectively). ROC analysis revealed the following diagnostic performances: ΔADC during: AUC 0.78 (0.08),
p
= 0.004, cut-off 20.6% (sensitivity 75% and specificity 76.5%); ΔADC post: AUC 0.94 (0.04),
p
≤ 0.001, cut-off 22% (sensitivity 95% and specificity 82.4%). Significant moderate and good negative correlation was found between ΔADC during and ΔADC post and TRG (
r
= − 0.418,
p
= 0.007;
r
= − 694,
p
≤ 0.001, respectively).
Conclusion
ΔADC at 2 weeks after the beginning of CRT is a reliable tool to early assess treatment response.</description><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-018-1457-8</identifier><identifier>PMID: 29332248</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer ; Chemoradiotherapy ; Chemotherapy ; Colorectal cancer ; Correlation ; Diagnostic systems ; Diffusion ; Diffusion coefficient ; Gastroenterology ; Hepatology ; Imaging ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; NMR ; Nuclear magnetic resonance ; Quality ; Radiation therapy ; Radiology ; Rectum ; Regression analysis ; Resonance ; Sensitivity ; Surgery ; Surgical instruments ; Therapy</subject><ispartof>Abdominal imaging, 2018-09, Vol.43 (9), p.2221-2230</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Abdominal Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4c1643c7f8d91deb2a8309ce7ea6bd31f4c773e7c7663181e854716f5a4bf5983</citedby><cites>FETCH-LOGICAL-c372t-4c1643c7f8d91deb2a8309ce7ea6bd31f4c773e7c7663181e854716f5a4bf5983</cites><orcidid>0000-0002-2011-3753</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00261-018-1457-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00261-018-1457-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29332248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delli Pizzi, Andrea</creatorcontrib><creatorcontrib>Cianci, Roberta</creatorcontrib><creatorcontrib>Genovesi, Domenico</creatorcontrib><creatorcontrib>Esposito, Gianluigi</creatorcontrib><creatorcontrib>Timpani, Mauro</creatorcontrib><creatorcontrib>Tavoletta, Alessandra</creatorcontrib><creatorcontrib>Pulsone, Pierluigi</creatorcontrib><creatorcontrib>Basilico, Raffaella</creatorcontrib><creatorcontrib>Gabrielli, Daniela</creatorcontrib><creatorcontrib>Rosa, Consuelo</creatorcontrib><creatorcontrib>Caravatta, Luciana</creatorcontrib><creatorcontrib>Di Tommaso, Monica</creatorcontrib><creatorcontrib>Caulo, Massimo</creatorcontrib><creatorcontrib>Filippone, Antonella</creatorcontrib><title>Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Purpose
The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopathologic response.
Methods
Forty-three patients receiving CRT for LARC and 3.0T magnetic resonance imaging with diffusion-weighted sequences before treatment, 2 weeks during, and 8 weeks post the completion of CRT were included. ADC values were calculated at each time point and percentage of ADC changes at 2 weeks (ΔADC during) and 8 weeks (ΔADC post) were assessed. Data were correlated to surgical results and histopathologic tumor regression grade (TRG), according to Mandard’s classification. ADC values and ΔADCs of complete responders (CR; TRG1) and non-complete responders (non-CR; TRG 2-5) were compared. Receiver-operating characteristic curve (ROC) analysis was used to assess diagnostic accuracy of ΔADC for differentiating CR from non-CR. The correlation with TRG was investigated using Spearman's rank test.
Results
ΔADC during and ΔADC post were significantly higher in CR (33.9% and 57%, respectively) compared to non-CR (13.5% and 2.2%, respectively) group (
p
= 0.006 and
p
< 0.001, respectively). ROC analysis revealed the following diagnostic performances: ΔADC during: AUC 0.78 (0.08),
p
= 0.004, cut-off 20.6% (sensitivity 75% and specificity 76.5%); ΔADC post: AUC 0.94 (0.04),
p
≤ 0.001, cut-off 22% (sensitivity 95% and specificity 82.4%). Significant moderate and good negative correlation was found between ΔADC during and ΔADC post and TRG (
r
= − 0.418,
p
= 0.007;
r
= − 694,
p
≤ 0.001, respectively).
Conclusion
ΔADC at 2 weeks after the beginning of CRT is a reliable tool to early assess treatment response.</description><subject>Cancer</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Correlation</subject><subject>Diagnostic systems</subject><subject>Diffusion</subject><subject>Diffusion coefficient</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Imaging</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Quality</subject><subject>Radiation therapy</subject><subject>Radiology</subject><subject>Rectum</subject><subject>Regression analysis</subject><subject>Resonance</subject><subject>Sensitivity</subject><subject>Surgery</subject><subject>Surgical instruments</subject><subject>Therapy</subject><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kc9qFTEUxoMottQ-gBsJuHEzNX8mk8xSilqhYBctdBdyMyf3pswkY5JpuS_ns5nprUWErpKT73e-c8iH0HtKzigh8nMmhHW0IVQ1tBWyUa_QMeNd1xAi1Ovne3t7hE5zviOE0E5QysRbdMR6zhlr1TH6fQXJxTSZYAFHhwfv3JJ9DM0D-O2uwIAnsw1QvMUJcgyPoK9vPmyxKZifkWtcHTCYNO6xyRlyniCU1a0sU1Vq3xxDrm0Bj9GaceWG-9VpqKItZsR2rRIuCcw688GXHZ4TxBmSKf4esN1B9TKDr2UMuOyqMO_foTfOjBlOn84TdPPt6_X5RXP58_uP8y-XjeWSlaa1tGu5lU4NPR1gw4zipLcgwXSbgVPXWik5SCu7jlNFQYlW0s4J026c6BU_QZ8OvnOKvxbIRU8-WxhHEyAuWdNe9aJn1bWiH_9D7-KSQt2uUj2TvRCEV4oeKJtizgmcnlP91bTXlOg1X33IV9d89ZqvXpf48OS8bCYYnjv-plkBdgBylcIW0j-jX3T9AxqvtEM</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Delli Pizzi, Andrea</creator><creator>Cianci, Roberta</creator><creator>Genovesi, Domenico</creator><creator>Esposito, Gianluigi</creator><creator>Timpani, Mauro</creator><creator>Tavoletta, Alessandra</creator><creator>Pulsone, Pierluigi</creator><creator>Basilico, Raffaella</creator><creator>Gabrielli, Daniela</creator><creator>Rosa, Consuelo</creator><creator>Caravatta, Luciana</creator><creator>Di Tommaso, Monica</creator><creator>Caulo, Massimo</creator><creator>Filippone, Antonella</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2011-3753</orcidid></search><sort><creationdate>20180901</creationdate><title>Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy</title><author>Delli Pizzi, Andrea ; Cianci, Roberta ; Genovesi, Domenico ; Esposito, Gianluigi ; Timpani, Mauro ; Tavoletta, Alessandra ; Pulsone, Pierluigi ; Basilico, Raffaella ; Gabrielli, Daniela ; Rosa, Consuelo ; Caravatta, Luciana ; Di Tommaso, Monica ; Caulo, Massimo ; Filippone, Antonella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4c1643c7f8d91deb2a8309ce7ea6bd31f4c773e7c7663181e854716f5a4bf5983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer</topic><topic>Chemoradiotherapy</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Correlation</topic><topic>Diagnostic systems</topic><topic>Diffusion</topic><topic>Diffusion coefficient</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Imaging</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Quality</topic><topic>Radiation therapy</topic><topic>Radiology</topic><topic>Rectum</topic><topic>Regression analysis</topic><topic>Resonance</topic><topic>Sensitivity</topic><topic>Surgery</topic><topic>Surgical instruments</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delli Pizzi, Andrea</creatorcontrib><creatorcontrib>Cianci, Roberta</creatorcontrib><creatorcontrib>Genovesi, Domenico</creatorcontrib><creatorcontrib>Esposito, Gianluigi</creatorcontrib><creatorcontrib>Timpani, Mauro</creatorcontrib><creatorcontrib>Tavoletta, Alessandra</creatorcontrib><creatorcontrib>Pulsone, Pierluigi</creatorcontrib><creatorcontrib>Basilico, Raffaella</creatorcontrib><creatorcontrib>Gabrielli, Daniela</creatorcontrib><creatorcontrib>Rosa, Consuelo</creatorcontrib><creatorcontrib>Caravatta, Luciana</creatorcontrib><creatorcontrib>Di Tommaso, Monica</creatorcontrib><creatorcontrib>Caulo, Massimo</creatorcontrib><creatorcontrib>Filippone, Antonella</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Abdominal imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delli Pizzi, Andrea</au><au>Cianci, Roberta</au><au>Genovesi, Domenico</au><au>Esposito, Gianluigi</au><au>Timpani, Mauro</au><au>Tavoletta, Alessandra</au><au>Pulsone, Pierluigi</au><au>Basilico, Raffaella</au><au>Gabrielli, Daniela</au><au>Rosa, Consuelo</au><au>Caravatta, Luciana</au><au>Di Tommaso, Monica</au><au>Caulo, Massimo</au><au>Filippone, Antonella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy</atitle><jtitle>Abdominal imaging</jtitle><stitle>Abdom Radiol</stitle><addtitle>Abdom Radiol (NY)</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>43</volume><issue>9</issue><spage>2221</spage><epage>2230</epage><pages>2221-2230</pages><issn>2366-004X</issn><eissn>2366-0058</eissn><abstract>Purpose
The purpose of the article is to determine whether changes in apparent diffusion coefficient (ADC) values of locally advanced rectal cancer (LARC) obtained 2 weeks after the beginning of chemoradiation therapy (CRT) allow to predict treatment response and whether correlate with tumor histopathologic response.
Methods
Forty-three patients receiving CRT for LARC and 3.0T magnetic resonance imaging with diffusion-weighted sequences before treatment, 2 weeks during, and 8 weeks post the completion of CRT were included. ADC values were calculated at each time point and percentage of ADC changes at 2 weeks (ΔADC during) and 8 weeks (ΔADC post) were assessed. Data were correlated to surgical results and histopathologic tumor regression grade (TRG), according to Mandard’s classification. ADC values and ΔADCs of complete responders (CR; TRG1) and non-complete responders (non-CR; TRG 2-5) were compared. Receiver-operating characteristic curve (ROC) analysis was used to assess diagnostic accuracy of ΔADC for differentiating CR from non-CR. The correlation with TRG was investigated using Spearman's rank test.
Results
ΔADC during and ΔADC post were significantly higher in CR (33.9% and 57%, respectively) compared to non-CR (13.5% and 2.2%, respectively) group (
p
= 0.006 and
p
< 0.001, respectively). ROC analysis revealed the following diagnostic performances: ΔADC during: AUC 0.78 (0.08),
p
= 0.004, cut-off 20.6% (sensitivity 75% and specificity 76.5%); ΔADC post: AUC 0.94 (0.04),
p
≤ 0.001, cut-off 22% (sensitivity 95% and specificity 82.4%). Significant moderate and good negative correlation was found between ΔADC during and ΔADC post and TRG (
r
= − 0.418,
p
= 0.007;
r
= − 694,
p
≤ 0.001, respectively).
Conclusion
ΔADC at 2 weeks after the beginning of CRT is a reliable tool to early assess treatment response.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29332248</pmid><doi>10.1007/s00261-018-1457-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2011-3753</orcidid></addata></record> |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_1989592830 |
| source | SpringerLink Journals |
| subjects | Cancer Chemoradiotherapy Chemotherapy Colorectal cancer Correlation Diagnostic systems Diffusion Diffusion coefficient Gastroenterology Hepatology Imaging Magnetic resonance imaging Medicine Medicine & Public Health NMR Nuclear magnetic resonance Quality Radiation therapy Radiology Rectum Regression analysis Resonance Sensitivity Surgery Surgical instruments Therapy |
| title | Performance of diffusion-weighted magnetic resonance imaging at 3.0T for early assessment of tumor response in locally advanced rectal cancer treated with preoperative chemoradiation therapy |
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